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Injection used for treating chronic congestive cardiac failure, and preparation method thereof

A technology for heart failure and injections, which can be used in pharmaceutical formulations, cardiovascular diseases, and medical raw materials derived from arthropods. The effect of reducing pulmonary artery pressure and increasing coronary flow

Active Publication Date: 2012-01-18
YUNNAN TENGCHONG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern scientific research shows that cockroach extract has strong biological activity, but there are still great limitations in the application of cockroach extract in the existing technology, and the application potential of cockroach extract needs to be further developed and utilized

Method used

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  • Injection used for treating chronic congestive cardiac failure, and preparation method thereof
  • Injection used for treating chronic congestive cardiac failure, and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0023] The preparation method of the injection of the present invention comprises:

[0024] Preparation of cockroach alcohol extract: crush dry cockroach body into coarse powder, extract by 5-10 times the weight of 90-95% ethanol percolation for 8-12 hours, and concentrate the extract under reduced pressure to obtain a thick paste; add 4 ~6 times of purified water is fully stirred and allowed to stand for 12 to 24 hours to separate oil and water, remove sediment and grease, collect the liquid in the water layer, add medicinal activated carbon and let it stand for 1 to 2 hours to absorb the liquid until colorless, then pack it into a column, Elute with water-saturated n-butanol, add 8-10 times the weight of 65-85% ethanol to the eluate after concentration under reduced pressure for secondary alcohol extraction, refrigerate for 12-24 hours and filter, and the filtrate is concentrated under reduced pressure, then Add 8 to 10 times the weight of purified water for water extraction...

Embodiment approach

[0027] In the preparation of the cockroach extract, add 5-10 times the weight ratio of 90-95% ethanol to impregnate the cockroach coarse powder for 48-60 hours, then use 90-95% ethanol as a solvent to slowly percolate until the filtrate is slightly yellow , and the filtrate was concentrated under reduced pressure to obtain a thick paste.

[0028] The temperature during centrifugation during the preparation of the cockroach extract is 2-6°C.

[0029] The refrigerated temperature in the preparation of the cockroach extract is 4-8°C.

[0030] In the preparation of the cockroach extract, the temperature for concentrating under reduced pressure is 60-80°C.

[0031] In the preparation of the cockroach extract, the relative density of the thick paste is 1.2-1.3.

Embodiment 1

[0033] Take 1000g of dried cockroach body and crush it into coarse powder, add 5 times the weight of 90% ethanol to impregnate for 48 hours, then extract by percolating with 90% ethanol for 8 hours, and concentrate the extract under reduced pressure at 60°C to obtain a relative density of 1.2 ~1.3 thick ointment; add 4 times of purified water, fully stir and let stand for 12 hours to separate oil and water, remove sediment and grease, collect water layer liquid, add medicinal activated carbon and stand for 1 hour to absorb liquid until colorless, Pack the column, elute with water-saturated n-butanol, add 8 times the weight of 65% ethanol to the eluate after concentration under reduced pressure for secondary alcohol extraction, refrigerate at 4°C for 12 hours and filter, and depressurize the filtrate at 60°C After concentration, add 8 times the weight of purified water for water extraction, refrigerate at 4°C for 12 hours, then centrifuge and filter at 2°C to obtain the water ex...

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PUM

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Abstract

The invention discloses an injection used for treating chronic congestive cardiac failure, and a preparation method thereof. The medicine composition comprises components of, by weight: 3% to 6% of cockroach extract, 10% to 30% of polyethylene glycol, 0.7% to 1.0% of sodium chloride, and balance of water for injection. The preparation method comprises steps that: first, the cockroach extract is prepared through steps that: dried cockroach polypides are crushed into powder, the powder is processed from ethanol refluxing, and the extract is concentrated with reduced pressure, such that a thick paste is obtained; purified water is added to the paste for carrying out an oil-water separation process; medicine in the water layer is collected, and is processed through active carbon absorption, packing, and n-butyl alcohol elution; the eluant is concentrated with reduced pressure, and is processed through a secondary ethanol extraction; the obtained filtrate is concentrated with reduced pressure, and is processed through water extraction, centrifugation, filtration, decoloration, ultrafiltration, and concentration with reduced pressure, such that the cockroach extract thick paste is obtained; then, the medicine injection is prepared through steps that: the cockroach extract, medicinal polyethylene glycol and medicinal sodium chloride are mixed according to the formulation; the pH value is regulated to 5.4-6.4; the mixture is diluted to 1000ml by using the water for injection; the obtained solution is filtered, encapsulated, sterilized, lamp inspected, and packaged, such that cockroach extract injections are obtained.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, in particular to an injection for treating chronic congestive heart failure and a preparation method thereof. Background technique [0002] The cockroach, also known as the American cockroach (commonly known as the cockroach), is the largest in the family Blatella, with an adult body length of 29 to 35 mm. The epidermis of the cockroach contains sclera and chitin, elements such as bromine, zinc, nickel, manganese, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, and magnesium. Thirteen kinds of amino acids can be obtained by hydrolysis of the muscles, and there are also micronutrients stored in the body. Vitamins B1, B2, niacin and ascorbic acid, etc. Lymph contains trehalose, trehalase, glycoprotein, inositol, protocatechuic acid glucoside, etc.; the whole body contains ergothioneine, lobster creatine, trigonelline , glycine, betaine, analline, trimethylamine, adeni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/08A61P9/04
Inventor 李筱玲邵维在李立华杨枝时徐自学
Owner YUNNAN TENGCHONG PHARMA FACTORY
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