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Antithrombogenic hollow fiber membranes and filters

A fiber membrane and filter technology, applied in blood filtration, membrane technology, suction devices, etc., can solve problems such as contraindications to patients

Active Publication Date: 2012-01-11
INTERFACE BIOLOGICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although beneficial, the use of heparin can be complicated by allergic reactions and bleeding in some patients and may be contraindicated in patients treated with some medications

Method used

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  • Antithrombogenic hollow fiber membranes and filters
  • Antithrombogenic hollow fiber membranes and filters
  • Antithrombogenic hollow fiber membranes and filters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0217] Example 1. Diagram and calculation of packing area

[0218] Figure 20A is a scanning electron micrograph of a single hollow fiber. Figure 20A B is a schematic representation of a hollow fiber bundle. Figures 20A-20B and the calculations below highlight the ability of fiber bundles to provide surface area to resist coagulation when in contact with blood.

[0219] The calculations below are based on Figure 20B, which is a conceptual drawing of a commercially available CRRT blood filter composed of 5,000 fiber bundles with the following dimensions:

[0220] a) Diameter of encapsulation area + fiber area = 3.5 cm

[0221] b) The fiber has an outer diameter (OD) = 290 μm and an inner diameter (ID) = 200 μm

[0222] c) Total package and fiber area = πr 2 =3.142(3.5 / 2) 2 cm 2 =9.623cm 2

[0223] d) Area of ​​the hollow part = π(ID / 2) 2 =3.142 / 4×(0.020) 2 cm 2 =3.142×10 -4 cm 2

[0224] e) The area of ​​the hollow portion for 5,000 fibers = 5,000×3.142×10 -...

Embodiment 2

[0231] Example 2. Surface-modified macromolecules in thin films of PS / PVP polymer blends

[0232] Membranes were prepared to demonstrate that the hollow fiber membranes of the present invention may consist of surfaces in the mixture from which they are prepared. Surface-modified macromolecules (SMM, 5 wt%), polysulfone (PS, 10 wt%), and polyvinylpyrrolidone (PVP, 5 wt%) were dissolved in a mixture of dimethylacetamide and tetrahydrofuran (about 80 wt%). Films with a thickness of 254 μm were cast on Teflon substrates and subsequently dried and analyzed for surface fluorine and nitrogen content. Results are provided in Table 2 for the four solution-cast formulated films analyzed, each utilizing a different surface-modifying macromolecule.

[0233] Table 2

[0234]

[0235] For the four films, the surface fluorine content is provided by X-ray photoelectron spectroscopy (XPS) results, and the elemental analysis (EA) of the bulk (neat) SMM is provided for comparison. The diff...

Embodiment 3

[0236] Example 3. Surface-modified macromolecules in fibers of PS / PVP polymer blends

[0237] The fibers were also analyzed for fluorine and nitrogen content. The results are provided in Table 3 for the four solution spun fibers analyzed, each utilizing a different surface modifying macromolecule (VII-a, VIII-a, IX-a, and XI-a).

[0238] table 3

[0239]

[0240] X-ray photoelectron spectroscopy (XPS) data indicated that all SMM-modified fibers had varying degrees of surface fluorine in the inner (IS) and outer (OS) surfaces that actually come into contact with blood during hemodialysis.

[0241] Table 3 also provides the elemental analysis (EA) and %F of the SMM in the bulk, which indicates the amount of additive incorporated into the fiber compared to the amount targeted for incorporation. For VII-a, the EA of %F indicated that 6 wt% of the additive was incorporated, only 4 wt% was actually present. This loss of approximately 33% can be attributed to the harsh conditio...

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Abstract

The invention relates to extracorporeal blood circuits, and components thereof (e. g. , hollow fiber membranes, potted bundles, and blood tubing), including 0. 005% to 10% (w / w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.

Description

technical field [0001] The present invention relates to an anticoagulant extracorporeal blood circuit (circuit, circuit) and components (parts) thereof, such as hollow fiber membranes, blood tubing (blood tubing), and filters, and their applications in hemofiltration, hemodialysis, hemodialysis Applications in filtration, blood concentration, blood oxygenation, and related uses. Background technique [0002] In order to treat patients suffering from renal failure, various blood purification methods have been proposed in which blood is taken from a patient's living body to be purified, and then the purified blood is returned to the body. For example, blood purification methods using extracorporeal circulation are classified into the following types: hemodialysis (HD) by diffusion, hemofiltration (HF) in which body fluid removal / replacement is performed by ultrafiltration, and hemodiafiltration in which HD and HF are combined ( HDF). [0003] The methods mentioned above are ...

Claims

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Application Information

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IPC IPC(8): B01D71/06B01D67/00B01D69/08B01D69/02B01D63/02B01D61/00A61M1/18A61M1/34A61M1/00
Inventor 桑乔伊·穆利克张纬伦陈汉杰马克·斯蒂德曼露西塔·埃斯范德
Owner INTERFACE BIOLOGICS INC
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