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Preparation method and application of traditional Chinese medicinal immunoglobulin compound preparation

A technology of immunoglobulin and egg yolk immunoglobulin, which is applied in application, drug combination, antibacterial drugs, etc., can solve the problems of short duration of maternal immunoglobulin, poor control effect, drug resistance, etc., and achieve inhibition The growth of intestinal pathogenic bacteria, mild conditions, enhance the antibacterial effect of the body

Inactive Publication Date: 2012-01-04
方希修
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, antibiotics can lead to drug residues and drug resistance in animals; immunizing sows with vaccines can increase the content of immunoglobulins in breast milk, but the duration of maternal immunoglobulins is short, which is not enough to protect piglets from disease; oral administration of hyperimmune animal serum can effectively prevent and treat the disease, but the cost is high and it is difficult to popularize and apply it in production
[0006] Antibiotics are widely used in production as an effective drug to control bacterial infections, but the problem of drug resistance caused by long-term use of antibiotics and the phenomenon of excessive use of antibiotics in production are becoming more and more prominent, but the control effect is not optimistic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Raw materials: Chinese herbal medicine extract, egg yolk immunoglobulin, carrier

[0023] 1.1 Preparation of Chinese herbal medicine extract:

[0024] According to the weight ratio of Chinese herbal medicines such as pulsatilla, honeysuckle, purslane, flavescens, plantain, purslane, houttuynia cordata, licorice and other Chinese herbal medicines in a weight ratio of 1:1:1:1:1:1:1:1:1, use fine grinding After pulverized by a machine and mixed, the active ingredients are extracted by ultrasonic waves. The soaking time before extraction is 60-90 minutes. The ultrasonic frequency is 20-40kHz, and the ultrasonic treatment is 30min. After filtration, it is made into powder by low-temperature freeze dryer or spray drying.

[0025] 1.2 Preparation of egg yolk immunoglobulin:

[0026] 1.2.1 Egg immunization preparation: select healthy laying hens, and inject multivalent E. coli vaccines (such as K88, K99, 987P, F41 multivalent vaccines) on the breast muscles of laying hens at...

Embodiment 2

[0033] Raw materials: Chinese herbal medicine extract, egg yolk, carrier

[0034] 2.1. Preparation of Chinese herbal medicine extract: mix the Chinese herbal medicine with the weight ratio of Codonopsis pilosula, Pulsatilla pulsatillae, Radix Astragali, Banlangen, and Patrinia 1:1:1:1:1, pulverize them with a micro pulverizer and mix them, then use water as a solvent, soaking time After 60 to 90 minutes, use an ultrasonic instrument to perform ultrasonic treatment. The ultrasonic frequency is 20 to 40 kHz, and the ultrasonic treatment is 30 minutes; Element.

[0035] 2.2 Yolk preparation:

[0036] After fresh high-free eggs are disinfected with 75% alcohol, egg yolk liquid is obtained by manually beating eggs or obtained by egg white / egg yolk separator.

[0037] 2.3 Preparation of Chinese herbal medicine and egg yolk compound preparation:

[0038]After mixing the Chinese herbal medicine extract and egg yolk in the above 2.1 according to the weight ratio of 1:1 → add 20-80% ...

Embodiment 3

[0040] Raw materials: Chinese herbal medicine extract, egg yolk, egg white, carrier

[0041] 3.1 Preparation of Chinese herbal medicine extracts: Chinese herbal medicines are mixed with sophora flavescens, pulsatilla, coptis, astragalus, isatidis, Patrinia, and licorice in a weight ratio of 1:1:1:1:1:1:1, pulverized by a micro pulverizer and mixed , and then use ultrasonic to extract its active ingredients, and the soaking time before extraction is 60-90min. The ultrasonic frequency is 20-40kHz, and the ultrasonic treatment is 30min. After filtration, it is made into powder by low-temperature freeze dryer or spray drying.

[0042] 3.2 Preparation of egg yolk and egg white:

[0043] After the fresh high-free eggs are disinfected, beat the eggs to get the yolk and egg whites, and remove the eggshells.

[0044] 3.3 Preparation of Chinese herbal medicine egg yolk egg white preparation:

[0045] Proportioning the prepared Chinese herbal medicine extract with egg yolk and egg wh...

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Abstract

The invention discloses a production method of an immunoglobulin compound preparation for especially preventing and treating porcine diarrhea, and relates to the field of veterinary drugs and feed additives. The production method comprises the following steps: adding part of extracts or powder and the like to specific immunoglobulin or a substance which is not extracted and contains the specific immunoglobulin according to a certain proportion; and then evenly mixing to obtain the immunoglobulin compound preparation. By compositing the advantages of the immunoglobulin extract or powder, a novel antibiotic substitute is formed, thereby achieving the purposes of treating both symptoms and causes, accelerating the rehabilitation speed of a diarrheal animal, preventing and treating porcine diarrhea and meanwhile lowering cost; and the immunoglobulin compound preparation is a safe and hormone-free green product with special good effect on porcine diarrhea. The immunoglobulin compound preparation is taken as a feed additive or mixed with water and drunk. The immunoglobulin compound preparation is especially applicable to prevention and treatment of porcine diarrhea and also suitable for diarrheal diseases of animals such as various poultry, livestock and the like.

Description

technical field [0001] The invention relates to the field of veterinary medicine and feed additives, in particular to a production method of a Chinese herbal immunoglobulin compound preparation with special effects for preventing and treating swine diarrhea. [0002] The invention is suitable for the prevention and treatment of swine diarrhea, and is also suitable for the prevention and treatment of various poultry, livestock and other animal diarrhea diseases. Background technique [0003] Piglet diarrhea is a common infectious disease caused by porcine pathogenic E. coli, Clostridium welchii and rotavirus, transmissible gastroenteritis virus, epidemic diarrhea virus and Clostridium perfringens, including porc Acute gastroenteritis, epidemic diarrhea, porcine rotavirus disease, porcine reproductive and respiratory syndrome, swine fever, pseudorabies and circovirus enteritis, etc., have the characteristics of acute onset, rapid spread, and high mortality, which seriously end...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K39/42A61K9/14A61P1/12A61P31/04A61P31/14A61P31/20A23K1/14A23K1/18A23K10/30A23K20/147A23K40/10A23K50/30
Inventor 方希修杨廷桂王冬梅方圆
Owner 方希修
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