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Application of Eucommia lignans in preparing medicaments for preventing and treating hypertension-induced renal injury

A technology for lignans and kidney damage is applied in the application field of Eucommia lignans in the preparation of medicines for preventing and treating hypertension and kidney damage, and can solve problems such as less research on the pharmacological effects of Eucommia lignans.

Active Publication Date: 2011-10-26
CHANGSHA DUXACT BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few domestic and foreign studies on the pharmacological effects of eucommia lignans

Method used

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  • Application of Eucommia lignans in preparing medicaments for preventing and treating hypertension-induced renal injury
  • Application of Eucommia lignans in preparing medicaments for preventing and treating hypertension-induced renal injury
  • Application of Eucommia lignans in preparing medicaments for preventing and treating hypertension-induced renal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Experimental Study on Antihypertensive Renal Damage of Eucommia Lignans

[0036] Sample source: UV spectrophotometry was used to identify the content of lignans in Eucommia lignan samples prepared by extracting Eucommia ulmoides;

[0037] Conditions: detection wavelength: 277nm; 1cm optical path; reference substance: pinoresinol diglycoside (PDG). The reference substance and sample were dissolved in 50% methanol, and the blank tube was dissolved in 50% methanol.

[0038] Preparation of standard solution: Accurately weigh 5.68mg PDG, place in a 25mL volumetric flask, dissolve with 50% methanol solution and dilute to the mark, shake well to obtain 227μg / mL PDG stock solution, store in a 4°C refrigerator. The stock solution was diluted in gradient with 50% methanol to 227, 113.5, 56.75, 28.38, 14.19 μg / mL.

[0039] Preparation of sample solution: Accurately weigh 134.4mg eucommia lignan sample, place it in a 10mL volumetric flask, dissolve and dilute to the mark with 50%...

Embodiment 2

[0067] Take 2Kg of bark of Eucommia ulmoides (with the outer skin removed), extract twice with 8L of 65% ethanol under reflux, each time for 1h, filter, combine the two extracts and concentrate to 800ml. Mix and load the sample with D101 macroporous resin (column volume of macroporous resin is 3 L), wash with water for 3 times of column volume, continue to wash with 1% ammonia water for 3 times of column volume, and then wash with water until neutral. Elute with 20% ethanol for 2 column volumes and 45% ethanol for 2.5 column volumes. The 45% ethanol eluate was concentrated to 600ml. The eluate was concentrated and dried to a powder. Using pinoresinol diglucoside as a contrast, the extract has a lignan component content of 85% through ultraviolet detection, and a HPLC detection of pinoresinol diglucoside content of 12.5%; the extract is used as an active ingredient to prepare antihypertensive kidney damage medicine drug.

Embodiment 3

[0069] The bark of Eucommia ulmoides (with the outer bark removed) was chopped, extracted with 65% ethanol under reflux for 1 hour, filtered, and the extract was concentrated. After being adsorbed by HPD100 macroporous resin, wash 3 times of column volume with water, 2 times of column volume with 20% ethanol, 2 times of column volume with 45% ethanol, collect and concentrate the 45% ethanol eluate, freeze-dry to obtain extract powder. Take 60g of powder, add 230g of microcrystalline cellulose and 10g of PVP, mix well, add appropriate amount of ethanol to make soft material, granulate, dry, granulate, add a small amount of magnesium stearate, compress into tablets, and make 1000 tablets; Drugs for high blood pressure kidney damage.

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Abstract

The invention discloses an application of Eucommia lignans in preparing medicaments for preventing and treating hypertension-induced renal injury. The Eucommia lignans are extracted from Eucommia barks as raw materials and used to prepare medicaments for preventing and treating hypertension-induced renal injury. The Eucommia lignans can better improve the damage of the renal glomeruli and tubules due to spontaneous hypertension and have the pharmacological action of inhibiting the expression of type III collagen and the proliferation of mesangial cells, so as to effectively prevent and treat hypertension-induced renal injury.

Description

technical field [0001] The invention relates to the application of eucommia lignan in the preparation of medicines for preventing and treating hypertensive kidney damage in the technical field of medicine. Background technique [0002] The kidney is the most common target organ involved in hypertensive damage. In recent years, the number of patients with hypertensive kidney disease in my country is on the rise, and hypertensive kidney disease has become an important disease that endangers the health of Chinese people. Therefore, prevention and treatment of hypertensive renal damage is an important goal of hypertension prevention and treatment. Although hypertension is the initiating factor of renal target organ damage, the pathological changes of the renal target organ after the occurrence of hypertension still have their own characteristics, which are mainly manifested as glomerulosclerosis and interstitial fibrosis , the mechanism is not only related to renal ischemia-hy...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61P9/12A61P13/12
Inventor 欧阳冬生严谨李玲谷娟胡凯王珍珊王俊杰吴卫华邓晓兰李慧周应军
Owner CHANGSHA DUXACT BIOTECH CO LTD
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