Device and method for preparing gel microsphere and gel microsphere in which antitubercular agents can be injected

Abstract

The invention relates to a device and a method for preparing a gel microsphere and a gel microsphere in which antitubercular agents can be injected. The device comprises: a porous shower nozzle, a collecting cup, a collecting tubule, a high pressure static generator, a constant current pump, a settling basin, an injection pump and an infiltration electrode. On the basis of a common static liquid drop generating device, the collecting tubule is arranged to form a liquid level flow regulating system, so that a liquid exchange passage exists between the collecting cup and the settling basin and can collect the low-density gel microspheres floating on the liquid level of the collecting cup and rapidly transfer the microspheres to the settling basin. Meanwhile, the built-in infiltration electrode type porous shower nozzle can enable the drug liquid droplet in drug-carrying sol solution to be fully charged, and form a uniform high electric field with the collecting tubule, thus enhancing the atomizing effect of the liquid column of the nozzle and enabling the drug-carrying sol solution to form monodispersity gel microspheres. The gel microsphere in which antitubercular agents can be injected contains rifapentine or rifabutin, made by the device and the method. The gel microsphere is high in yield, and large in drug-carrying capacity, and does not sink down or adhere after drying.

Description

technical field [0001] The invention relates to a gel microsphere preparation technology, in particular to a low-density gel microsphere, a preparation method and a device thereof. Background technique [0002] The treatment of tuberculosis is mainly to inhibit and kill the parasitic Mycobacterium tuberculosis in cells through drugs. Commonly used drugs are rifapentine, rifampicin, and isoniazid. The first two are lipophilic drugs that are insoluble in water and easily penetrate biomembranes. However, direct oral administration is generally adopted. Rifapentine and rifampicin lipophilic drugs are less dissolved in body fluids, and the bioavailability of the drugs is not high. function causing major damage. For clinical anti-tuberculosis drug shock therapy, excessive doses in a short period of time will cause serious toxic and side effects to the body, and during the interval between each treatment, the blood elimination half-life of anti-tuberculosis drugs is less than 6 h...

AI Technical Summary

Problems solved by technology

However, it is unacceptable as a slow-release carrier for injectable drugs. Many rifampicin drugs dissolve from calcium alginate microspheres when the microspheres are prepared by the dripping method, and enter into the gel solidification solution, which directly leads to the loss of rifampicin drugs. The encapsulation rate is reduced and the production cost is increased

In addition, the relative density of the drug-loaded calcium alginate microspheres prepared by the above method is less than 1.01, which is lower than the density of the gel solidification liquid, and the rifampicin-sodium alginate microspheres produced float on the surface of the gel solidification liquid, hindering the subsequent falling. The droplets contact the gel solidification liquid, and then adhere to the subsequent small droplets to form a line or floc, which seriously affects the production speed and quality of normal gel microspheres

The above technical data also suggest that the production process of the anti-tuberculosis drug calcium alginate microspheres is relatively complicated, the encapsulation rate of the drug is low and the sustained release time of the drug is not long enough

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