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Eye pad for alleviating eye fatigue and preparation method thereof

A technology for relieving visual fatigue and eye patches, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, sheet delivery, etc. It can solve the problems of no clear therapeutic purpose, no mutagenicity of somatic cells and germ cells, etc. To achieve the effect of safety, non-toxic and side effects, avoiding the first-pass effect, and convenient use

Inactive Publication Date: 2011-08-31
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 2. Ames test, mouse bone marrow polychromatic erythrocyte micronucleus test, and mouse sperm abnormality test were all negative, showing no mutagenicity to somatic cells and germ cells;
Chinese patents such as CN00121388.1 disclose a grape seed extract OPCs strong anti-oxidation compound capsule and its manufacturing method, which is a compound health product that can delay aging and regulate the immune function of the body; CN02159540.2 uses grape seed extract as raw material The patent for capsules used in anti-aging, anti-cancer, anti-oxidation, improving cardiovascular and cerebrovascular, etc., has no specific therapeutic purpose; CN200510042958.8 uses the antioxidant properties of proanthocyanidins to treat colitis; CN200910071327.7 is Soft capsules prepared with lutein, proanthocyanidins from blueberry extract, β-carotene, inulin, chrysanthemum ketone, and wolfberry polysaccharide to relieve visual fatigue
It can be seen that there is no patented invention of proanthocyanidin health products for external use to relieve visual fatigue and prevent visual fatigue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of dosage form I OPCs eye patch

[0023] Formula: OPCs 2g, carbomer 5g, sodium carboxymethylcellulose 1.5g, polyvinyl alcohol 1.5g, triethanolamine 10ml, polyacrylic resin pressure-sensitive adhesive 10g, citric acid 3g, glycerin 80g, 1,2-propylene glycol 80g .

[0024] Preparation method: 1. Carbomer, sodium carboxymethyl cellulose, and polyvinyl alcohol are respectively swelled with water, dissolved in a water bath, and mixed. Add triethanolamine, polyacrylic resin pressure-sensitive adhesive, citric acid, glycerin and 1, 2-propanediol and stir evenly. 2. Disperse OPCs with 4 mL of purified water and mix with the above matrix evenly to obtain a drug-adhesive solution. 3. Coat the glue on the backing layer, dry in an oven at 50°C for 40 minutes, then dry at 60°C for 2 hours until the surface is cured and elastic, then cover with an anti-adhesive layer, and then cut into 4cm*2cm oval eye patch, Instant OPCs eye patch. 4. Pack into bags, 2 stick...

Embodiment 2

[0027] Example 2 Preparation of dosage form II OPCs eye patch

[0028] Formula: OPCs 2g, carbomer 3g, sodium carboxymethylcellulose 0.8g, polyvinyl alcohol 1.2g, triethanolamine 10ml, polyacrylic resin pressure-sensitive adhesive 8g, citric acid 2g, glycerin 70g, 1,2-propylene glycol 60g .

[0029] Preparation method: 1. Carbomer, sodium carboxymethyl cellulose, and polyvinyl alcohol are respectively swelled with water, dissolved in a water bath, and mixed. Add triethanolamine, polyacrylic resin pressure-sensitive adhesive, citric acid, glycerin and 1, 2-propanediol and stir evenly. 2. Disperse OPCs with 4 mL of purified water and mix with the above matrix evenly to obtain a drug-adhesive solution. 3. Coat the glue on the backing layer, dry it in an oven at 50°C for 40 minutes, then dry it at 60°C for 2 hours until the surface is cured and elastic, then cover with an anti-adhesive layer, and then cut it into 4cm*2cm oval eye patches. Instant OPCs eye patch. 4. Pack into ba...

Embodiment 3

[0032] Example 3 Preparation of dosage form III OPCs eye patch

[0033] Recipe: OPCs 2g, carbomer 7g, sodium carboxymethylcellulose 2g, polyvinyl alcohol 1.8g, triethanolamine 10ml, polyacrylic resin pressure-sensitive adhesive 12g, citric acid 3g, glycerin 100g, 1,2-propylene glycol 80g.

[0034] Preparation method: 1. Carbomer, sodium carboxymethyl cellulose, and polyvinyl alcohol are respectively swelled with water, dissolved in a water bath, and mixed. Add triethanolamine, polyacrylic resin pressure-sensitive adhesive, citric acid, glycerin and 1, 2-propanediol and stir evenly. 2. Disperse OPCs with 4 mL of purified water and mix with the above matrix evenly to obtain a drug-adhesive solution. 3. Coat the glue on the backing layer, dry it in an oven at 50°C for 40 minutes, then dry it at 60°C for 2 hours until the surface is cured and elastic, then cover with an anti-adhesive layer, and then cut it into 4cm*2cm oval eye patches. Instant OPCs eye patch. 4. Pack into bags, ...

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PUM

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Abstract

The invention relates to an eye pad for alleviating eye fatigue, which is prepared from proanthocyanidin serving as an active material, and a preparation method thereof, belonging to the technical field of health care products. The prescription of the OPCs (Proanthocyanidin) eye pad provided by the invention comprises 2g of OPCs, 3-7 g of Carbomer, 0.8-2 g of sodium carboxymethylcellulose, 0.8-2 g of polyvinyl alcohol, 10 ml of triethanolamine, 7-15 g of polyacrylic resin pressure-sensitive adhesive, 2-4 g of citric acid, 60-100 g of glycerin and 60-100 g of 1,2-propylene glycol. The eye pad has a better curative effect on symptoms like eye fatigue, dry eyes, itchy eyes and the like caused by eye strains.

Description

technical field [0001] The invention relates to a preparation method and formula combination of an eye patch for relieving visual fatigue prepared by using proanthocyanidins as an active substance, and belongs to the technical field of health care products. Background technique [0002] Asthenopia, also called asthenopia syndrome, is caused by the voluntary efforts of the optic apparatus to obtain clear vision with insufficient accommodation, such as blurred vision, eye swelling, eye pain, headache, shoulder and back pain, and mental fatigue Post-symptom group. With the rapid development of the information age and the acceleration of the pace of life, especially video display terminals (VDTs) such as computers, TVs, game consoles, and monitors have been gradually integrated into people's work, study, and family life. Common diseases seriously affect people's life. It is not an independent disease, but a group of fatigue syndromes caused by various reasons. At present, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/353A61P27/02
Inventor 赵余庆史彩虹
Owner SHENYANG PHARMA UNIVERSITY
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