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Polyethylene glycol-copolyester segmented copolymer material capable of preventing adhesion, a preparation method and application thereof

A polyethylene glycol and block polymer technology, applied in medical science, surgery, etc., can solve the problems of pH imbalance, aseptic inflammatory reaction, irritation, etc., achieve good biocompatibility, convenient operation and application, good biocompatibility

Inactive Publication Date: 2011-05-18
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poloxamer is one of them, but this block polymer composed of polyethylene glycol (PEG) and polypropylene glycol (PPG) is not biodegradable, and the gel maintains a special time in the body. Short (generally less than 3 days), so not very effective as a barrier to prevent adhesions
Chinese patents with application numbers 200910304210.9 and 201010138739.0 propose a triblock copolymer composed of PEG and polycaprolactone (PCL) as a temperature-sensitive gel material for postoperative anti-adhesion. However, the aqueous solution of this type of material is not Stable, due to the crystallinity of the PCL block, the aqueous solution of this kind of material will spontaneously gel at room temperature, which brings a lot of inconvenience in the preparation and storage of the gel
Chinese patent application number 201010133541.3 reported a diblock polymer thermosensitive gel composed of monomethoxy-terminated polyethylene glycol (MPEG) and polylactic acid (PLA). Although its solution stability was improved, a large number of The acidic degradation product of the PLA block, lactic acid, has a certain degree of stimulation to the tissue, which will lead to a local pH imbalance, thereby triggering an aseptic inflammatory response, which may affect the healing of the wound.

Method used

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  • Polyethylene glycol-copolyester segmented copolymer material capable of preventing adhesion, a preparation method and application thereof
  • Polyethylene glycol-copolyester segmented copolymer material capable of preventing adhesion, a preparation method and application thereof
  • Polyethylene glycol-copolyester segmented copolymer material capable of preventing adhesion, a preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1: Synthesis of PCLA-PEG-PCLA block copolymer

[0034]Add 28 g of PEG (molecular weight: 1500) into a 500 ml three-neck flask, heat the oil bath to 120 oC, and vacuum pump for three hours while stirring to remove residual moisture in the PEG. In order to reduce the volatilization of CL monomer, firstly lower the temperature to 80 oC, then add 28 g of caprolactone (CL) and 36 g of lactide (LA) under the protection of argon, heat it under vacuum to make it melt completely, and then continue to remove water for an hour. Add 15 mg of stannous isooctanoate, and the oil bath is heated to 130° C. to continue the reaction for 12 hours. After the reaction is complete, dissolve the initial product in cold water (5 oC ~ 8 oC). After it is completely dissolved, the temperature of the solution is raised to 80 oC, the product precipitates, and the upper solution is removed. Repeat the above steps once to obtain the initial product. Water was removed by lyophilization in ...

Embodiment 2

[0035] Example 2: Poly(caprolactone 1,4,8-trioxaspiro[4.6]-9-undecanone)-polyethylene glycol-poly(caprolactone-1,4,8-trioxa spiro[4.6]-9-undecanone) P(CL-TOSUO)- b -PEG- b - Synthesis of P(CL-TOSUO)

[0036] Add 15 g of PEG (molecular weight: 1500) into a 500 ml three-neck flask, heat the oil bath to 120 oC, and vacuum pump for three hours while stirring to remove the residual moisture in the PEG. In order to reduce the volatilization of CL monomer, the temperature was first lowered to 80 oC, and then 33 g of caprolactone (CL) and 10 g of 1,4,8-trioxaspiro[4.6]-9- Undecanone TOSUO, after heating under vacuum to completely melt, continue to remove water for one hour. Add 15 mg of stannous isooctanoate, and the oil bath is heated to 130° C. to continue the reaction for 12 hours. After the reaction is complete, dissolve the initial product in cold water (5 oC ~ 8 oC). After it is completely dissolved, the temperature of the solution is raised to 80 oC, the product precipitate...

Embodiment 3

[0037] Example 3: Synthesis of polycaprolactone-glycolide-polyethylene glycol-polycaprolactone-glycolide (PCGA-PEG-PCGA) block copolymer

[0038] Add 14 g PEG (molecular weight 1500) into a 500 ml three-neck flask, heat the oil bath to 120 oC, and vacuum pump for three hours while stirring to remove the residual moisture in the PEG. In order to reduce the volatilization of CL monomer, firstly lower the temperature to 80 oC, then add 14 g caprolactone (CL) and 18 g glycolide (GA) under the protection of argon, heat it under vacuum to make it melt completely, and then continue to remove water for an hour. Add 15 mg of stannous isooctanoate, and the oil bath is heated to 130° C. to continue the reaction for 12 hours. After the reaction is complete, dissolve the initial product in cold water (5 oC ~ 8 oC). After it is completely dissolved, the temperature of the solution is raised to 80 oC, the product precipitates, and the upper solution is removed. Repeat the above steps once t...

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Abstract

The invention belongs to the technical field of a high-molecular material and medical treatment, and particularly relates to a medical high-molecular material with an anti-adhesion characteristic, a preparation method and application thereof. The medical high-molecular material is a solution system of a segmented copolymer material formed by connecting a polyethylene glycol hydrophilic chain segment and a copolyester hydrophobic chain segment, wherein the copolyester hydrophobic chain segment is formed by copolymerizing two or more than two of glycolide, lactide, caprolactone, 1,4,8-trioxaspiro [4.6]-9-hendecanone and para-dioxanone. The solution system of the segmented copolymer material has a temperature sensitive characteristic and spontaneously forms a gel under the body temperature. The material has an effect of preventing wound surface adhesion after being coated on the postoperative would surface.

Description

technical field [0001] The invention belongs to the technical field of degradable biomaterials and medical implant materials, and in particular relates to a medical polymer material with anti-adhesion properties and its preparation method and application. Background technique [0002] Postoperative adhesion is an important problem that has plagued the surgical field for a long time. Adhesions after abdominal surgery can lead to a series of complications such as pelvic pain, intestinal obstruction, and infertility; in tendon repair surgery, adhesions can lead to motor dysfunction in patients. At present, there are many ways to prevent postoperative adhesions, including the improvement of surgical methods, the application of local drugs after surgery, the application of local barrier materials after surgery, and appropriate activities in the early postoperative period and exercise in the later period. Among them, degradable and absorbable barrier materials have received more ...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/16C08G65/48C08G63/664
Inventor 丁建东张正俞麟
Owner FUDAN UNIV
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