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Method for grafting 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on titanium-base material surface

A technology of methacryloyloxyethylphosphorylcholine and surface grafting, which is applied in medical science, prostheses, coatings, etc., can solve problems such as poor binding force, difficulty in achieving anticoagulant effect, and loss, and achieve Improved binding force, excellent anticoagulant performance, and not easy to fall off

Inactive Publication Date: 2011-04-06
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art adopts a simple physical coating method to adsorb MPC polymer on the surface of titanium-based materials. The binding force between the two is poor, and because the phosphorylcholine polymer has a certain water solubility, it will be lost in the blood flow environment, which is difficult. To achieve the expected anticoagulant effect

Method used

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  • Method for grafting 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on titanium-base material surface

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Embodiment 1

[0032] A method for grafting 2-methacryloyloxyethyl phosphorylcholine polymer on the surface of a titanium-based material, the steps of which are:

[0033] The titanium-based material is pretreated first, and the specific method of pretreatment is: the titanium-based material-pure titanium, after polishing, it is cleaned with deionized water, acetone, and ethanol in sequence; then the titanium-based material is placed in a 5.0mol / In a NaOH solution of L, heat at 60°C for 6 hours; then place in deionized water, keep warm at 80°C for 12 hours, take it out; After drying; perform the following operations:

[0034] A, soaking and heating Under the protection of nitrogen, the pure titanium material is soaked in anhydrous tetrahydrofuran solution of 11-hydroxyundecylphosphonic acid (HUPA) at a temperature of 25 ° C and a concentration of 10 mmol / L for 12 hours; The final titanium-based material was heated at 120°C for 10 hours;

[0035] The organic phosphonic acid solution in this...

Embodiment 2

[0047] A method for grafting 2-methacryloyloxyethyl phosphorylcholine polymer on the surface of a titanium-based material, the steps of which are:

[0048] A, soaking and heating the titanium-based material-Ti0 2 The material was soaked in anhydrous tetrahydrofuran solution of 11-hydroxyundecylphosphonic acid (HUPA) at a temperature of 25 °C and a concentration of 10 mmol / L for 12 hours; the soaked titanium-based material was heated at 120 °C for 10 Hour;

[0049] B, repeat step A operation 4 times, obtain the unimolecular self-assembly layer of organic phosphonic acid (11-hydroxyl undecyl phosphonic acid) on the titanium-based material surface;

[0050] C, bromine isobutyrylation on the surface of titanium-based materials The titanium-based materials obtained in step B are put into anhydrous tetrahydrofuran solution with a concentration of 0.5mg / ml bromoisobutyryl bromide under the protection of argon, and then add molar The amount of triethylamine that is 1.2 times that of...

Embodiment 3

[0053] A method for grafting 2-methacryloyloxyethyl phosphorylcholine polymer on the surface of a titanium-based material, the steps of which are:

[0054] The titanium-based material is pretreated first, and the specific method of pretreatment is: the titanium-based material-pure titanium, after polishing, is ultrasonically cleaned with deionized water, acetone, and ethanol in sequence; then heated at 160°C for 10 hours. Then do the following:

[0055] A, immersion and heating Soak the pure titanium material in the anhydrous tetrahydrofuran solution of organic phosphonic acid-11-hydroxyundecylphosphonic acid (HUPA) at a temperature of 25°C and a concentration of 10mmol / L for 12 hours; The titanium-based material was heated at 120°C for 10 hours;

[0056] B, repeat step A operation 4 times, obtain the unimolecular self-assembly layer of organic phosphonic acid (11-hydroxyl undecyl phosphonic acid) on the titanium-based material surface;

[0057] C, bromine isobutyrylation on...

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Abstract

The invention discloses a method for grafting 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on a titanium-base material surface. A layer of middle bridging groups, namely organic phosphate or phosphate monoester which respectively forms chemical bonding with the titanium-base material surface and the MPC polymer is prepared on the titanium-base material surface and the MPC polymer by a self-assembled monolayer method; and the MPC polymer is grafted on the titanium-base material surface by a surface-initiated atom transfer radical polymerization method. In the prepared simulative functionalized titanium-base material of the method, the MPC polymer on the surface of the simulative functionalized titanium-base material has strong bonding force with the titanium-base material and has better histocompatibility and better blood compatibility. The invention has simple process and is easy to realize.

Description

technical field [0001] The invention relates to a method for biomimetic modification on the surface of a titanium-based material, in particular to a method for grafting 2-methacryloyloxyethyl phosphorylcholine polymer on the surface of a titanium-based material. Background technique [0002] Metal materials such as medical stainless steel, titanium, tantalum, nickel-titanium alloy or cobalt-based alloy have been widely used in clinical treatment. When implants made of metal materials are implanted in the human body, coagulation will occur in contact with blood, which will affect the fluidity of blood. The existence of coagulation will seriously affect the health of patients and even endanger their lives. Improving the anticoagulant performance of the surface of metal materials is the key technology to solve this problem. [0003] Titanium-based materials are important medical metal materials. The chemical composition of the surface, critical surface tension, interfacial ene...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06
Inventor 赵元聪黄楠张晓熊开琴冷永祥杨苹王进陈俊英孙鸿吴熹景凤娟
Owner SOUTHWEST JIAOTONG UNIV
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