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Compound brain protection preparation and preparation method thereof

A preparation and antioxidant technology, applied in the field of medicine, can solve the problems of complex pathogenesis, no specific treatment method, high mortality and disability rate, etc., achieve simple preparation process, reduce the consumption of SOD vitality, and reduce lipid peroxidation damage effect

Active Publication Date: 2011-02-09
XIAN LIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cerebrovascular-related diseases are caused by a variety of brain injury mechanisms involved in their pathological development process. The pathogenesis is complex, and the mortality and disability rates are extremely high. Currently, there is no specific treatment method

Method used

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  • Compound brain protection preparation and preparation method thereof
  • Compound brain protection preparation and preparation method thereof
  • Compound brain protection preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1 A kind of formula of compound brain protection injection water injection and its preparation process

[0061] formula:

[0062]

[0063] Preparation Process:

[0064] First, under clean conditions, add 20ml of ethanol and 30ml of propylene glycol into 50ml of water for injection according to the above formula, mix well and then add 50ml of water for injection to set the volume to 100ml; then saturate with nitrogen for 1 hour; accurately weigh 300mg of sulfurous acid Dissolve sodium hydrogen and 10 mg EDTA in the above solution; then accurately measure 150 mg edaravone and 20 mg nimodipine, and dissolve them by ultrasonic. Decolorize, filter with a 0.22 μm microporous membrane, seal in an ampoule bottle with nitrogen gas, and sterilize with damp heat at 121°C for 15 minutes.

Embodiment 2

[0065] Embodiment 2 A formula of compound brain protection freeze-dried powder injection and its preparation process

[0066] formula:

[0067]

[0068]

[0069] Preparation Process:

[0070] First, under clean conditions, add 20ml of ethanol and 30ml of propylene glycol into 50ml of water for injection according to the above formula, mix well and then add 50ml of water for injection to make up to 100ml; then saturate with nitrogen for 1 hour; accurately weigh 300mg of bisulfite Dissolve sodium, 10mg EDTA, and 500mg mannitol in the above solution; then accurately measure 150mg edaravone and 20mg nimodipine, and dissolve them by ultrasonic. After adding 0.3% charcoal for needles to treat, filter with a microporous membrane, the obtained pyrogen-free clear liquid is divided into sterile vials and prepared according to the freeze-drying process.

Embodiment 3

[0071] Embodiment 3 A kind of formula of compound brain-protecting fat emulsion injection and its preparation process (low drug content)

[0072] formula:

[0073]

[0074] Preparation Process:

[0075] Take 10g of soybean oil, under the condition of nitrogen protection, stir magnetically at about 70°C, completely dissolve 1.2g of egg yolk lecithin, then add 100mg of edaravone, 10mg of nimodipine and 0.1g of vitamin E, heat and stir to dissolve, An oily phase is formed. Dissolve 1g of glycerin and 0.01g of EDTA in 80ml of water for injection while heating to about 70°C. Under the condition of 8000r / min high-speed shearing, the oil phase was slowly added to the water phase, and at the same time, shearing was carried out under nitrogen protection for 20 minutes to obtain colostrum, and the volume was adjusted to 100ml with water for injection. Adjust the pH of the colostrum to between 7 and 9 with a pH regulator. Homogenize for 8-9 times with a high-pressure homogenizer u...

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Abstract

The invention relates to the medical field, in particular to a compound brain protection preparation and a preparation method thereof. The preparation contains active pharmaceutical ingredients and pharmaceutically acceptable carriers, wherein the active pharmaceutical ingredients comprise edaravone and nimodipine according to a mass ratio of 2-30: 1-3. The preparation can protect the brain by acting on a plurality of links of cerebral injury through different mechanisms. Compared with the single pharmaceutical preparation, the preparation can better prevent and cure associated cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a compound preparation, in particular to a compound brain-protective preparation with edaravone and nimodipine as main active pharmaceutical ingredients and a preparation method thereof. Background technique [0002] Cerebrovascular-related diseases are caused by a variety of brain injury mechanisms involved in their pathological development. The pathogenesis is complex, and the mortality and disability rates are extremely high. Currently, there is no specific treatment. The neuroprotective treatment of the ischemic penumbra in acute stroke has always been a hot topic in neurology. Studies have found that the pathological reaction of oxygen free radicals, calcium overload, and the toxic effects of excitatory amino acids are different pathological processes in brain injury, but they are related to each other. According to different pathological mechanisms, looking for protective mea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4152A61P25/00A61K9/19A61K9/107A61K9/08A61P39/06A61K31/4422A61P9/10
Inventor 王汝涛陈涛胡惠静王惟娇张阳
Owner XIAN LIBANG PHARMA
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