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Preparation method of tylosin tartrate microspheres

A technology of tylosin tartrate and microspheres is applied in the field of preparation of tylosin tartrate microspheres, which can solve the problems of short elimination half-life and frequent medication, achieve no immunogenicity, prolong elimination half-life, and be easy to popularize and apply Effect

Active Publication Date: 2012-07-25
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the conventional dosage form of the drug has a short elimination half-life, frequent medication, and wide distribution in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] In the method for preparing tylosin tartrate microspheres of this embodiment, every 1 g of tylosin tartrate is prepared according to the following steps:

[0014] 1) Take 1g of gelatin, add secondary water to make 5mL gelatin solution, swell it completely in a warm water bath at 50℃, then add 1g of tylosin tartrate, stir evenly to obtain the water phase;

[0015] 2) Take 24mL of liquid paraffin and 1.0-2.0% of Span-80 6mL and mix them to obtain 30mL of oil phase;

[0016] 3) Add the water phase obtained in step 1) to the oil phase obtained in step 2), stir evenly at a speed of 500 r / min, cool to 5°C, and add 2 mL of glutaraldehyde cross-linking agent for cross-linking and curing , Curing time is 20 minutes;

[0017] 4) Wash off the excess crosslinking agent with isopropanol, then wash off the liquid paraffin on the surface of the microspheres with petroleum ether, and vacuum dry to obtain tylosin tartrate microspheres.

[0018] It is determined that the GMS powder has good round...

Embodiment 2

[0020] In the method for preparing tylosin tartrate microspheres of this embodiment, every 1 g of tylosin tartrate is prepared according to the following steps:

[0021] 1) Take 0.8g of gelatin, add secondary water to make 5mL gelatin solution, swell it completely in a warm water bath at 50℃, then add 1g of tylosin tartrate, stir well to obtain the water phase;

[0022] 2) Take 25mL of liquid paraffin and 1.0-2.0% Span-80 5mL and mix them to obtain 30mL oil phase;

[0023] 3) Add the water phase obtained in step 1) to the oil phase obtained in step 2), stir evenly at a speed of 600 r / min, cool to 4°C, and add 3 mL of glutaraldehyde cross-linking agent for cross-linking and curing , Curing time is 30 minutes;

[0024] 4) Wash off the excess crosslinking agent with isopropanol, then wash off the liquid paraffin on the surface of the microspheres with petroleum ether, and vacuum dry to obtain tylosin tartrate microspheres.

[0025] The microsphere powder with good roundness was prepared, ...

Embodiment 3

[0027] In the method for preparing tylosin tartrate microspheres of this embodiment, every 1 g of tylosin tartrate is prepared according to the following steps:

[0028] 1) Take 1.5g of gelatin, add secondary water to make 5mL gelatin solution, swell it completely in a warm water bath at 50℃, then add 1g of tylosin tartrate, stir evenly to obtain the water phase;

[0029] 2) Take 30mL of liquid paraffin and 1.0-2.0% Span-80 5mL and mix them to obtain 35mL oil phase;

[0030] 3) Add the water phase obtained in step 1) to the oil phase obtained in step 2), stir evenly at a speed of 800 r / min, cool to 3°C, and add 4 mL of glutaraldehyde cross-linking agent for cross-linking and curing , Curing time is 40 minutes;

[0031] 4) Wash off the excess crosslinking agent with isopropanol, then wash off the liquid paraffin on the surface of the microspheres with petroleum ether, and vacuum dry to obtain tylosin tartrate microspheres.

[0032] The GMS microsphere powder was tested, and its roundnes...

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Abstract

The invention discloses a preparation method of tylosin tartrate microspheres. The method uses gelatin as the carrier, liquid paraffin and Span-80 as the oil phase, and glutaraldehyde as the crosslinking agent to prepare tylosin tartrate microspheres. The tylosin tartrate microspheres prepared by the invention use gelatin as the carrier material, have no adverse reactions and no immunogenicity, have biodegradability and wide application range and can be taken by mouth or through injection. liquid paraffin and Span-80 are used as the oil phase, thus increasing the drug-loading rate and the encapsulation rate, facilitating the crosslinking and curing of glutaraldehyde, prolonging the elimination half life of the microsphere medicine and performing drug controlled release in animals. In addition, the preparation method of the invention has simple operation, the adopted reagent is common, the preparation cost is lower and the method is easy to popularize and apply.

Description

technical field [0001] The invention relates to a preparation method of tylosin tartrate microspheres, belonging to the technical field of veterinary medicine. Background technique [0002] In recent years, with the development of large-scale and intensive pig farming, the frequent introduction of breeds in different regions and countries has led to an increase in pig respiratory diseases, which has become a major problem in pig farming. Among them, swine asthma, porcine reproductive and respiratory syndrome, porcine circovirus type 2, and swine influenza virus are common in China, causing economic losses to farmers. People have carried out a lot of reports for the treatment of porcine respiratory disease, and proposed a lot of treatment schemes to the disease, but because the complexity of the cause of the disease and the multiple of the disease, it brings difficulties to the treatment, and the treatment effect is not good. And the prognosis is bad. Tylosin is commonly us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/7048A61K47/42A61K47/44A61K47/22A61P31/04A61K47/06
Inventor 李建正吴红云班曼曼
Owner ZHENGZHOU HOUYI PHARMA
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