Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bone repair implant coated with strontium-doped calcium polyphosphate coating and preparation method thereof

A strontium calcium polyphosphate and bone repair technology, applied in coatings, prostheses, dental preparations, etc., can solve problems such as poor biocompatibility, poor combination of biological tissue and matrix, and achieve good high temperature stability and good biological activity , Strong osteoinductive effect

Inactive Publication Date: 2010-12-29
成都华西一为生物植体科技有限公司
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the purpose of the present invention is to provide a new implant for bone repair coated with a strontium-doped calcium polyphosphate coating and a preparation method thereof, so as to solve the problem of metal implants prepared by the prior art. There are problems such as poor biocompatibility, poor combination of biological tissue and matrix, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bone repair implant coated with strontium-doped calcium polyphosphate coating and preparation method thereof
  • Bone repair implant coated with strontium-doped calcium polyphosphate coating and preparation method thereof
  • Bone repair implant coated with strontium-doped calcium polyphosphate coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Weigh the required CaCO according to the molar ratio of calcium to strontium 98:2 3 , SrCO 3 (analytical pure) and the amount of phosphoric acid (85%), wet preparation of hydrated calcium dihydrogen phosphate (Ca(H2PO4) 2 ·H 2 O, referred to as CPMM) solution, using a rotary evaporator to steam the CMPP powder. Heat the dried CMPP powder to about 500°C to heat-preserve and polymerize to form strontium-doped calcium polyphosphate (SCPP), then raise the temperature to about 1200°C to obtain SCPP melt, quench in ice water to obtain amorphous SCPP burnt material, dry and grind to obtain Pass 100 mesh powder, heat the powder to about 700°C and keep it warm for about 4 hours to obtain β-SCPP, and then grind it for the second time after natural cooling, take 150 mesh-300 mesh (50-100μm) β-SCPP powder for spraying .

[0033] (2) After roughening the surface of the titanium substrate, the spraying process parameters are shown in Table 1:

[0034] Table 1

[0035] ...

Embodiment 2

[0040] (1) Weigh the required CaCO according to the molar ratio of calcium to strontium 99:1 3 , SrCO 3 (analytical pure) and the amount of phosphoric acid (85%), wet preparation of hydrated calcium dihydrogen phosphate (Ca(H2PO4) 2 ·H 2O, CPMM) solution, use the rotary evaporator to steam the CMPP powder. Heat the dried CMPP powder to about 500°C to heat-preserve and polymerize to generate SCPP, then raise the temperature to about 1200°C to obtain SCPP melt, quench in ice water to obtain amorphous SCPP burnt, and grind to obtain over 100 mesh powder after drying. Heat the powder to 750°C and keep it warm for about 4 hours to obtain β-SCPP. After cooling down naturally, grind it for the second time. Take 150-300 mesh (50-100μm) powder for spraying.

[0041] (2) After roughening the surface of the titanium substrate, the spraying process parameters are shown in Table 2:

[0042] Table 2

[0043] Current (A)

400

Voltage (V)

62

working atm...

Embodiment 3

[0047] (1) Weigh the required CaCO according to the molar ratio of calcium to strontium 95:5 3 , SrCO 3 (analytical pure) and the amount of phosphoric acid (85%), wet preparation of hydrated calcium dihydrogen phosphate (Ca(H2PO4) 2 ·H 2 O, CPMM) solution, use the rotary evaporator to steam the CMPP powder. Heat the dried CMPP powder to about 500°C to heat-preserve and polymerize to generate SCPP, then raise the temperature to about 1200°C to obtain SCPP melt, quench in ice water to obtain amorphous SCPP burnt, and grind to obtain over 100 mesh powder after drying. Heat the powder to about 800°C and keep it warm for about 3.5 hours to obtain β-SCPP. After cooling down naturally, grind it for the second time, and take 150-300 mesh (50-100μm) powder for spraying.

[0048] (2) After roughening the surface of the titanium substrate, the spraying process parameters are shown in Table 3:

[0049] table 3

[0050] Current (A)

450

Voltage (V)

66.7

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a bone repair implant coated with a strontium-doped calcium polyphosphate coating and a preparation method thereof. The implant is titanium metal of which a surface is coated with the strontium-doped calcium polyphosphate (SCPP) coating. The preparation method mainly comprises the following steps of: (1) spraying 150 to 300-mesh strontium-doped calcium polyphosphate powder to the surface of a titanium metal substrate to form the coating in a way of blowing the powder over a plasma flame by using plasma spraying equipment, and after coating the surface of the titanium metal substrate fully, cooling the titanium metal substrate naturally to obtain a primary product of the implant material; and (2) cleaning and drying the primary product of the implant material, preserving the heat and annealing the primary product at 700 to 800 DEG C, and after full annealing, cooling the primary product slowly to obtain the prepared implant product. The implant disclosed by the invention has higher bioactivity and the functions of promoting osteocyte growth and vascularization, can improve interface compatibility between the implant and tissues and promote synostosis, can be used as a bone repair material and an oral dental implant, and is easy to popularize commercially.

Description

technical field [0001] The invention relates to a biomedical material implanted in a human body in bone / tooth defect restoration treatment, more specifically relates to a titanium metal-based implant material and a preparation method thereof, and belongs to the technical field of biomedical materials. Background technique [0002] Metal implants are widely used in the field of bone injury or oral tooth injury restoration treatment, such as artificial joints and dental implants. Metal implants are implanted into the human body to repair bone damage or oral cavity tooth damage. The key to the success of the implant surgery is whether the implant can quickly grow to the surface of the implant and be firmly attached to the surface after it is implanted into the bone tissue. combined. The currently used titanium metal implants need a long time to heal and grow in the human body to form a firm bond with the surrounding bone tissue, and the tissue bonding surface between the impla...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/06A61K6/033A61K6/04A61K6/02A61K6/838
Inventor 吴大怡王启光万昌秀陈志宁
Owner 成都华西一为生物植体科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com