Hepatocyte growth-promoting factor enteric-coated capsule

Abstract

The invention relates to a hepatocyte growth-promoting factor enteric-coated capsule which is prepared from hepatocyte growth-promoting factor and a pharmaceutically acceptable enteric-coated capsule as the auxiliary material. The invention also discloses a preparation process and application of the enteric-coated capsule. The product, which is processed by gel chromatography, has the advantages of less impurities and higher product purity. Compared with the hepatocyte growth-promoting factor in the market, the invention enhances the activity by about 70%.

Description

technical field [0001] The invention relates to hepatocyte growth-stimulating hormone, especially the enteric-coated capsule of hepatocyte growth-stimulating factor, its preparation process and application. Background technique [0002] According to the pathology of severe viral hepatitis, severe hepatitis refers to hepatitis with hepatic encephalopathy as the main manifestation on the basis of rapid and extensive liver cell degeneration, necrosis and high-grade liver function damage. At present, viral proteins and their variation, host CTL response, macrophages, various cytokines, liver cell apoptosis, and coagulation system factors are considered to be the molecular mechanisms that cause severe hepatitis. Under certain conditions, hepatitis virus can cause abnormal host immune response, causing massive necrosis and severe degeneration of liver cells, leading to failure of liver cell function, and the resulting endotoxemia will further aggravate liver cell damage and make l...

AI Technical Summary

Problems solved by technology

Its disadvantages are as follows: 1. It must be dissolved in warm water and taken after mixing. Overheating will affect the activity of the polypeptide in it and affect the efficacy of the medicine; 2. The granules pass through the stomach in the form of a solution, and the active substances are easily degraded by gastric acid and gastric enzymes in the gastric juice. Activity, pharmacological effect are thus affected, greatly weakening therapeutic effect; 3. Due to the above reasons, according to literature reports, the bioavailability of granules after oral administration is only 4.8%, making its dosage far greater than that of injections, prolonging the treatment cycle, and relative price Greatly improved; 4. When patients take it, they can hardly bear the fishy smell produced by drug dissolution, which can easily cause nausea and vomiting. Therefore, the use of granules is greatly restricted. Although this dosage form has been on the market for many years, it has not been able to open the market.

Images