Preparation process of bone peptide soft capsule

A preparation process and soft capsule technology, which is applied in the field of bone peptide soft capsule preparation process, can solve problems such as low solid content, affecting product efficacy, and unfavorable human health, achieving reduced dosage, improved functional curative effect, and dissolution speed fast effect

Active Publication Date: 2012-09-12
四川新渔现代生物技术有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the biggest shortcoming of soft capsules is: prepare soft capsules with water-soluble solids as the main ingredient, because it is difficult to dissolve in oil, so the content of water-soluble solids in the soft capsule content is difficult to improve (usually controlled at 10-30 % (wt)), and a large amount of emulsifier needs to be added to prevent the water-soluble solids from settling and delaminating, which will affect the fluidity of the soft capsule contents, thereby affecting the compression molding ...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] (1) Preparation of extract powder: After getting 500g Drynaria fortunei, 150g turmeric, and 100g licorice and mixing them, boil and extract with water as dissolved coal, filter, concentrate, and spray-dry the water extract to obtain extract powder;

[0014] (2) Take 5 g of the above extract powder, 5 g of chondroitin sulfate, and 5 g of calcin peptide, and pulverize them through a 180-mesh sieve through an ultrafine pulverizer to obtain micropowder;

[0015] (3) Take 1g of beeswax and 16g of corn oil and heat together to obtain wax oil after the beeswax is fully melted, stir with a blender, the speed of the blender is not lower than 3000 rpm, and when the temperature of the wax oil drops to 60°C, step (2) ) the obtained micropowder is slowly added in the wax oil, at this time, due to the addition of the micropowder, the mixture gradually cools down to form a paste, continue to stir, then slowly add 4g of corn oil, dilute the paste, and stir evenly to obtain a good fluidi...

Embodiment 2

[0017] (1) Preparation of extract powder: After getting 500g Drynaria fortunei, 150g turmeric, and 100g licorice and mixing them, boil and extract with water as dissolved coal, filter, concentrate, and spray-dry the water extract to obtain extract powder;

[0018] (2) Take 18g of the above-mentioned extract powder, 18g of chondroitin sulfate, and 8g of calcium protein peptide, and pulverize them through a 180-mesh sieve through an ultrafine pulverizer to obtain a micropowder;

[0019] (3) Take 5g of beeswax and 28g of corn oil and heat together to obtain wax oil after the beeswax is fully melted, stir with a blender, the speed of the blender is not lower than 3000 rpm, and when the temperature of the wax oil drops to 60°C, the wax oil obtained in step 2 Slowly add the micro powder into the wax oil. At this time, due to the addition of the micro powder, the temperature of the mixture gradually cools down to form a paste. Continue to stir, then slowly add 7g of corn oil to dilute...

Embodiment 3

[0021] (1) Preparation of extract powder: After getting 500g Drynaria fortunei, 150g turmeric, and 100g licorice and mixing them, boil and extract with water as dissolved coal, filter, concentrate, and spray-dry the water extract to obtain extract powder;

[0022] (2) Take 30 g of the above-mentioned extract powder, 30 g of chondroitin sulfate, and 10 g of calcium protein peptide, and pulverize through a 180-mesh sieve through an ultrafine pulverizer to obtain a micropowder;

[0023] (3) Take 8g of beeswax and 40g of corn oil and heat together to obtain wax oil after the beeswax is fully melted, stir with a blender, the speed of the blender is not lower than 3000 rpm, and when the temperature of the wax oil drops to 60°C, the wax oil obtained in step 2 Slowly add the micro powder into the wax oil. At this time, due to the addition of the micro powder, the mixture gradually cools down to form a paste. Continue to stir, then slowly add 10g of corn oil to dilute the paste and stir...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation process of a bone peptide soft capsule, which is prepared by pressing and forming capsule contents on a soft capsule machine, wherein the capsule contents comprise the following raw materials in parts by weight: 5-30 parts of extract powder, 5-30 parts of chondroitin sulfate, 5-10 parts of protein calcium peptide, 1-8 parts of beewax and 20-50 parts of vegetable oil. The preparation process comprises the following steps: by using a principle that the beewax is subject to gradual temperature reduction below a melting point and is cured, slowly dispersing micro powder into mixed solution of the beewax and the vegetable oil to form powder-to-oil cream-shaped contents under highly stirring; and properly diluting the contents with the vegetable oil to forma cream with better flowability, wherein the cream is easily pressed into capsules. The invention has favorable stability and high dissolving speed, solves the problem of low content of high solid contents of the soft capsule contents prepared from water-soluble solid materials, ensures that the content of the water-soluble solid contents in the soft capsule contents is improved to over 50 percent by weight, improves the efficacy and reduces the administration dose. Meanwhile, no emulsifying agent is added, so that the natural attribute of products can be ensured.

Description

technical field [0001] The invention relates to a dosage form reform of an osteopeptide preparation, in particular to a preparation process of an osteopeptide soft capsule. Background technique [0002] At present, the biggest shortcoming of soft capsules is: prepare soft capsules with water-soluble solids as the main ingredient, because it is difficult to dissolve in oil, so the content of water-soluble solids in the soft capsule content is difficult to improve (usually controlled at 10-30 % (wt)), and a large amount of emulsifiers need to be added to prevent the water-soluble solids from settling and delaminating, which will affect the fluidity of the soft capsule content, and then affect the compression molding of the soft capsule. And the bone peptide soft capsule of the present invention is the extract powder that is made by the water extract of Chinese medicine Rhizoma Rhizoma Rhizoma Drynariae, Curcuma longa, Radix Glycyrrhizae through spray drying, mixes with chondro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K38/02A61K47/44A61K9/48A61P3/14A61P19/08A61K31/737A61K36/9066
Inventor 马建中
Owner 四川新渔现代生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap