Chinese medicinal nose drops for treating colds and quality control method and application of preparation thereof
A technology of nasal drops and traditional Chinese medicine, applied in the field of traditional Chinese medicine, to achieve the effect of eliminating inflammation, clear mechanism, and clear antipyretic effect
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Embodiment 1
[0026] Preparation process of traditional Chinese medicine nasal drops
[0027] Prescription: Beibupleurum 50g, Houttuynia cordata 35g, licorice 15g;
[0028]Preparation method: Take Houttuynia cordata and add 80% ethanol to reflux and extract 3 times (add 20 times the amount of ethanol each time, reflux time is 30 minutes), filter, evaporate the filtrate to remove ethanol under reduced pressure, add appropriate amount of water-containing ethanol to adjust the ethanol content to 18% (v / v), and adjust the volume of the solution to be 8 times that of the medicinal material, stir evenly, let it stand for 2 days, filter, concentrate the filtrate to a thick paste, and dry it in vacuum below 80°C to obtain Houttuynia cordata extract; take licorice coarse powder , add water and decoct 3 times (add 20 times the amount of water each time, decoct for 2 hours), filter, combine the filtrates, centrifuge (15000rpm, 15min), take the supernatant and concentrate to a thick paste, and vacuum d...
Embodiment 2
[0030] Quality Control Method of Traditional Chinese Medicine Nasal Drops
[0031] (1) Qualitative identification method:
[0032] A. Take 50ml of this product, put it in a separatory funnel, extract it twice with n-butanol, 20ml each time, and place it to separate layers. Take the n-butanol solution and evaporate it to dryness under reduced pressure, add 1ml of methanol to the residue to dissolve it, and use it as the test solution; take another quercitrin reference substance, add methanol to make a reference solution containing 0.5mg per 1ml; take another Houttuynia cordata 2.5g of powder, add 40ml of methanol to reflux extraction for 30 minutes, filter, evaporate the filtrate to dryness, add 10ml of water to the residue to dissolve, extract with 10ml of n-butanol, separate the liquids; take the n-butanol liquid and evaporate to dryness under reduced pressure, add 1ml of methanol to the residue to dissolve Dissolved as the Houttuynia reference drug solution. Take 5 μl of t...
Embodiment 3
[0040] The curative effect on cold wind-heat syndrome is confirmed by clinical trials and positive drug control
[0041] The National Drug Clinical Research Base of the Affiliated Hospital of Hubei University of Traditional Chinese Medicine is the responsible unit for clinical research, and the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine and the Second Hospital of Guangdong Province of Traditional Chinese Medicine are in charge of the antiviral oral solution (batch number: 20050608) As a positive control drug, a double-simulation double-blind phase II a clinical trial observation of traditional Chinese medicine nasal drops in the treatment of cold-wind-heat syndrome (upper respiratory tract infection) was carried out. as follows:
[0042] (1) Case distribution and comparability analysis
[0043] A total of 240 patients were enrolled in the experiment, of which 11...
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