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Preparation method of PAM (Polyacrylamide) enhancement nano-hydroxyapatite biological composite coating

A technology of nano-hydroxyapatite and composite coating, applied in the direction of coating, can solve the problem of low bonding force between coating and coating, and achieve the effect of improving bonding strength and stable crystal phase of coating

Inactive Publication Date: 2010-09-29
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still problems of low bonding between the coating and the substrate, and between the coating and the coating
[0008] At present, domestic and foreign research on improving the bonding force between the surface of C / C composites and hydroxyapatite is mainly on the deposition process and the surface modification of C / C substrates, while the use of PAM to enhance the bonding strength between the coating and the substrate and the coating Internal binding strength studies have not been reported

Method used

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  • Preparation method of PAM (Polyacrylamide) enhancement nano-hydroxyapatite biological composite coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: 1) Preparation of nano-hydroxyapatite powder First, analytically pure Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix according to the molar ratio of calcium to phosphorus of 1:1.57, then add distilled water to dissolve Ca 2+ Solution A with an ion concentration of 0.04mol / L; secondly, according to Ca(NO 3 ) 2 4H 2 O:(NH 2 ) 2 HPO 4 =1:5 mass ratio, add urea powder to solution A and stir to make a mixed solution; finally, under magnetic stirring, put the generation head of the multi-frequency sonochemical generator into the above mixed solution at 100-300w Sonochemical synthesis was performed at 40°C for 1.5 hours under ultrasonic power, and then heated to 70°C for 2 hours, then the upper liquid was filtered off, and then washed with distilled water and then with absolute ethanol. Vacuum drying to obtain nano-hydroxyapatite powder; 2) take nano-hydroxyapatite powder and disperse it in analytically pure isopropanol to make a solution with a concentration...

Embodiment 2

[0018] Example 2: 1) Preparation of nano-hydroxyapatite powder First, analytically pure Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix according to the calcium-phosphorus molar ratio of 1:1.67, then add distilled water to dissolve Ca 2+ Solution A with an ion concentration of 0.08mol / L; secondly, according to Ca(NO 3 ) 2 4H 2 O:(NH 2 ) 2 HPO 4=1:6 mass ratio, add urea powder to solution A and stir to make a mixed solution; finally, under magnetic stirring, put the generation head of the multi-frequency acoustic chemical generator into the above mixed solution at 100-300w Sonochemical synthesis was performed at 40°C for 1.5 hours under ultrasonic power, and then heated to 70°C for 2 hours, then the upper liquid was filtered off, and then washed with distilled water and then with absolute ethanol. Vacuum drying to obtain nano-hydroxyapatite powder; 2) take nano-hydroxyapatite powder and disperse it in analytically pure isopropanol to make a solution with a concentration o...

Embodiment 3

[0019] Example 3: 1) Preparation of nano-hydroxyapatite powder First, analytically pure Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix according to the molar ratio of calcium to phosphorus of 1:1.77, then add distilled water to dissolve Ca 2+ Solution A with an ion concentration of 0.12mol / L; secondly, according to Ca(NO 3 ) 2 4H 2 O:(NH 2 ) 2 HPO 4 =1:7 mass ratio, add urea powder to solution A and stir to make a mixed solution; finally, under magnetic stirring, put the generation head of the multi-frequency acoustic chemical generator into the above mixed solution at 100-300w Sonochemical synthesis was performed at 40°C for 1.5 hours under ultrasonic power, and then heated to 70°C for 2 hours, then the upper liquid was filtered off, and then washed with distilled water and then with absolute ethanol. Vacuum drying to obtain nano-hydroxyapatite powder; 2) take nano-hydroxyapatite powder and disperse it in analytically pure isopropanol to make a solution with a concentr...

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Abstract

The invention relates to a preparation method of a PAM (Polyacrylamide) enhancement nano-hydroxyapatite biological composite coating, comprising the following steps of firstly, dissolving Ca(NO3)2.4H2O and (NH2)2HPO4 into distilled water and preparing mixed liquor by putting a urea powder into the distilled water and uniformly stirring; secondly, filtering upper layer liquid after treating the mixed liquor by phonochemistrical synthesis and obtaining a nano-hydroxyapatite powder by vacuum drying; thirdly, obtaining a nano-hydroxyapatite suspension by scattering the nano-hydroxyapatite powder into isopropanol; fourthly, dissolving acrylamide into water and preparing AM solution by adding sodium sulfite and ammonium persulfate; and fifthly, treating a C / C substrate by ultrasonic waves after being put into the AM solution, fixing the treated C / C substrate on a cathode of a hydrothermal electrophoresis reactor, soaking the cathode into the nano-hydroxyapatite suspension, sealing the reactor, and obtaining the PAM (Polyacrylamide) enhancement nano-hydroxyapatite biological composite coating by electrophoretic deposition-heat treatment. The invention has the advantages of compact and uniform prepared composite coating and stable coating crystalline phase, can greatly enhance the bonding strength and has the expected bonding strength of 60-100MPa.

Description

technical field [0001] The invention relates to a preparation method of a biological composite coating, in particular to a preparation method of a PAM-enhanced nano-hydroxyapatite biological composite coating. Background technique [0002] In recent years, bone repair and bone substitute materials have become one of the research hotspots in the field of biomaterials research. [0003] Hydroxyapatite (referred to as HA or HAp, its molecular formula Ca 10 (PO4) 6 (OH) 2 ) is the main component of inorganic matter in human bone tissue. It has good biocompatibility, bioactivity and bony connection. It is considered to be the most potential human implant in the repair and reconstruction of human bone tissue defects. body material. However, the brittleness of hydroxyapatite and its inability to bear loads limit its application range (Jiang Geng, Wang Binghua, Journal of Changjiang University, 2008, 5(3): 20). In view of this, the surface of medical metal (titanium alloy, stee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/30A61L27/28
Inventor 黄剑锋王文静曹丽云李颖华吴建鹏李翠艳
Owner SHAANXI UNIV OF SCI & TECH
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