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Quantum dot iodized oil dispersion and preparation method and use thereof

A technology of quantum dots and iodized oil, applied in the field of materials and biomedicine, can solve the problems of weakening effect, loss, and reduction of quantum dot concentration.

Inactive Publication Date: 2012-07-25
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the quantum dots injected into the tumor site and the toxic ions released by the quantum dots are also easily lost from the tumor site
On the one hand, as time goes by, the concentration of quantum dots in the tumor site decreases, and the effect of photodynamic therapy or photothermal therapy weakens; on the other hand, the quantum dots and toxic ions transferred to distant places bring toxic side effects to normal tissues and organs

Method used

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  • Quantum dot iodized oil dispersion and preparation method and use thereof
  • Quantum dot iodized oil dispersion and preparation method and use thereof
  • Quantum dot iodized oil dispersion and preparation method and use thereof

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Effect test

Embodiment 1

[0043] CdCI 2 Aqueous solution, fresh NaHTe aqueous solution and mercaptopropionic acid (MPA) aqueous solution were mixed (Cd: Te: MPA ≈ 1: 0.4: 5), the pH of the mixed solution was adjusted to 8.5, the mixed solution was heated to 98 °C, refluxed, nitrogen protection, when When the maximum fluorescence peak of the CdTe quantum dots moves beyond 650nm, the heating is stopped, and the water-phase synthesized CdTe quantum dots are obtained by natural cooling.

[0044] Add methanol to the CdTe quantum dot aqueous solution to precipitate the quantum dots, wash the quantum dot precipitation repeatedly with deionized water, and then freeze-dry the quantum dots to obtain black CdTe quantum dot powder.

[0045] Quantum dot dry powder was mixed with iodized oil in three ratios:

[0046] Formula (1): 5 mg quantum dot powder, 995 mg iodized oil;

[0047] Formula (2): 300 mg quantum dot powder, 700 mg iodized oil;

[0048] Formula (3): 30 mg quantum dot powder, 970 mg iodized oil.

[...

Embodiment 2

[0054] Disperse 8 mmol of cadmium oxide into 5 ml of oleic acid, then mix it with 50 ml of paraffin oil, heat at 200°C to dissolve the cadmium oxide, and obtain A solution. At the same time, add 6 mmol of Te powder to 10 ml of and mixed with 50 ml of paraffin oil, and stirred under the protection of nitrogen to dissolve the Te powder to obtain the B solution. Then, the A solution and the B solution at a temperature of about 180°C were mixed, heated and stirred at 200°C, and reacted for 3 hours, then stopped heating and cooled naturally to obtain CdTe quantum dots synthesized in an organic phase.

[0055] The reaction product was repeatedly washed with methanol, and finally the precipitate obtained by washing was dispersed in an aqueous solution, and freeze-dried to obtain a brown CdTe quantum dot powder.

[0056] Mix the dry quantum dot powder with iodized oil, in the mixed solution, 300 mg of quantum dots, 700 mg of iodized oil, ultrasonic dispersion treatment for 30 minutes....

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Abstract

The invention relates to quantum dot iodized oil dispersion and preparation method and use thereof. The dispersion comprises the following components by mass percent: 0.5-30% of quantum dot and 70-99.5% of iodized oil. The preparation method includes that water phase synthesis is adopted to synthesize quantum dot, the quantum dot is precipitated from water solution, dried and then added into iodized oil by formula ratio, and ultrasound or oscillation processing is carried out, thus obtaining the quantum dot dispersion; or organic phase synthesis is adopted to synthesize quantum dot, organic solvent is removed by washing, drying is carried out, and the quantum dot is added into iodized oil by formula ratio, the mixed solution is subject to ultrasonic dispersing processing, thus obtaining the quantum dot dispersion. The invention has the advantages that: the quantum dot is effectively combined with the iodized oil, so as to obtain solution with quantum dot stably dispersed and greatly widen the application of quantum dot being taken as medicine for treating tumour. As the iodized oil can be combined with tumour tissue for a long time, the quantum dot can be mainly remained at the tumour position, local orientation function is realized for inhibiting growth of tumour cell, thus avoiding harming normal body tissue organ.

Description

technical field [0001] The invention belongs to the field of materials and biomedicine, and relates to the application of quantum dots, in particular to an iodized oil dispersion of quantum dots and its preparation method and application, so that quantum dots can be stably dispersed in iodized oil solution, so that quantum dots And the toxic ions released by the quantum dots stay in the iodized oil solution for a long time, which is convenient for application. Background technique [0002] Quantum dots are an important fluorescent dye, and also a photodynamic therapy reagent (ie photosensitizer) and photothermotherapy reagent with important application prospects. [0003] Photodynamic therapy is a method of local treatment of diseases, especially for tumor patients who are not suitable for surgery, photodynamic therapy is a good conservative treatment method. After the quantum dots are irradiated with light, they transfer energy to oxygen to generate singlet oxygen and some...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K41/00A61K47/44A61K33/24A61K33/30A61K33/28A61K33/36A61K33/42A61K33/04A61K33/06A61P35/00
Inventor 储茂泉周厚森
Owner TONGJI UNIV
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