Compound vitamin nanoemulsion

Abstract

The invention relates to compound vitamin nanoemulsion, belonging to the pharmaceutical technical field. the preparation method of the nanoemulsion per 1000ml comprises the following steps: fully mixing 150-240g of AEO-9 or AEO-4, 200-350g of Tween-80, 80-120g of benzyl alcohol and fat-soluble active ingredients at 30-60 DEG C to obtain oil phase, then adding water to dilute, and performing constant volume process, wherein the fat-soluble active ingredients comprises 60-180 million IU of vitamin A, 18-48 million IU of vitamin D and 25-75g of vitamin E, and vitamin K3 and dihydropyridine can be further added in the product. The product is clear and transparent, the average grain diameter is less than 10nm, the product has good dispersion stability; after nanoparticlization, vitamin A, D, Eand K has high efficiency and long-term effect and can be directly absorbed and used by the small intestine without bile, the absorptivity is 100%, and the bioavailability is about 98%. The product can be used in the livestock production; and even if the livestock and poultry have hepatic diseases or fat-absorbing disorders, the absorption of fat-soluble vitamins can not be affected, thus playinga very positive significance in improving the physique of livestock and poultry with diseases and shortening the treatment period.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a compound vitamin nanoemulsion, which can be taken orally as an animal drug additive and can be used as an injection. Background technique [0002] Vitamins are essential organic compounds in the metabolism of humans and animals, and play an important role in the metabolism, growth and development of the body, and the maintenance of body health. If a certain vitamin is lacking for a long time, it will cause physiological dysfunction and a certain disease will occur. However, the body does not synthesize vitamins by itself or in lesser amounts, and needs to obtain them from food or take vitamin supplements. At present, the multi-dimensional products on the market are still dominated by solid preparations, and there is a trend towards liquid formulations: the use of solid multi-dimensional premixes to supplement vitamins for livestock and poultry usually requires mix...

AI Technical Summary

Problems solved by technology

At present, the multidimensional products on the market are still mainly solid preparations, and there is a tendency to develop into liquid dosage forms: using solid multidimensional premixes to supplement vitamins for livestock and poultry usually requires feeding with mixing materials, which is not only labor-intensive, but also prone to The problem of uneven mixing; liquid multi-dimensional can be mixed with drinks, which has the advantages of convenient use and easy absorption

However, the existing liquid multidimensional is generally two kinds of liquids, one is water-soluble compound multidimensional, and the other is fat-soluble AD oil.

Another form of the existing liquid multidimensional is the conventional emulsion, although it can overcome the defects of solid preparations to some extent, there are still the following problems: the particle size of latex particles is large, and it is easy to block drinking water The nipple of the organ creates suitable breeding conditions for pathogenic microorganisms; the product has poor stability, and the validity period is generally 12 months. During this period, the vitamin potency can be reduced to 65% of the labeled amount, and the color tends to become darker and turbid when exposed to light; the system Poor compatibility, difficult to compound with other beneficial ingredients

Images