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Biological activated carbon nano-fiber and preparation method thereof

A technology of biologically activated carbon and carbon nanofiber, which is applied in fiber treatment, fiber chemical characteristics, rayon manufacturing, etc., can solve problems such as weak interaction force, reduced biological activity of carbon fiber, and easy to dissociate and fall off. The method is simple and maintains Osteoconduction ability, effect of improving osteogenesis ability

Inactive Publication Date: 2010-06-16
BEIJING UNIV OF CHEM TECH
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Problems solved by technology

However, in the above-mentioned patents, the synthesized HA nanoparticles are used to disperse on the surface of the carbon fibers. In this way, the HA nanoparticles are easy to dissociate and fall off due to the weak interaction between the HA nanoparticles and the carbon fibers, which further leads to the biological activity of the carbon fibers. greatly reduced

Method used

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  • Biological activated carbon nano-fiber and preparation method thereof
  • Biological activated carbon nano-fiber and preparation method thereof
  • Biological activated carbon nano-fiber and preparation method thereof

Examples

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preparation example Construction

[0023] The specific implementation steps of the preparation method of the present invention are:

[0024] (a) Dissolve calcium salt and phosphate in deionized water respectively, wherein the molar concentration of calcium salt and phosphate are both 0.1 to 1.5 mol / L, and after aging for 4 to 10 days, stir mechanically, magnetically or ultrasonically Slowly add them into the organic solution of the polymer one by one to form a uniform spinning solution. The amount of calcium salt and phosphate is prepared according to the Ca / P ratio of the desired product calcium phosphate salt. The mass concentration of the polymer The amount of acid salt is prepared according to the Ca / P ratio of the desired product calcium phosphate salt, and the mass concentration of the polymer is 10-15%;

[0025] (b) Electrospinning is used to prepare polymer nanofiber membranes containing calcium salts and phosphates, wherein the inner diameter of the syringe needle is 0.5 to 1.5 mm, the applied electros...

Embodiment 1

[0030]Dissolve 2.361g of calcium nitrate tetrahydrate and 1.143mL of triethylphosphoric acid in 10mL of deionized water respectively, and slowly add them dropwise to 100mL of polyacrylonitrile / dimethylformamide with a concentration of 10wt% after aging for 1 week solution, and then under ultrasonic stirring until a homogeneous solution was formed for electrospinning. During the electrospinning process, a No. 9 injection needle with an inner diameter of 0.9 mm was selected, the applied electrostatic voltage was 15 kV, the flow rate of the spinning solution was 0.4 mL / h, the receiving distance between the metal drum and the needle was 15 cm, and the outer diameter of the drum was 15 cm. The speed is 5m / s, and after 8 hours of spinning, a nanofiber film with a certain thickness and partial parallel orientation is obtained. The resulting electrospun nanofibrous membrane was pre-oxidized at 280 °C for 1 h. Finally, the stabilized composite nanofibers were sintered in a carbonizati...

Embodiment 2

[0032] Dissolve 2.629g of calcium nitrate tetrahydrate and 1.143mL of triethylphosphoric acid in 10mL of deionized water in turn, and slowly add them dropwise to 100mL of polyacrylonitrile / dimethylformaldehyde with a concentration of 10wt.% after aging for 1 week. amide solution, and then under ultrasonic stirring until a homogeneous solution was formed for electrospinning. During the electrospinning process, a No. 9 injection needle with an inner diameter of 0.9 mm was selected, the applied electrostatic voltage was 15 kV, the flow rate of the spinning solution was 0.4 mL / h, the receiving distance between the metal drum and the needle was 15 cm, and the outer diameter of the drum was 15 cm. The speed is 5m / s, and after 8 hours of spinning, a nanofiber film with a certain thickness and partial parallel orientation is obtained. The resulting electrospun nanofibrous membrane was pre-oxidized at 280 °C for 1 h. Finally, the stabilized composite nanofibers were sintered in a carb...

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Abstract

The invention provides biological activated carbon nano-fiber and a preparation method thereof. An electrospinning process and high-temperature sintering are adopted to generate calcium phosphate nano-particles with biological activity in situ in carbon nano-fiber, wherein the diameter of the carbon nano-fiber is between 50 and 500nm; the particle size of nanometer calcium phosphate is between 10 and 100nm; and the weight percentage is between 1 and 10 percent. The method has a simple process; and the highly dispersed calcium phosphate nano-particles strengthen the bioconjugation between the carbon nano-fiber and bone tissue, and obviously improve the induced osteogenesis ability of the carbon nano-fiber.

Description

technical field [0001] The invention relates to a bioactive carbon nanofiber and a preparation method thereof, belonging to the field of preparation technology and application research of biocomposite materials. The bioactive carbon nanofiber of the present invention is suitable for hard tissue (cranium, jaw, load-bearing bone) engineering biological Scaffold materials, replacement repair materials and filling implant materials can be used in orthopedic surgery, orthopedic surgery, and dentistry. Background technique [0002] As a typical carbon-based material, carbon fiber has good biocompatibility, low irritation to human tissue, and excellent biomechanical properties and biomechanical compatibility. The elastic modulus is comparable to that of human bone hard tissue. Therefore, carbon fiber and its composite materials can be applied to biological tissue engineering scaffolds such as artificial bones, artificial teeth and artificial joints, and have huge market demand and ...

Claims

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Application Information

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IPC IPC(8): D01F9/20D01F1/10D01D5/00A61L27/12A61L27/08
Inventor 杨小平刘海洋连鹏飞方舟邓旭亮蔡晴
Owner BEIJING UNIV OF CHEM TECH
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