Nanoparticle and preparation method thereof

Abstract

The invention relates to a nanoparticle and a preparation method thereof. Poly(lactide-glycolide acid) (PLGA) is in the center to serve as a core, phospholipid surrounds the surface of the PLGA core in monolayer and distearoyl phosphatidylethanolamine-polyethyleneglycol-carboxyl (DSPE-PEG-COOH) penetrates the monolayer phospholipid to serve as the shell. The phospholipid, the DSPE-PEG-COOH and the PLGA have good biocompatibility, can entrap hydrophobic drugs and control the drugs to release slowly in the human bodies. The phospholipid surrounds the surface of the PLGA, thus ensuring that the particle can avoid immune system recognition so that the circulating half life of the particle is lengthened. The PEG shell ensures the particle to have spatial stability, static stability, long circulation and other characteristics and to be not easily agglomerated. Meanwhile, carboxyl is easily crosslinked with such ligands as antibodies, peptide, probes and the like, thus ensuring the particle to have targeting characteristic. The preparation method of the nanoparticle is simple, convenient practical and is easy to operate and popularize.

Description

【Technical field】 [0001] The invention relates to the field of drug carriers, in particular to a nanoparticle and a preparation method thereof. 【Background technique】 [0002] Two types of mainstream nanocarriers represented by polymer nanoparticles and nanoliposomes can efficiently encapsulate and transport drugs, genes, etc., and have become a research hotspot for scientists from all over the world. Polyglycolide lactide (PLGA), polylactic acid, polycaprolactone and other polymer nanoparticles have the advantages of good biocompatibility, controllable biodegradation, low toxicity of degradation products, and easy target-controlled release. It is increasingly favored, and some products have been put into the market and clinical trials. Nano-liposomes have a biomembrane structure of phospholipid bilayers, have excellent hydrophilicity, lipophilicity and natural targeting, long-term, and inclusive properties, and are non-toxic, non-immunogenic, and absorbable. Fast speed, h...

AI Technical Summary

Problems solved by technology

However, the half-life of polymer nanoparticles is short, and the introduction of hydrophilic polymer polyethylene glycol (PEG) for modification cannot be effectively solved. At the same time, the particles are easy to agglomerate, which increasingly constitutes a technical bottleneck in the development and application of polymer nanoparticles.

Nanoliposomes also have obvious defects, such as the low encapsulation efficiency of strongly hydrophobic components, and the need for multi-step preparation and purification are also problems that have not been solved.