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Carteolol hydrochloride pellets, preparation method thereof and preparation thereof

A technology of carteolol hydrochloride pellets and carteolol hydrochloride pellets is applied in the fields of coated pellets, pellet tablets and pellet capsules, and carteolol hydrochloride pellets, and achieves easy quality control, Narrow particle size distribution and increased stability

Inactive Publication Date: 2010-04-07
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are no research reports on carteolol hydrochloride pellets at home and abroad

Method used

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  • Carteolol hydrochloride pellets, preparation method thereof and preparation thereof
  • Carteolol hydrochloride pellets, preparation method thereof and preparation thereof
  • Carteolol hydrochloride pellets, preparation method thereof and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the preparation of carteolol hydrochloride pellets

[0030] prescription

[0031]

[0032] method Grind carteolol hydrochloride, microcrystalline cellulose and polyethylene glycol 6000 into fine powders with a fineness above 100 mesh; , mix evenly, add water to make a soft material, put it in an extrusion spheronizer, set the extrusion sieve to 1.0mm, the extrusion speed to 90r / min, the spheronization speed to 480r / min, and the spheronization time to 8min to make micro pellets, dried at 40°C, sieved, and collected pellets with a particle size of 20 to 24 meshes.

[0033] quality The particle size distribution range of the obtained micropills is narrow, and the yield of the micropills with a particle size of 20 to 24 meshes is 95%; 83%.

Embodiment 2

[0034] Embodiment 2, the preparation of carteolol hydrochloride pellets

[0035] prescription

[0036]

[0037] method Grind carteolol hydrochloride, microcrystalline cellulose, lactose, magnesium stearate and talc into fine powders with a fineness of more than 100 mesh; take prescribed quantities of carteolol hydrochloride, microcrystalline cellulose and lactose , magnesium stearate and talcum powder, mix evenly, add the povidone K30 ethanol solution that mass fraction is 1% and make soft material, put in extrusion spheronizer, setting extrusion sieve hole is 1.0mm, extrusion speed The spheronization speed is 100r / min, the spheronization speed is 500r / min, and the spheronization time is 6min to make pellets, dry at 35-45°C, sieve, and collect pellets with a particle size of 20-24 meshes.

[0038] quality The particle size distribution range of the obtained micropills is narrow, and the yield of the micropills with a particle size of 20 to 24 meshes is 89%; 81%.

Embodiment 3

[0039] Embodiment 3, the preparation of carteolol hydrochloride pellets

[0040] prescription

[0041]

[0042] method Carteolol hydrochloride, microcrystalline cellulose and lactose were pulverized into fine powders with a fineness of more than 100 mesh respectively; the prescribed amount of carteolol hydrochloride, microcrystalline cellulose and lactose were mixed, and the volume fraction was added to 40% ethanol is made into a soft material, put it in an extrusion spheronizer, set the extrusion sieve to 1.0mm, the extrusion speed to 110r / min, the spheronization speed to 460r / min, and the spheronization time to 5min to make pellets , dried at 45°C, sieved, and collected pellets with a particle size of 20 to 24 meshes.

[0043] quality The particle size distribution range of the obtained micropills is narrow, and the yield of the micropills with a particle size of 20 to 24 meshes is 87%; 85%.

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Abstract

The invention discloses a carteolol hydrochloride pellets, a preparation method thereof and a preparation thereof. The pellets comprise the following components in part by weight: 30 to 50 parts of carteolol, 60 to 120 parts of filler and 0 to parts of lubricant and have the advantages of high bioavailability, small local irritation, even medicament absorbing speed and the like. The preparation method adopts an extrusion spheronization method or a centrifugation granulation method, has simple operation, easy controlled quality and low cost, and is applicable to industrial production; and the prepared pellets have narrow granularity distribution range, good roundness and smooth surface, can be quickly disintegrated and dispersed in the stomach, can be further made into coated pellets, pellet tablets or pellet capsules to improve the stability of the carteolol and effectively cover the bitter taste of the carteolol, are convenient in carrying and taking, improvethe medicament compliance for patients and have wide application prospect in disease treatment fields, such as hypertension, angina, arrhythmia, cardioneurosis, infants with tetralogy of fallot and the like.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a carteolol hydrochloride pellet, a preparation method of the pellet, and coated pellets, pellet tablets and pellet capsules further prepared by using the pellet. Background technique [0002] Pellets are spherical entities with a diameter of less than 2.5mm composed of drugs and excipients. They can be made into immediate-release, sustained-release or controlled-release pellets according to different needs. They are usually packed in bags, filled in hard capsules or made into tablets. take. In recent years, the development of micropills has attracted widespread attention, and more and more varieties are on the market. Its main characteristics are: (1) The distribution area of ​​the drug on the surface of the gastrointestinal tract increases, and the therapeutic concentration can be quickly reached after taking it, which improves the bioavailability. Reduced local irritation; (2) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/48A61K9/20A61K31/4704A61K47/38A61K47/36A61P27/06A61P9/12A61P9/06A61P9/10A61P9/00
Inventor 罗永煌乔彦茹聂延君刘艳玲田朋鑫罗雷雷曙光陈君
Owner SOUTHWEST UNIV
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