Novel process for producing sodium heparin

Abstract

The invention provides a novel process for producing sodium heparin, which comprises the following steps of enzymolysis, gum exchange adsorption, resin washing, heparin eluting, alcohol precipitation,precipitation once more, dehydration drying, crushing, mixing and packaging. The process has mature flow, convenient operation, no emission of waste intestinal dregs and overproof wastewater, complete enzymolysis reaction, short reaction time of 30 hours, low production energy consumption, low reaction temperature of between 70 and 80 DEG C, heparin extracting ratio over 90 percent, high unit yield of the heparin, only need of 1,700 pieces of small intestines of pigs for each 100 million units of heparin, low production cost, increase of economic benefit over 30 percent per 100 million units,no emission of dirty intestinal dregs and overproof wastewater, and suitability for large-scale production.

Description

technical field [0001] The invention relates to a production process of heparin sodium, in particular to a new production process for extracting heparin sodium from pig small intestine mucosa by using a biological enzymatic hydrolysis low temperature method. Background technique [0002] Heparin sodium is a natural polysaccharide extracted from biological materials. It is favored by patients and doctors in clinical use. It is widely used in the prevention and treatment of various cardiovascular and cerebrovascular diseases. It has always been the most effective anticoagulant drug, especially for Arterial and venous thrombosis and blood clots have a unique curative effect. Heparin sodium is widely distributed in the intestinal mucosa, lung, and liver of mammals, especially in the small intestinal mucosa of pigs. At present, the methods of domestic production of heparin sodium are mainly salt hydrolysis and acid hydrolysis. These two methods all use the pig small intestinal m...

AI Technical Summary

Problems solved by technology

At present, the methods for producing heparin sodium in China are mainly salt hydrolysis and acid hydrolysis. These two methods all use the pig small intestinal mucosa as raw material, and undergo salt hydrolysis and enzymatic hydrolysis under alkaline conditions. Adsorption and elution with strong alkaline cation exchange resin, and ethanol precipitation in the eluent to obtain the primary raw material of heparin sodium for sale. The disadvantages are that the production cycle is 48 hours long, the reaction temperature is as high as 95-100 ° C, and the energy consumption is large. Incomplete hydrolysis, low purity, low yield, low potency, producing a large amount of waste intestinal residue and waste water, polluting the environment