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Liver, spleen specific positive magnetic nuclear resonance contrast agent and method of preparing the same

A nuclear magnetic resonance and contrast agent technology, applied in the field of medical materials, can solve problems such as affecting the accuracy of MRI diagnosis, unsatisfactory blood compatibility, poor biocompatibility, etc., and achieve good dispersion stability, good biocompatibility, The effect of high relaxation properties

Inactive Publication Date: 2009-10-07
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Superparamagnetic iron oxide contrast agents (such as iron oxide nanoparticles), because the magnetic nanoparticles have high toxicity to the human body and poor biocompatibility, people use polymers with certain biocompatibility or human serum albumin Coated to reduce its toxicity to the human body, but these contrast agents are not ideally compatible with human blood
[0006] At present, the MRI contrast agents used in domestic hospitals are basically non-specific contrast agents (such as gadolinium (Gd) chelate). Due to its non-specific shortcomings, similar signal changes can be seen in various tissues of patients after injection, resulting in image Poor contrast ratio greatly affects the diagnostic accuracy of MRI

Method used

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  • Liver, spleen specific positive magnetic nuclear resonance contrast agent and method of preparing the same
  • Liver, spleen specific positive magnetic nuclear resonance contrast agent and method of preparing the same
  • Liver, spleen specific positive magnetic nuclear resonance contrast agent and method of preparing the same

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Embodiment 1

[0032] Weigh 0.1mol Ca(NO 3 ) 2 and 0.06mol(NH 4 ) 2 HPO 4 In a beaker, add 300ml of distilled water to form a solution and stir evenly. Use a dropper to dissolve (NH 4 ) 2 HPO 4 The solution was dropped into Ca(NO 3 ) 2 solution, use NH throughout the process 4 OH adjusts the pH to keep it at 11-12. After the reaction is complete, pour it into an autoclave for hydrothermal synthesis, set the temperature at 160°C, and hold the temperature for 1 hour. After cleaning, filtering, and drying to obtain hydroxyapatite nanoparticles; HA is made into a solution of 0.01mol / L, and gadopentetate meglumine is added with a weight ratio of HA:Gd-DTPA=1:1 under magnetic stirring (according to GD-DTPA injection concentration conversion), continue stirring for 12 hours, then wash, filter, and dry to obtain HA-Gd-DTPA particles, weigh 0.1gHA-Gd-DTPA and put it into 100ml water, add dispersant PEI (per gram Add 0.001-0.05g) to HA, and ultrasonically disperse for 30min. The obtained so...

Embodiment 2

[0034] Weigh 0.1mol Ca(NO 3 ) 2 and 0.06mol(NH 4 ) 2 HPO 4 In a beaker, add 300ml of distilled water to form a solution and stir evenly. Use a dropper to dissolve (NH 4 ) 2 HPO 4 The solution was dropped into Ca(NO 3 ) 2 solution, use NH throughout the process 4OH adjusts the pH to keep it at 11-12. After the reaction is complete, pour it into an autoclave for hydrothermal synthesis, set the temperature at 160°C, and hold the temperature for 1 hour. After washing, filtering, and drying to obtain hydroxyapatite nanoparticles; HA was made into a 0.01mol / L solution, and GD-DTPA was added with a weight ratio of HA:Gd-DTPA=10:1 under magnetic stirring (according to GD-DTPA DTPA injection concentration conversion), continue to stir for 12 hours, then wash, filter, and dry to obtain HA-Gd-DTPA particles, weigh 0.1gHA-Gd-DTPA and put it into 100ml water, add dispersant PEI (per gram of HA Add 0.001-0.05g) and ultrasonically disperse for 30min. The obtained solution is scann...

Embodiment 3

[0036] Weigh 0.1mol Ca(NO 3 ) 2 and 0.06mol(NH 4 ) 2 HPO 4 In a beaker, add 300ml of distilled water to form a solution and stir evenly. Use a dropper to dissolve (NH 4 ) 2 HPO 4 The solution was dropped into Ca(NO 3 ) 2 solution, use NH throughout the process 4 OH adjusts the pH to keep it at 11-12. After the reaction is complete, pour it into an autoclave for hydrothermal synthesis, set the temperature at 160°C, and hold the temperature for 1 hour. After washing, filtering, and drying, hydroxyapatite nanoparticles were obtained; HA was made into a 0.01mol / L solution, and GD-DTPA was added with a weight ratio of HA:Gd-DTPA=20:1 under magnetic stirring (according to GD-DTPA DTPA injection concentration conversion), continue to stir for 12 hours, then wash, filter, and dry to obtain HA-Gd-DTPA particles, weigh 0.1gHA-Gd-DTPA and put it into 100ml water, add PEI (0.001 -0.05g), and ultrasonically dispersed for 30min, the obtained solution was scanned under magnetic re...

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Abstract

The present invention disclose a specific positive magnetic nuclear resonance contrast agent and method of preparing the same, the contrast agent is applying gadopentetate dimeglumine (Gd-DTPA) coating or scion grafting to 1-100 nm hydroxylapatite [Ca [10](PO [4][6](OH)[2], short as HA) particles, to obtain composite granule smaller than 1000 nm, modified by proserum, polyethylene imine (PEI), polyethyleneglycol (PEG) to get dispersion stability colloid solution. Comparing with the present technology the positive magnetic nuclear resonance contrast agent of the invention is provided with low toxicity, high stability, good biocompatibility, high sensibility, high relaxation capability and liver, spleen specificity. The contrast agent colloid solution can be used for enhancing contrast imaging of human body or non-human body liver or spleen.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a specific positive nuclear magnetic resonance contrast agent for liver and spleen and its preparation method technical background [0002] Tumor is one of the major diseases affecting human health in today's society. A research report published by the World Health Organization shows that the global cancer situation will become increasingly serious, the number of new patients will increase from the current 10 million per year to 15 million in the next 20 years, and the number of deaths from cancer will also increase from 6 million to 10 million per year , cancer has become the first cause of death, and the incidence of liver cancer ranks third among cancers. Every year in China, about 350,000 patients die of liver cancer caused by hepatitis B and cirrhosis, and the trend is increasing year by year. , especially liver cancer is one of the main targets of current scientific resear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06
CPCA61K49/1881
Inventor 黄苏萍周科朝王维李志友
Owner CENT SOUTH UNIV
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