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Method for preparing nanometer spherical polyelectrolyte brush with magnetic kernel

A polyelectrolyte brush and electrolyte monomer technology, which is applied in the field of targeted therapy and can solve problems such as difficult recycling

Inactive Publication Date: 2012-01-11
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In line with the idea of ​​saving economy during application, nanoball brushes need to be recycled and reused after use, while pure nanoball brushes are very stable in the liquid phase and are not easy to recycle. The drug or protein on the brush also needs to be transported to a specific area to play a role, so there is a need for a method to effectively collect and recycle the nanoball brush or deliver the functional nanoball brush to a given location to achieve its effect

Method used

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  • Method for preparing nanometer spherical polyelectrolyte brush with magnetic kernel
  • Method for preparing nanometer spherical polyelectrolyte brush with magnetic kernel
  • Method for preparing nanometer spherical polyelectrolyte brush with magnetic kernel

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1 Co-precipitation method prepares oil-soluble iron ferric oxide nanoparticles

[0024] 48.0g FeCl 3 ·6H 2 O and FeSO 4 ·7H 2 After O was dissolved in 100ml of deionized water, pour it into a 1000ml three-necked flask, add 300ml of deionized water, and turn on the mechanical stirring and oil bath. The temperature of the oil bath was set to 90°C, and the stirring speed was set to 300 rpm. After the oil bath is stable, add 21g of oleic acid at one time, and immediately add 120ml of ammonia water dropwise after the addition of oleic acid is completed, and the reaction solution gradually changes from red to black during the process of adding ammonia water dropwise. The co-precipitation reaction was completed after 2 hours. The black reaction solution was washed three times with deionized water and absolute ethanol under the action of strong magnetism to remove the remaining ammonia and oleic acid, and the final treatment solution was suction filtered to obtai...

Embodiment 2

[0025] Embodiment 2 Schotten-Baumann reaction prepares photoinitiator HMEM

[0026] Pour 30.0g of photoinitiator HMP into a 500ml single-necked flask, add 150ml of acetone, stir until HMP is completely dissolved, then add 10g of newly purified pyridine, continue stirring at low temperature, and then add 13.6g of methacryloyl chloride (MC ) was dissolved in 50ml of acetone, and slowly added dropwise to the reaction flask, after the dropwise addition, it was reacted at room temperature for 12 hours to obtain an orange-yellow liquid, which was filtered to remove the beige precipitate at the bottom, and pure HMEM photoinitiated by chromatographic separation agent.

Embodiment 3

[0027] Embodiment 3 miniemulsion polymerization prepares magnetic inner core

[0028] First, dissolve 0.50g of sodium dodecylsulfonate in 200g of deionized water to form a water phase, and then prepare an oil phase by mixing 0.42g of n-hexadecane, 0.30g of azobisisobutyronitrile and 10.0g of styrene The monomers were mixed and dissolved, and then 2.0 g of ferric oxide nanoparticles obtained in Example 1 were dispersed in the oil phase to obtain a magnetic fluid, and then the magnetic fluid was poured into the water phase and ultrasonically finely emulsified for 2 hours to obtain a uniform fine particle. emulsion, the mini-emulsion was stirred and reacted at 65° C. for 20 hours, and the mini-emulsion polymerization was completed.

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Abstract

The invention relates to a method for preparing a nanometer spherical polyelectrolyte brush with a magnetic kernel. The whole preparation process is completed by four steps as follows: firstly, preparing ferroferric oxide nanometer magnetic nanoparticles under an alkali condition by a coprecipitation method; secondly, dispersing the magnetic nanoparticles in a styrene monomer, and obtaining polystyrene (PS) microspheres with particle diameter of between 100 and 250 nm by miniemulsion polymerization; thirdly, adding a photoinitiator in the end stage of the miniemulsion polymerization to ensurethat the photoinitiator can be coated on the surface of the PS microspheres by chemical bonds to form a photoinitiator layer; and fourthly, adding an electrolyte monomer, and initiating polymerization by illumination of an ultraviolet lamp to obtain the nanometer spherical polyelectrolyte brush with the magnetic kernel, which has the particle diameter of between 180 and 350 nm. The nanometer spherical polyelectrolyte brush with the magnetic kernel can realize quick reclamation and recycle by a magnetic field after the nanometer spherical polyelectrolyte brush is adsorbed on a noble metal ion and subjected to wastewater treatment, and also can be used in targeted dosage treatment under the navigation of the magnetic field.

Description

technical field [0001] The present invention relates to the preparation method of polymer microsphere, specifically utilize miniemulsion polymerization and photoemulsion polymerization method to prepare nano-spherical polyelectrolyte brush with magnetic inner core, and apply it to rapid recovery and recycling after wastewater treatment, It can also be used in fields such as targeted therapy after immobilizing proteins or drugs. Background technique [0002] When the charged polymer chains are densely distributed on the surface of the substrate with one end fixed, the free ends of the polymer chains will stretch out due to volume repulsion and electrostatic repulsion, forming a structure called polyelectrolyte brush. The surface of the substrate can significantly improve its adhesion, friction and interaction with external substances by introducing polymer brushes, which has broad application prospects in many fields. [0003] In 1999, the first inventor of the present appli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F285/00C08F257/02C08F112/08C08F2/22C08F2/44
Inventor 郭旭虹陈凯敏李莉朱雁房鼎业
Owner EAST CHINA UNIV OF SCI & TECH
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