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Bacteria cellulose composite material as well as preparation method and use thereof

A technology of bacterial cellulose and composite materials, applied in medical science, prosthesis, etc., can solve the problems of limited improvement of cell adhesion and osteoinductive ability, and achieve good osteogenic inductive properties and osteoinductive ability.

Inactive Publication Date: 2009-07-15
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chalmers University in Sweden [ABodin, LAhrenstedt, HFink, H Brumer, B Risberg, P Gatenholm. Modification of nanocellulose with a xyloglucan-RGDconjugate enhances adhesion and proliferation of endothelial cells: implications for tissue engineering. Biomacromolecules. 2007, 8: 3697-374] using Glycine-arginine-glycine-aspartic acid-serine (GRGDS) pentapeptide grafted xyloglucan (XG) complexed with BC, but the cell adhesion and osteoinductive ability of BC were limited

Method used

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  • Bacteria cellulose composite material as well as preparation method and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The bacterial cellulose membrane was vacuum dried. The bacterial cellulose dry film was crushed into particles smaller than 1 mm in size with a crusher. Under argon protection, the bacterial cellulose particles were soaked in a toluene solution with a mass concentration of 5% 3-aminopropyltriethoxysilane (APTES) for 2 hours, and the bacterial cellulose particles were taken out and washed with toluene, and then vacuum Dry to obtain APTES-grafted bacterial cellulose particles. Under the protection of argon, the APTES-grafted bacterial cellulose particles were dissolved in dimethylformamide (DMF) of N-succinimide 3-maleimide propionate (SMP) at a concentration of 0.002 mol / L. After soaking in the solution for 2 hours, the bacterial cellulose particles were taken out, washed with DMF, and dried in vacuum to obtain the grafted bacterial cellulose of SMP and APTES. Under argon protection, SMP and APTES graft bacterial cellulose particles in 0.001 mol / L phosphorylated serine...

Embodiment 2

[0027] The bacterial cellulose membrane was vacuum dried. The bacterial cellulose dry film was crushed into particles smaller than 1 mm in size with a crusher. Under argon protection, the bacterial cellulose particles were soaked in a toluene solution with a mass concentration of 8% 3-aminopropyltriethoxysilane (APTES) for 3 hours, and the bacterial cellulose particles were taken out and washed with toluene, and then vacuum Dry to obtain APTES-grafted bacterial cellulose particles. Under the protection of argon, the APTES-grafted bacterial cellulose particles were dissolved in dimethylformamide (DMF) of N-succinimide 3-maleimide propionate (SMP) at a concentration of 0.005 mol / L. After soaking in the solution for 3 hours, the bacterial cellulose particles were taken out, washed with DMF, and dried in vacuum to obtain the grafted bacterial cellulose of SMP and APTES. Under argon protection, SMP and APTES graft bacterial cellulose particles in 0.002 mol / L phosphorylated threon...

Embodiment 3

[0029] The bacterial cellulose membrane was vacuum dried. The bacterial cellulose dry film was crushed into particles smaller than 1 mm in size with a crusher. Under argon protection, the bacterial cellulose particles were soaked in a toluene solution of 3-aminopropyltriethoxysilane (APTES) with a mass concentration of 3% for 5 hours, and the bacterial cellulose particles were taken out and washed with toluene, and then vacuum Dry to obtain APTES-grafted bacterial cellulose particles. Under the protection of argon, the APTES-grafted bacterial cellulose particles were dissolved in dimethylformamide (DMF) of N-succinimide 3-maleimide propionate (SMP) at a concentration of 0.001 mol / L. After soaking in the solution for 5 hours, the bacterial cellulose particles were taken out, washed with DMF, and dried in vacuum to obtain the grafted bacterial cellulose of SMP and APTES. Under argon protection, SMP and APTES grafted bacterial cellulose particles in 0.003 mol / liter phosphorylat...

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Abstract

The invention belongs to the field of biologic materials, and discloses to a bacteria cellulose composite material, as well as a preparation method and an application thereof. Polypeptide with a phosphate radical is grafted on the fiber surface of bacteria cellulose with a nanometer fiber meshwork. A phosphate radical negative ion area can attract calcium positive ions to subside in the bacteria cellulose composite material under the body fluid environment; a hydroxyapatite crystal is induced to be directly mineralized on the surface of the nanometer fiber; and a nanometer gap structure formed by the nanometer fiber network can be taken as a support frame to facilitate the adhesion, the multiplication and the differentiation of osteocytes , therefore, the bacteria cellulose composite material can be used as defective human bone filling and rehabilitating materials.

Description

technical field [0001] The invention relates to the field of biomaterials, more specifically, the invention relates to a bacterial cellulose composite material capable of promoting bone repair in a body fluid environment and a preparation method thereof. Background technique [0002] Bacterial cellulose (BC), a natural polymer secreted by bacteria, has unique physical and chemical properties such as high crystallinity, high water holding capacity, ultrafine nanofiber network, high tensile strength and elastic modulus, and has been studied It is used in artificial blood vessels, artificial skin, treatment of skin injuries, and tissue engineering scaffolds. As a bone tissue engineering scaffold, BC is simple and cheap, has high wet strength and can be formed in situ, so it has become an international medical biomaterial in recent years. research hotspots. Tufts University [A Svensson, E Nicklasson, T Harrah, B Panilaitis, D L Kaplan, M Brittberg, P Gatenholm. Bacterial cellul...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/56A61L27/20A61L27/22
Inventor 林志丹张秀菊
Owner JINAN UNIVERSITY
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