Adonis amurensis total-flavone mouth paster and preparation method thereof

A technology of oral patch and total flavonoids, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effects of convenient use, prolonged action time, and simple preparation process

Active Publication Date: 2009-06-10
HANGZHOU CONBA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] One object of the present invention is to provide a kind of oral patch of total flavonoids of calendula officinalis, which is used for the treatment of oral ulcer, and has the advantages of accurate and controllable drug content, good stability, no stimulation to mucous membrane, and protective effect on ulcer surface. Advantages; at the same time, the patch is a double-layer tablet prepared by secondary compression or spray film technology, and the drug can be released to the ulcer surface in one direction, so that the drug can be localized in the lesion

Method used

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  • Adonis amurensis total-flavone mouth paster and preparation method thereof
  • Adonis amurensis total-flavone mouth paster and preparation method thereof
  • Adonis amurensis total-flavone mouth paster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Prescription (1) Adhesive layer containing medicine:

[0049] Calendula officinalis total flavonoids extract powder 40g

[0050] Carbomer 971P 30g

[0051] Dextrin 30g

[0052] Magnesium stearate 1.5g

[0053] (2) Hydrophobic protective layer:

[0054] Ethyl cellulose 30g

[0055] Lemon yellow lake 3g

[0056] Magnesium stearate 0.5g

[0057] 1000 pieces

[0058] Preparation:

[0059] (1) Preparation of granules for drug-containing layer: After mixing the prescription amount of Calendula officinalis total flavonoids extract powder, carbomer and dextrin, use 95% ethanol solution as wetting agent, granulate, dry, Whole grains, then mix with the prescribed amount of magnesium stearate, and set aside.

[0060] (2) Preparation of the particles for the hydrophobic protective layer: After mixing the prescription amount of ethyl cellulose and lemon yellow lake, use absolute ethanol as a wetting agent, granulate, dry, and size, and then mix with the prescription amount of ethyl cell...

Embodiment 2

[0063] Prescription (1) Adhesive layer containing medicine:

[0064] Calendula officinalis total flavonoids extract powder 20g

[0065] Carbomer 934P 10g

[0066] Hypromellose (60RT25) 20g

[0067] Starch 50g

[0068] Magnesium stearate 1g

[0069] (2) Hydrophobic protective layer:

[0070] Ethyl cellulose 5g

[0071] Lemon yellow pigment 0.5g

[0072] 1000 pieces

[0073] Preparation:

[0074] (1) Preparation of the granules of the drug-containing layer: Mix the total flavonoids extract powder of Calendula officinalis, carbomer, hypromellose, and starch, and dry them into granules, mix them with magnesium stearate, and set aside .

[0075] (2) Compression: Compress the above granules into tablets with a diameter of 8 mm and a tablet weight of about 100 mg.

[0076] (3) Film spraying: Dissolve ethyl cellulose and yellow pigment in 100 ml of 95% ethanol solution and spray the film.

Embodiment 3

[0078] Prescription (1) Adhesive layer containing medicine

[0079] Calendula officinalis total flavonoids extract powder 30g

[0080] Carbomer 974P 25g

[0081] Sodium Carboxymethyl Cellulose (FH6 Extra High Type) 10g

[0082] Microcrystalline cellulose 35g

[0083] Magnesium stearate 0.5g

[0084] (2) Hydrophobic protective layer

[0085] Ethyl cellulose 25g

[0086] Lemon yellow lake 2g

[0087] Magnesium stearate 2.5g

[0088] Preparation:

[0089] (1) Preparation of the granules of the drug-containing layer: Mix the total flavonoids extract powder of Calendula officinalis, carbomer, sodium carboxymethyl cellulose, and microcrystalline cellulose, use water as a wetting agent, and granulate in a fluidized bed. Then mix with magnesium stearate.

[0090] (2) Mix ethyl cellulose, lemon yellow lake, and magnesium stearate, and set aside.

[0091] (3) Press the above two groups of materials into double-layer tablets.

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Abstract

The invention relates to a herba adonidis total flavonoids oral paster and preparation method thereof. The oral paster includes two layers, one is a medicine containing adhering layer, the other is a hydrophobic protecting layer; the medicine containing adhering layer contains 100-50mg of herba adonidis total flavonoids extract directly touched with the oral mucosa surface, while the hydrophobic protecting layer faces the oral cavity. The medicine is make to be released only to the ulcerative surface direction, and positioned on the focus region; consequently, the effect time is prolonged, the problem of saliva dilution to the medicine and low bioavailability are solved; while, the effective constituents are absorbed by the mucosa, liver first pass effect of the medicine is avoided, and the bioavailability is increased; additionally, the paster is applied directly on the ulcerative surface, can protect the ulcerative surface and promotes ulceration to cure. The herba adonidis total flavonoids oral paster in the invention can be used for treating ulcerations of the oral cavity in clinic.

Description

Technical field: [0001] The invention relates to a preparation of total flavonoids of Calendula officinalis, in particular to an oral patch of total flavonoids of Calendula officinalis, which is used for treating oral ulcers. [0002] The invention also relates to a method for preparing the oral patch of total flavonoids of calendula officinalis. Background technique: [0003] Calendula officinalis is the dry flower of the malvaceae plant Abelmoschus esculentus, which is widely used in folk. In ancient my country, there is a record of using side calendula to treat oral ulcers, "Zhizhifang": "Children with aphthous sores, burn it and apply it at the end". Modern pharmacological research results show that the ethanol extract of Calendula officinalis (containing total flavonoids) has obvious anti-inflammatory, antibacterial, analgesic and other pharmacological effects. This pharmacological action confirms the feasibility of folk use for the treatment of aphthous ulcers. We screened ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K47/32A61K47/36A61K47/38A61P1/02A61K133/00
Inventor 凌沛学张玲张建强尚立霞曲延伟张新房吴永霞史国玉刘妍妍
Owner HANGZHOU CONBA PHARMA
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