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Medicine composition for treating mouth, throat disease and preparation method thereof

A throat disease and composition technology, applied in the field of medicine, can solve the problems of inaccurate bactericidal/bacteriostatic effect, inability to quickly relieve pain, influence wound healing, etc., and achieve a simple and feasible preparation process, low toxicity, and fast onset of action. Effect

Active Publication Date: 2009-04-01
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is aimed at the treatment of various diseases such as oral cavity and throat, especially the shortcomings of existing drugs for the treatment of oral ulcers, such as inaccurate bactericidal / bacteriostatic effect, thus affecting curative effect and narrow application range; or Because the prescription does not contain analgesic ingredients, it cannot relieve pain quickly, or does not contain anti-inflammatory ingredients that affect wound healing, etc., providing a new innovation of local sterilization, anti-inflammation, and analgesia for the treatment of oral and throat diseases. sexual compound

Method used

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  • Medicine composition for treating mouth, throat disease and preparation method thereof
  • Medicine composition for treating mouth, throat disease and preparation method thereof
  • Medicine composition for treating mouth, throat disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: buccal tablet

[0025] 1. Prescription:

[0026] Prescription ingredients 1000 tablets dosage (g)

[0027] Cediiodine 11.5

[0028] Lidocaine 1.0

[0029] Menthol 2.0

[0030] Lactose 300.0

[0031] Mannitol 50.0

[0032] Xylitol 50.0

[0033] PVPK30 8.0

[0034] Magnesium Stearate 1.5

[0035] 70% ethanol Q.S.

[0036] 2. Preparation process: The cediodine used in the prescription is the HP-β-CD inclusion compound of iodine. Dissolve the prescribed amount of menthol in 10ml of absolute ethanol, and spray evenly in lactose that has passed 80 mesh, dry at 60°C and pass through a 80 mesh sieve. Take main ingredient and adjuvant by prescription quantity, all pass 80 mesh sieves. Mix the other raw and auxiliary materials except magnesium stearate evenly by the method of equal increase, use 70% ethanol to make soft material, granulate with a 20-mesh sieve, dry at 60°C for about 20 minutes, and then granulate with a 18-mesh sieve . Add magnesium ste...

Embodiment 2

[0037] Embodiment 2: buccal tablet

[0038] 1. Prescription:

[0039] Prescription ingredients 1000 tablets dosage (g)

[0040] Cediiodine 10.5

[0041] Dyclonine Hydrochloride 0.5

[0042] Menthol 5.8

[0043] Lactose 200.0

[0044] Mannitol 200.0

[0045] Malic acid 2.0

[0046] Magnesium stearate 4.5

[0047] 3% hypromellose in water Q.S.

[0048] 2. Preparation process: The cediodine used in the prescription is the HP-β-CD inclusion compound of iodine. Dissolve the prescribed amount of menthol in 5ml of absolute ethanol, and spray evenly in lactose powder that has passed 80 mesh, dry at 60°C and pass through a 80 mesh sieve. Take main ingredient and adjuvant by prescription quantity, all pass 80 mesh sieves. Mix the other raw and auxiliary materials except magnesium stearate and malic acid according to the method of equal increase, make soft material with 3% hypromellose solution, granulate with 20 mesh sieve, dry at 60°C, 18 mesh Sieve whole grains. Add magnes...

Embodiment 3

[0049] Embodiment 3: buccal tablet

[0050] 1. Prescription:

[0051] Prescription ingredients 1000 tablets dosage (g)

[0052] Cediiodine 9.5

[0053] Tetracaine Hydrochloride 2.0

[0054] Simenthol 10.5

[0055] Lactose 150.0

[0056] Mannitol 50.0

[0057] Sucrose 200.0

[0058] Malic acid 1.0

[0059] Magnesium stearate 3.5

[0060] PVPK30 ethanol solution Q.S.

[0061] 2. Preparation process: the cedi iodine used in the prescription is the α-CD inclusion compound of iodine, and the cedimenthol is the β-CD inclusion compound of menthol. Take main ingredient and adjuvant by prescription quantity, all pass 80 mesh sieves. Mix other raw and auxiliary materials except magnesium stearate according to the method of equal increase, and use PVP K30 Soft material made from ethanol solution, granulated with 20-mesh sieve, dried at 60°C, granulated with 18-mesh sieve. Add magnesium stearate to the prepared granules, mix evenly and press into tablets to obtain.

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Abstract

The invention relates to a medical combination for remedying oral and throat diseases and belongs to the pharmacy field. A medical combination for remedying the oral and throat diseases consists of active components and medically acceptable auxiliary material. The active components are cydiodine and novocain, and the weight portion ratio of the cydiodine and the novocain is 5-13 to 0.5-2. Or the active components are the cydiodine, the novocain and anti-inflammatory drug, the weight portion ratio of the cydiodine, the novocain and the anti-inflammatory drug is 5-13 to 0.5-2 to 0.1-0.5, and the weight percentage of the active components is 1 percent to 35 percent. The medical combination has the advantages that the invention selects the cydiodine as bactericide which has efficient effect on killing various microorganisms and does not produce drug resistant strain; and the medical combination integrates three effects of sterilizing, resisting inflammation and alleviating pain as a whole and can effectively promote the elimination of the symptoms of the oral and throat diseases and the concrescence of wound surface. The medical combination also is characterized by no irritation on mucosa, simple preparation technology, stable performance and fit for the industrialized production.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diseases of the oral cavity and throat, more specifically a compound pharmaceutical composition containing one or two of cediodine, local anesthetics and anti-inflammatory drugs and a preparation method thereof. The invention relates to treating oral cavity and throat diseases, in particular to a buccal tablet for mainly treating oral ulcers, which belongs to the field of medicine. Background technique [0002] Various oral ulcers, periodontal inflammation, acute and chronic pharyngitis, and tonsillitis are all common and frequently-occurring diseases of the oral cavity and pharynx. These diseases affect people's work, study and physical and mental health to varying degrees. Some due to untimely or incomplete treatment can induce other diseases, such as bacteremia, sepsis, pulmonary infection, myocarditis and pericarditis, etc., and severe cases can be life-threatening. [0003] Oral ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K45/06A61K9/12A61K9/20A61K9/70A61K47/40A61P1/02A61P11/04A61K31/167A61K31/245A61K31/445A61K31/46A61K31/57A61K31/573
Inventor 高永良曲昌海李劲彤
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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