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Preparation method of dental composite resin containing function monomer PMDM and modified hydroxylapatite and use thereof

A technology of hydroxyapatite and functional monomers, applied in dental preparations, dentistry, medical science, etc., can solve the problems of products with excellent comprehensive performance, edge micro-leakage, etc., achieve excellent curing performance, improve interface strength, and improve the preparation process simple effect

Inactive Publication Date: 2009-03-25
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional restorative resins have no adhesiveness, and when they are filled into the tooth for restoration, if no adhesive is assisted, marginal microleakage will easily occur
Therefore, the research and development of cheap and efficient dental composite resins has important clinical significance. However, at present, there are relatively few cheap dental composite resins with independent intellectual property rights in China. Most of the clinically used dental composite resins are imported dental composite resins. There are few products, but each has its own advantages and disadvantages. There is no product with excellent comprehensive performance.

Method used

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  • Preparation method of dental composite resin containing function monomer PMDM and modified hydroxylapatite and use thereof
  • Preparation method of dental composite resin containing function monomer PMDM and modified hydroxylapatite and use thereof
  • Preparation method of dental composite resin containing function monomer PMDM and modified hydroxylapatite and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Add 3g of hydroxyapatite (HPA) into the organic solvent, and then add 0.03g of the polymerization inhibitor methoxyphenol and 0.15g of the catalyst sulfuric acid, and then place it in a constant temperature oven, and make the polymerization inhibitor and the catalyst at 40°C Dissolve, add 5g of methacrylic acid, reflux reaction at 60°C for 2 hours, filter the obtained product while it is hot, extract the filter cake with chloroform for 12 hours, wash with distilled water, dry, and obtain modified hydroxyapatite (HPA- unsaturated). Such as figure 1 Shown are the particle size distribution plots of modified and unmodified hydroxyapatite.

[0043] Add 3% functional monomer PMDM in mass parts to the matrix resin Bis-GMA, stir evenly, add 0.01g photosensitizer CQ and 0.01g organic amine activator DMAEMA, stir evenly, add 8g micron-level and 2g nano-level modification respectively hydroxyapatite, diluted with 1.7g of ethanol solvent, placed in a vacuum oven at 40°C for 2 ho...

Embodiment 2

[0046]Add 4g of hydroxyapatite (HPA) to the organic solvent, and then add 0.06g of inhibitor hydroquinone and 0.28g of catalyst p-toluenesulfonic acid in sequence, place it in a constant temperature oven, and make the polymerization inhibitor at a temperature of 50°C. Dissolve the agent and the catalyst, add 8g methyl methacrylate, reflux at 65°C for 2.5 hours, filter the resulting product while it is hot, extract the filter cake with benzene for 15 hours, wash it with distilled water, and dry it to obtain the modified hydroxyphosphorus Greystone (HPA-unsaturated).

[0047] Add 7% functional monomer PMDM in mass parts to the matrix resin Bis-GMA, stir evenly, add 0.05g photosensitizer CQ and 0.05g organic amine activator DMAEMA, stir evenly, add 14g micron-level and 6g nano-level modification respectively hydroxyapatite, diluted with 2.5g of acetone solvent, placed in a vacuum oven, placed at 45°C for 2.5 hours, until the solvent evaporated and the air bubbles were eliminated,...

Embodiment 3

[0050] Add 5g of hydroxyapatite (HPA) into the organic solvent, and then add 0.08g of polymerization inhibitor phenothiazine and 0.45g of catalyst sodium methoxide in sequence, place in a constant temperature oven, and make the polymerization inhibitor and catalyst Dissolve, add 10g of acrylic acid, reflux at 70°C for 2.5 hours, filter the obtained product while it is hot, extract the filter cake with toluene for 25 hours, wash with distilled water, and dry to obtain modified hydroxyapatite (HPA-unsaturated) .

[0051] Add 10% of the functional monomer PMDM in mass parts to the matrix resin Bis-GMA, stir evenly, add 0.10g of photosensitizer CQ and 0.10g of organic amine activator DMAEMA, stir evenly, add 12g of micron-level and 8g of nano-level modification respectively hydroxyapatite, diluted with 2.0g ether solvent and placed in a vacuum oven at 50°C for 2.5 hours, until the solvent evaporated and air bubbles were eliminated to obtain a dental composite resin.

[0052] Use ...

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Abstract

The invention belongs to the biomedical high molecular material technical field, in particular to a preparation method and the application of dental composite resin which contains functional monomer PMDM and modified hydroxyapatite. The preparation method includes the steps: 5%-20% of functional monomer PMDM is added to the substrate resin and placed in a constant-temperature oven; under the temperature of 40 DEG C -80 DEG C, the PMDM is dissolved in the substrate resin and stirred evenly; then photosensitizer and organic amine activator are added to the substrate resin and stirred evenly; then modified inorganic filler is added and diluted in solvent; the amount of solvent is 5%-10% of the mass of the mixture; the mass fraction of inorganic filler is 20%-70% of the total mass; inorganic filler is stirred evenly; the mixture is placed in a vacuum oven and placed under 40 DEG C-80 DEG C for 2-4 hours; the composite resin paste is obtained after the solvent is volatilized completely and the air bubbles are eliminated. The oral cavity repair resin has the advantages of good bond performance, ultrastructure, higher mechanical intensity, higher biocompatibility, having wide application prospect in the oral cavity repair field, having reasonable preparation line, obtainable raw materials, lower price, simple preparation process, having important popularization and application values.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a preparation method and application of a dental composite resin containing functional monomer PMDM and modified hydroxyapatite. Background technique [0002] In the late 1980s, authoritative journals optimistically predicted that dental caries could be brought under control and might become another disease to be eradicated. However, the World Health Organization's survey on the epidemic does not support this assertion. The statistical results show that the prevalence of dental caries remains high in some underdeveloped countries. At present, the per capita caries rate in our country is 40%, among which the caries rate of children is 80%, that of young people is 60-70%, and that of the elderly is 52%. Each patient involves an average of 2-3 teeth. , the prevalence of gingivitis and periodontitis is also 70%. The large demand for oral and dental ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/083
Inventor 许乾慰张黎王国建
Owner TONGJI UNIV
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