Medicament compound for treating chronic gastritis and preparation method thereof

A chronic gastritis and drug technology, applied in the field of medicine, can solve the problems of single action target, inability to completely cure chronic gastritis, side effects, etc., and achieve the effect of small dosage, small side effects and good curative effect

Inactive Publication Date: 2009-01-21
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the drugs for the treatment of chronic gastritis are western medicines. Most of these drugs (such as proton pump inhibitors, histamine H2 receptor antagonists, and selective M1 choline receptor antagonists) start from inhibiting the formation of gastric acid. Quickly relieve symptoms such as stomach acid, bloating, and stomach pain, but long-term use is prone to side effects, and these drugs have a single target, so most of them cannot completely cure chronic gastritis

Method used

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  • Medicament compound for treating chronic gastritis and preparation method thereof
  • Medicament compound for treating chronic gastritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 group: preparation of compound extract

[0017] (1) Take 700g of Codonopsis pilosula, 100g of fried Atractylodes macrocephala, 700g of poria cocos, 100g of licorice, 200g of angelica, 500g of Magnolia officinalis, 500g of pinellia, 500g of tangerine peel, 200g of amomum, 200g of Yanhu, 600g of astragalus, 800g of citrus aurantium, 400g of yellow lotus, 100 g of Panax notoginseng was pulverized and mixed, extracted three times with 6 times the amount of water (34 L) to obtain the water extract, concentrated to a density of 1.1-1.2, and then spray-dried to obtain a total of 1400 g of F1 powder, with a yield of 25%.

[0018] (2) Take Codonopsis 700g, fried Atractylodes macrocephala 200g, Poria cocos 800g, licorice 200g, angelica 300g, Magnolia officinalis 600g, pinellia 600g, tangerine peel 600g, amomum 300g, Yanhu 300g, astragalus 700g, citrus aurantium 900g, yellow lotus 500g, 100 g of Panax notoginseng was pulverized and mixed, extracted three times with 6 tim...

Embodiment 2

[0020] Embodiment 2 groups: the preparation of active extract

[0021] (1) Take 700g of Codonopsis pilosula, 200g of fried Atractylodes macrocephala, 300g of angelica, 600g of tangerine peel, 300g of amomum, and 900g of citrus aurantium, mix them after pulverization, put in water steam for distillation and extraction for 6 hours, and collect a total of 39g of oily matter obtained from distillation, that is, active extract A, Yield 1.3%.

[0022] (2) Take 800g of Poria cocos and 200g of licorice, mix them after pulverization, and reflux extract with 6 times the amount of 95% ethanol aqueous solution (6L) for three times, take the extract, recover ethanol, concentrate to a density of 1.1-1.2, and spray dry to obtain powdery active A total of 120 g of extract B was obtained, with a yield of 12%.

[0023] (3) Take Magnolia officinalis 600g, Pinellia 600g, Yanhu 300g, Astragalus membranaceus 700g, Huanglian 500g, Panax notoginseng 100g, grind them and mix them with the medicinal m...

Embodiment 3

[0024] Embodiment 3 groups: the preparation of active extract composition

[0025] 7.8 g of active extract A prepared in Example 1 was clathrated with 54.6 g of β-cyclodextrin by grinding method, and the resulting clathrate was thoroughly mixed with 24 g of active extract B and 47.6 g of active extract C to obtain an active extract composition D a total of 130g.

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Abstract

The invention discloses a medicine for treating chronic gastritis and a preparation method thereof, wherein, the medicine has the ingredients of 7 parts of dangshen, 1-3 parts of parched white atractylodes rhizome, 7-9 parts of tuckahoe, 1-3 parts of liquorice, 2-4 parts of angelica, 5-7 parts of magnolia officinalis, 5-7 parts of pinellia tuberifera, 5-7 parts of dried tangerine peel, 2-4 parts of amomum villosum, 2-4 parts of rhizoma corydalis, 6-8 parts of radix astragali, 8-10 parts of bitter orange, 4-6 parts of goldthread root and 1-3 parts of sanchi; the preparation method is that: (1) the medicine materials are directly ground into powder and prepared into oral preparation according to the conventional pharmacy technique; or (2) the raw material and water are mixed together and decocted so as to prepare the oral preparation by taking the aqueous extract; or (3) the raw material medicine is extracted and purified by a certain method to obtain the composite of active extract, and the oral preparation is prepared according to the conventional pharmacy technique.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound Chinese patent medicine for treating chronic gastritis prepared from traditional Chinese medicines. Background technique [0002] Chronic gastritis is chronic inflammation of the gastric mucosa and is also a common disease, the incidence of which increases with age. At present, most of the drugs for the treatment of chronic gastritis are western medicines. Most of these drugs (such as proton pump inhibitors, histamine H2 receptor antagonists, and selective M1 choline receptor antagonists) start from inhibiting the formation of gastric acid. Quickly relieve symptoms such as stomach acid, bloating, and stomach pain, but long-term use is prone to side effects, and these drugs have a single target, so most of them cannot completely cure chronic gastritis. Therefore, the research on traditional Chinese medicine and natural medicine for the treatment of chronic gastritis has been st...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K9/14A61K9/20A61K9/48A61P1/04
Inventor 杨中铎李涛马建忠王鸣刚
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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