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Polycaprolactone/polyethyleneglycol tissue engineering bracket material and preparation method thereof

A tissue engineering scaffold, polyethylene glycol technology, used in medical science, prosthesis, bone implants, etc., can solve the problem of no similar or similar patent reports, and achieve good mechanical properties, high porosity, and pore size. adjustable effects

Inactive Publication Date: 2008-10-22
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no domestic patent report on the use of polycaprolactone and polyethylene glycol blends to prepare three-dimensional porous scaffold materials for tissue engineering
However, using polycaprolactone and polyethylene glycol as raw materials, the method of preparing tissue engineering scaffold materials through electrospinning technology and fiber fusion method has no similar or similar patent reports at home and abroad.

Method used

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  • Polycaprolactone/polyethyleneglycol tissue engineering bracket material and preparation method thereof
  • Polycaprolactone/polyethyleneglycol tissue engineering bracket material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Using tetrahydrofuran as a co-solvent, polymer PCL with a molecular weight of 50,000 and a melting point of 58-60°C, and a polymer PEG with an average molecular weight of 1000 and a melting point of 50-54°C in a ratio of 80:20 Dissolve in a co-solvent, stir evenly to make a transparent uniform solution, electrospun to make an electrospun fiber mat, dry it in a vacuum oven, remove the residual solvent, take it out, layer it, and fill it in a mold with a specific shape. The temperature of the vacuum oven was set to 56°C, the mold was placed in the vacuum oven at a constant temperature for 20 minutes, and then taken out. After cooling, the mold was demolded and sterilized by ultraviolet to obtain a tissue engineering scaffold material with a specific shape and good performance. The diameter of the fiber felt measured by scanning electron microscope and Photoshop software is 800±100nm, and the contact angle test shows that the hydrophilicity of the material surface is improved,...

Embodiment 2

[0029] Using a mixed solvent of tetrahydrofuran and ethanol as a co-solvent, a polymer PCL with a molecular weight of 100,000 and a melting point of 58-60°C, and a polymer PEG with an average molecular weight of 2000 and a melting point of 50-54°C at a ratio of 70:30 Dissolve it in a co-solvent, stir it evenly, make a transparent solution, electrospun to make an electrospun fiber mat, dry it in a vacuum oven, take it out, layer it and fill it in a mold with a specific shape, set the vacuum oven temperature The temperature is set at 54°C, the mold is placed in a vacuum oven at a constant temperature for 15 minutes, and then taken out. After cooling, the mold is demolded to obtain a tissue engineering scaffold material with a specific shape and good performance. The diameter of the fiber felt measured by scanning electron microscope and Photoshop software is 300±100nm. The contact angle test shows that the hydrophilicity of the material surface is improved, which preliminarily prove...

Embodiment 3

[0031] Using a mixed solvent of chloroform and methanol as a co-solvent, the polymer PCL with a molecular weight of 1 million and a melting point of 58-60°C, and a polymer PEG with a molecular weight of 2000 and a melting point of 50-54°C in a ratio of 50:50 Dissolve in a co-solvent, stir evenly, make a transparent solution, electrospun to make an electrospun fiber mat, dry it in a vacuum oven, remove the residual solvent, take it out, layer it, and fill it in a mold with a specific shape. The temperature of the vacuum oven is set to 50°C, and the mold is placed in the vacuum oven at a constant temperature for 5 minutes and then taken out. After cooling, the mold is demolded to obtain a tissue engineering scaffold material with a specific shape and good performance. The diameter of the fiber mat measured by scanning electron microscope and Photoshop software is 600±100nm, and the contact angle test shows that the hydrophilicity of the material surface is improved, which preliminar...

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Abstract

The invention relates to a polycaprolactone / polyethyleneglycol tissue engineering stent material and a preparation method thereof. The components of the material include: polycaprolactone and polyethylenelycol with the proportion of 100 to 0 to 40 to 60. The preparation method includes: (1) the polycaprolactone and the polyethylenelycol with a certain proportion are dissolved in cosolvent to obtain uniform transparent solution; (2) the solution is spun into a fiber felt of nano / secondary micron grade by the technique of electrostatic spinning; (3) a vacuum oven is vacuumed to remove the residual solvent of the fiber felt; (4) the fiber felt is took out, and is overlapped and filled in the mold with a specific shape; (5) the mold is put in the vacuum oven and is took out to be cooled for the UV sterilization after being heated at the constant temperature near the blend melting temperature. The stent material system of the invention has the advantages of stable structure, uniform structure of internal holes and is mutually communicated with holes and can be used as a cartilage tissue engineering cell stent.

Description

Technical field [0001] The invention belongs to the field of biological tissue engineering carrier materials, and particularly relates to a tissue engineering three-dimensional porous scaffold material prepared with polycaprolactone and polyethylene glycol as raw materials and a preparation method thereof. Background technique [0002] The loss or dysfunction of tissues and organs seriously affects human health, leading to human disease and death. Although traditional autologous transplantation, allogeneic transplantation, and artificial substitutes have shown good therapeutic effects, their defects such as immune rejection, limited donor sources, or the need for secondary surgery restrict their application, and the development of tissue engineering makes up for it. These defects. Tissue engineering collects functionally-related living cells, plant them on natural or synthetic three-dimensional scaffolds with a certain spatial structure, culture them in vitro, and transplant cell...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61F2/28
Inventor 杨庆彭兰兰郯志清沈新元陈思诗
Owner DONGHUA UNIV
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