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Novel medical hot melt resin carrier gel matrix and its preparation method and application

A resin carrier and hot-melt technology, applied in the field of medicine, can solve problems such as environmental pollution, difficult performance adjustment, poor skin adhesion, etc., and achieve the effects of simple formulation and preparation process, unique molding processing ability, and stable matrix properties.

Active Publication Date: 2008-10-22
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, a large amount of organic solvents are used in the production process of rubber paste, which brings unsafe factors to production and easily pollutes the environment
During pulping and filtration, the improper storage of zinc oxide particles often absorbs water or the water in the solvent gasoline tank is brought into the tank, making it difficult to filter and difficult to clean mechanical equipment.
Therefore, plasters based on natural rubber are rarely seen in the international market at present due to complex processes, skin irritation, and serious allergies, and their application prospects are bleak.
[0004] Babu plaster in the plaster is a new dosage form for transdermal administration, but due to the complex composition of the matrix excipients, performance adjustment (especially structural adjustment) is difficult, there are dehydration aging, poor adhesion to the skin after long-term application, etc. problem; moreover, it is necessary to add a variety of other adhesives, cross-linking agents and other additives when it is compatible with the drug, and a large number of composition adjustment experiments are required, and it is not easy to adjust the performance after mixing, and the patch production is poor in adjustability. Equipment production of cataplasms
Therefore, the development of this dosage form is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] In the reactor, add 40 parts of styrene-isoprene-styrene block copolymers (in parts by weight, the same below), 20 parts of liquid paraffin, 5 parts of rosin glycerides, 5 parts of lithopone, nitrogen 2 parts of ketone were heated to 120° C., then mixed and stirred under vacuum for 30 minutes, and the novel medical hot-melt resin carrier gel matrix of the present invention was prepared.

[0035] Heat the medical hot-melt resin carrier gel base to 115°C, add the Xiaotong Plaster extract made from the prescription of Qizheng Xiaotong Plaster with 0.05 times the mass of the hot-melt resin carrier gel base, and stir for 50 minutes to obtain Xiaotong Plaster The resin plaster is then applied, peritoneal, and cut to obtain the finished resin plaster.

Embodiment 2

[0037] In the reactor, add 60 parts of styrene-butadiene-styrene block copolymers successively, vaseline 20, C 5 15 parts of petroleum resin, 5 parts of lithopone, and 2 parts of azone were heated to 240° C., and then vacuumized and mixed for 90 minutes to prepare the new medical hot-melt resin carrier gel matrix of the present invention.

[0038] Heat the medical hot-melt resin carrier gel matrix to 75°C, add 0.1 times the mass of the hot-melt resin carrier gel base, and prepare the Shangshizhipain ointment extract made according to the prescription of Shangshizhipain ointment in "Chinese Pharmacopoeia", and stir for 30 minutes to prepare Shangshi Pain Relief Ointment resin plaster, then spread, peritoneal, and cut to get the finished resin plaster.

Embodiment 3

[0040] Add 70 parts of styrene-butadiene-styrene radial block copolymer, 40 parts of liquid paraffin, 30 parts of rosin glyceride, 2 parts of lithopone, and 7 parts of azone into the reaction kettle and heat to 80°C. Then vacuumize and mix and stir for 60 minutes to prepare the novel medical hot-melt resin carrier gel matrix of the present invention.

[0041] Heat the medical hot-melt resin carrier gel base to 95°C, add safflower superfine powder 0.5 times the mass of the hot-melt resin carrier gel base, stir for 45 minutes to prepare a Chinese medicine superfine powder resin plaster, and then apply, peritoneal, and cut That is, the finished resin paste is obtained.

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PUM

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Abstract

The invention provides a novel medicinal thermal melting resin vector adhesive matrix which is made from a thermoplastic elastomer, medical resin, softerner, skin transdermal enhancer and excipient which are mixed in a way of melting according to a certain percentage. The novel medicinal thermal melting resin adhesive prepared by the invention is a substitute for traditional black plaster, adhesive plasters, cataplasm and attached agent matrix excipient. The novel medicinal thermal melting resin vector adhesive matrix of the invention achieves the requirement of new medicinal excipient declared by SFDA in aspects of preparation process, production equipment, drug standard, pilot-scale study, drug stability, experimental storage, etc. Emplastrum as the matrix which is produced by the novel medicinal thermal melting resin vector adhesive of the invention has the characteristics of large drug loading, fast drug releasing rate, high stability, small skin irritation, short production cycle, high efficiency, safety, environmental protection, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a matrix (auxiliary material) for preparing an external transdermal drug delivery plaster, in particular to a matrix of a novel medical hot-melt resin carrier glue. The invention also relates to the novel medical hot-melt resin The preparation process of the matrix of the resin carrier gel and its application in the production of plasters. Background technique [0002] The transdermal drug delivery system is a drug dosage form that uses the skin as a drug delivery channel. It can release drugs into the body circulation at a constant rate through the skin for a long time, avoid drug decomposition in the digestive tract, reduce damage to the stomach and liver, and is easy to use and The advantages of taking medicine and stopping medicine at any time have become one of the development directions of modern pharmaceutical preparations. [0003] The rubber ointment in the plaster, as o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44A61K47/32A61K9/70
Inventor 雷菊芳朱永红姜学军
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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