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Preparation of gel injection molding of porous titanium-cobalt alloy medical implant article

A technology for gel injection molding and implants, which is used in the field of gel injection molding to prepare porous medical implants with excellent biocompatibility and complex shapes, and can solve the problem of difficulty in controlling the size of bubbles, high cost of small-scale production, and porosity. It can achieve the effects of excellent biocompatibility and tissue binding, lower production costs and complex shapes.

Inactive Publication Date: 2008-10-08
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the production process of porous metal materials prepared by powder metallurgy pressing is simple, low in cost, and can obtain porous metal materials with uniform structure, but the porosity is low, and it is difficult to meet the requirements of complex shapes of medical implants, and the mold cost is relatively high. High, small-scale production costs are high; slurry foaming method can obtain higher porosity, the disadvantage is that it is difficult to control the size of the bubbles, so it is difficult to obtain porous materials with uniform pore size distribution, and it is difficult to obtain complex shapes

Method used

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  • Preparation of gel injection molding of porous titanium-cobalt alloy medical implant article

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Weigh 1920g of titanium powder and 80g of cobalt powder, and mix them in a planetary ball mill for 2 hours;

[0029] 2. Dissolve 159.7g monomeric acrylamide and 0.13g cross-linking agent N,N′-methylenebisacrylamide in 807ml deionized water, add the mixed powder in 1, and stir evenly;

[0030] 3. Measure 4.35ml of dispersant oleic acid and add it to the 2 solution, stir evenly to make a slurry;

[0031] 4. Put the 3 slurry into a high vacuum environment to exhaust for 15 minutes;

[0032] 5. Apply a thin layer of release agent isooctyl alcohol on the inner wall of the mold; measure 4ml of catalyst N, N, N', N'-tetramethylethylenediamine and 4ml of initiator ammonium persulfate (to ensure enough injection molding time), add in 4 slurry, stir evenly;

[0033] 6. After the grouting is completed, put it in a vacuum drying oven with a constant temperature of 60°C to dry;

[0034] 7. After drying for 30 minutes, remove the mold, trim the blank, and then put it in a vacuu...

Embodiment 2

[0037] 1. Weigh 1600g of titanium powder and 50g of cobalt powder, and mix them in a planetary ball mill for 2 hours;

[0038] 2. Dissolve 135g of monomeric acrylamide and 0.1g of cross-linking agent N,N'-methylenebisacrylamide in 750ml of deionized water, add the mixed powder in 1, and stir evenly;

[0039] 3. Take 3.5ml of dispersant oleic acid and add it to the 2 solution, stir evenly to make a slurry;

[0040] 4. Put the 3 slurry into a high vacuum environment to exhaust for 15 minutes;

[0041] 5. Apply a thin layer of release agent isooctyl alcohol on the inner wall of the mold; measure 3.5ml of catalyst N, N, N', N'-tetramethylethylenediamine and 3.5ml of initiator ammonium persulfate (ensure that there is enough Injection molding time), add in 4 slurry, stir evenly;

[0042] 6. After the grouting is completed, put it in a vacuum drying oven with a constant temperature of 60°C to dry;

[0043] 7. After drying for 30 minutes, remove the mold, trim the blank, and then ...

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Abstract

The invention relates to a gel casting preparation method for a medical multi-hole titanium-cobalt alloy implant. The gel casting preparation method pertains to the technical field of the medical material preparation. Acrylamide monomer, a crosslinking agent N, N'-methylene-bisacrylamide and deionized water are prepared into a premixed solution with a certain concentration; a dispersing agent oleic acid is added to the premixed solution to lead titanium-cobalt alloy powders to suspend in the premixed solution so as to prepare a slurry body; the pH value is adjusted to 9.0 to 10.0, then a proper amount of catalyst N, N, N', N'-TMEDA (tetramethylethylenediamine) and an evocating agent ammonium persulfate are added to the slurry body and are evenly stirred, then the slurry body is injected to a mold after being degassed; monomers in the mold undergo polymerization, therefore, a meshy structure is formed to cover the titanium-cobalt powders, then a blank body meshy-shaped by large molecules is formed. A product is obtained after the blank body is dried, batched out and sintered. In addition, the porosity and the mechanical property of the multi-hole titanium-cobalt alloy can be changed through adjusting the solid content, so as to meet the performance requirements of various medical implants. The gel casting preparation method for the multi-hole titanium-cobalt alloy medical implant requires no complicate devices and special degreasing techniques, has simple process, can greatly reduce production costs, and is particularly applicable to the medical implants with the characteristics of various specifications and mass production.

Description

technical field [0001] The invention belongs to the technical field of medical material preparation, and in particular provides a method for preparing a porous medical implant with excellent biocompatibility and complex shape by gel injection molding. Background technique [0002] Titanium-based alloy has good biocompatibility, low density, close to human bone tissue, low elastic modulus, and significantly higher strength than other metals, and good corrosion resistance. Its various characteristics are closer to cortical bone than other metals. , suitable for use as a biomedical implant material. Porous titanium-cobalt alloy has the structural advantages of a porous three-dimensional scaffold. The three-dimensional through pores and the appropriate surface microporous structure provide a scaffold for the growth of surrounding tissues, so that the tissues and implants can be firmly fixed physiologically; Metals have excellent chemical and mechanical properties and biocompati...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/06A61L27/56B22F3/12
Inventor 邵慧萍杨晓亮林涛郭志猛周永宋宇
Owner UNIV OF SCI & TECH BEIJING
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