Blood filtering replacement liquid prescription special for anti congealing

Abstract

The invention relates to a formula of a blood filtration replacement fluid which is special for citrate anticoagulation, a preparation method and a usage thereof. With the components of sodium citrate, sodium chloride, potassium chloride, sodium lactate, citric acid and so on, the replacement fluid is mainly used for blood filtration and blood dialysis filtration of the patients with acute renal failure or high risk bleeding due to multiple organ failure etc., and can solve the problems of easy occurrence of hypernatremia and alkali poisoning in the prior citrate anticoagulation, thus facilitating the clinical usage. The replacement fluid has the advantages of strong applicability, exact efficacy and low toxicity and side effects; the preparation process is simple; the quality is stable, safe and effective; the feasibility is strong; the repeatability is high; and the replacement fluid is applicable to the large-scale production and the promotion of the clinical application, thus being the ideal blood filtration replacement fluid for blood filtration, blood dialysis filtration, continuous renal replacement therapy and so on. The demand of the blood dialysis increases along with the increasing number of the patients with the end-stage renal failure year by year, so the blood filtration replacement fluid can generate more tremendous economic and social benefits.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food and beverage, in particular to a formula for anticoagulant special blood filtration replacement fluid and its preparation method and use, more specifically to a citrate anticoagulant special blood The formulation of filter replacement solution and its preparation method and application. Background technique [0002] 1. Research progress of hemofiltration technology [0003] Hemofiltration is to imitate the filtration function of glomeruli. It uses a filter membrane with a larger pore size to uniformly filter out water and small molecule toxins in uremia from the body by the effect of transmembrane pressure. At the same time, it relies on infusion devices Simultaneously input the balance liquid with the same composition as the extracellular fluid, so as to remove the toxic substances in the blood through membrane filtration, that is, to remove small molecular substances and excess ...

AI Technical Summary

Problems solved by technology

[0059] (4) A large amount of rehydration is required in the anuric state;

[0063] (2) Hemodynamic instability;

[0086] (1) Use with caution in patients with lactate intolerance

[0087] (2) Squeeze the plastic bag hard before use, and check it carefully. If there is leakage or the liquid is not clear, do not use it.

[0089] (4) Uncleanness, damage or repeated use of pipeline instruments and low temperature may easily cause infusion reactions such as chills and fever after using this product

Disadvantages: It is more complicated to use, and the compatibility of the three liquids is more troublesome when used, which increases the chance of contamination and possible compatibility errors

[0109] After literature search, so far, no relevant reports have been found on the formulation, preparation method and use of the new anticoagulant citrate hemofiltration replacement solution.

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