Novel composing prescription sustained-release preparation for treating high blood pressure and preparation method thereof

Abstract

The invention relates to a sustained-release preparation with novel composition for curing high blood pressure and a preparation method thereof. The novel composition consists of a cardiac selective Beta1 blocker metoprolol and an angiotensin II receptor antagonist (sartans). The sustained-release preparation consists of a sustained release section and a fast release section, wherein, the cardiac selective Beta1 blocker metoprolol is the sustained release section and the angiotensin II receptor antagonist (sartans) is the immediate-release section. The cardiac selective Beta1 blocker metoprolol releases 25 percent to 45 percent in the first hour, 40 percent to 75 percent in the fourth hour, and above 75 percent in the eighth hour; while the angiotensin II receptor antagonist (sartans) releases above 75 percent after 45 min. The invention has quick and long-lasting effect, and discloses the vitro release characteristics and preparation method of the sustained-release preparation.

Description

Technical field [0001] The invention relates to a sustained-release preparation of a new prescription for treating hypertension and a preparation method thereof, and belongs to the technical field of medicine. Background technique [0002] Metoprolol is a selective β1 receptor blocker, which can block myocardial β1 receptors, slow down heart rate, inhibit cardiac contractility and atrioventricular conduction, reduce cardiac output and circulating blood flow, and reduce myocardial oxygen consumption ; It can also reduce the secretion of renin and aldosterone, reduce vascular tone, blood volume and blood pressure. It can be used to treat hypertension and angina pectoris, reduce the incidence of myocardial infarction and reduce the mortality rate after myocardial infarction. A study confirmed the efficacy of metoprolol sustained-release tablets in the treatment of hypertension. Methods: 38 patients with hypertension in Han and Han ethnic groups took Metoprolol sustained-release tabl...

AI Technical Summary

Problems solved by technology

[0004] Both metoprolol and angiotensin II receptor antagonists can be used to treat hypertension. They have different action sites and methods to indirectly or directly play a role in lowering blood pressure. Clinically, doctors can choose according to their needs. Appropriate angiotensin II receptor antagonists and metoprolol are used in combination to achieve a synergistic effect, but often due to inaccurate dose control, it will bring discomfort to patients or fail to achieve the ideal antihypertensive effect