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Preparation of material for bone plate, bone peg and bone block

A technology of bone nails and bone plates is applied in the field of preparation of hard tissue repair materials, which can solve problems such as excessive degradation of materials, and achieve the effects of improving mechanical and mechanical properties, easy industrial production, and strong practicability.

Inactive Publication Date: 2008-07-02
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from the initial bending strength, this type of material can basically meet the requirements of clinical use, but in subsequent in vitro and in vivo degradability experiments, it was found that the above materials degrade too quickly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Hydroxyapatite is prepared by precipitation method. After drying the apatite slurry at 100°C, it is ground and sieved, and the chitosan fiber, polylactic acid, and compatibilizer are vacuum-dried at 90°C. The ratio is 40 / 10 / 45 / 5. Add the four materials into a high-speed mixer and mix them evenly, and then add them into a twin-screw extruder for melt blending and extrusion. The set melting temperature zones are: 160°C, 165°C, 165°C, 170°C, 170°C and 165°C; the speed of the main screw is 140 rpm, the speed of the feeding screw is 14 rpm, and the extruded product passes through the water tank After cooling, pelletize with a pelletizer with a rotating speed of 12 rpm to obtain a composite material pellet product. After the product is dried at 100°C, it is made into a desired product with a precision injection machine. According to ASTM D790 and ASTM D732 standards, the flexural strength of the sample bar is 268.7MPa, the flexural modulus is 15.5GPa, and the shear strength ...

Embodiment 2

[0032] After the chitosan long fiber is irradiated with plasma, carboxyl groups are connected, and hydroxyapatite, polylactic acid, and compatibilizer are blended and melted and extruded through a twin-screw extruder. The set melting temperature range is: 150 °C, 160 °C, 160 °C, 165 °C, 165 °C and 160 °C; the main screw speed was 300 rpm, the hydroxyapatite was treated with a silane coupling agent containing double bonds, and then mixed with polylactic acid containing double bonds Macromonomers are copolymerized. The mass fraction of polylactic acid / chitosan fiber / hydroxyapatite / compatibilizer is 90 / 50 / 10 / 1, and then injection molded into a product with a required shape by an injection molding machine. According to ASTM D790 and ASTM D732 standards, the flexural strength of the sample bar is 267.7MPa, the flexural modulus is 15.6GPa, and the shear strength is 170.4MPa.

Embodiment 3

[0034] The chitosan fiber surface is grafted with lactide, nano-scale hydroxyapatite grafted with polylactic acid macromer and polylactic acid are blended and melted and extruded through a twin-screw extruder, and the set melting temperature zones are sequentially : 180°C, 185°C, 185°C, 190°C, 190°C and 185°C; the speed of the main screw is 300 rpm, and then the product is molded into the desired shape by the injection molding machine. The mass fraction of polylactic acid / chitosan fiber / hydroxyapatite compatibilizer is 40 / 5 / 60 / 10, and the flexural strength of the sample measured according to ASTM D790 and ASTM D732 standards is 250.5MPa, and the flexural modulus is 14.6GPa , The shear strength is 165.3MPa.

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Abstract

The invention discloses a preparation method of materials which are used for bone plates, bone nails and bone blocks, including the following steps: biomedical fiber, hydroxyapatite, polylactic acid and compatibilizer are arranged at a twin-screw extruder or a torque rheometer for melt blending; or the polylactic acid and the hydroxyapatite which is grafted by using the polylactic acid macromonomer are dissolved in chloroform, the biomedical fiber is added for even dispersion, and the thin film can be obtained by vacuum drying after the volatilization of the chloroform; or the polylactic acid and the biomedical fiber are woven into mesh structure, then the mixed solution of hydroxyapatite powder which is grafted by using the polylactic acid macromonomer and the polylactic acid is added, and the vacuum drying is carried out after the volatilization of the solvent; finally, the materials which are obtained by the method are done with the pressing forming on a flat sulphuration machine or done with the injection forming by using a precise injection machine. The preparation method of the materials which are used for the bone plates, bone nails and bone blocks of the invention has strong practicality, easy industrial production and can significantly improve the mechanical properties of the bone repair materials.

Description

technical field [0001] The invention relates to a preparation method for a hard tissue repair material, in particular to a preparation method for bone plates, bone nails and bone blocks. technical background [0002] Bone trauma is a common disease in clinical surgery. In my country, there are more than 10 million patients with bone injuries, spinal fusion, and bone cysts caused by various reasons every year, and about 500,000 of them need to use bone repair materials. With the aging of the population structure, the development of transportation and manufacturing, and the increasing environmental pollution, this number is still rising. Lesions and injuries of bone tissue directly affect people's quality of life, so the repair of bone tissue damage has always been a medical research topic that people have paid close attention to. Implantation of artificial materials into the body to repair or replace diseased and damaged bone tissue is the main clinical treatment method. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/20A61L27/18A61L27/12A61L31/06
Inventor 周长忍张秀菊林志丹
Owner JINAN UNIVERSITY
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