Method for abstracting active compound rich in echinacoside and feltwort glycoside

Abstract

The invention provides a system integration technology through cell disruption, slurry extraction, membrane separation and macroporous resin adsorption and chromatography separation and purification, high temperature enzyme deactivation and spray drying and the like, which achieves a technical process that from the time fresh cistanche raw materials are fed until obtaining active matters such as monomeric compounds which are rich in echinacoside and verbascoside and the like in 30 to 80 minutes, and the invention effectively overcomes a technical defect that active components such as benzyl carbinol glycosides compounds are normally seriously degraded and lost, which are caused by an enzymatic reaction which is initiated by an imperfect dry treatment method of cistanche, and the invention obviously improves the medical value of cistanche. In the active maters of cistanche which are obtained ( calculating by dry matter), the productivity of echinacoside monomeric compound reaches to 9.8% to 19.6%, and the yield of verbascoside monomeric compound reaches to 2.0% to 7.5%. The content of echinacoside monomeric compound in active matters of cistanche which are obtained reaches to 15% to 49.6%, and the content of verbascoside monomeric compound reaches to 5% to 26.7%.

Description

technical field [0001] The invention relates to a method for extracting active substances rich in echinacoside and verbascoside monomer compounds and the like from Cistanche deserticola with high yield. Background technique [0002] Herba Cistanches (Herba Cistanches) is a perennial parasitic herb of the genus Cistanche (Cistanche Hoffmg.et Link) in the family Cistanche. Cistanche deserticola was first recorded in "Shen Nong's Materia Medica" and listed as a top grade. It has the functions of nourishing kidney yang, nourishing essence and blood, moistening intestines and laxative; it is used to treat impotence in men, infertility in women, soreness of waist and knees, weakness of muscles and bones, dryness of the intestines and constipation. Since it was discovered that the phenylethanoid glycosides rich in Cistanche deserticola have significant curative effects on the treatment of vascular dementia, especially the potential effects of invigorating the kidney and yang and en...

AI Technical Summary

Problems solved by technology

[0006] The invention proposes a production method for extracting active substances rich in echinacoside and verbascoside monomer compounds from fresh Cistanche deserticola fleshy stems with high yield through system integration technology, through cell crushing process, serous extraction process, membrane separation and The implementation of system integration technologies such as macroporous resin adsorption and chromatographic separation and purification process, high-temperature enzyme inactivation process, spray drying process, etc., the process flow is short, water is used as a solvent and the amount is very small, which meets the environmental protection requirements of energy saving and emission reduction. Within ~80 minutes, the raw materials of Cistanche deserticola are fed into high yields to obtain active substances such as echinacoside and verbascoside monomeric compounds, which can effectively restrain, block and overcome the enzymes caused by the bad drying treatment methods of Cistanche deserticola. The technical defect of phenylethanol glycosides and other active ingredients caused by the catalytic reaction is severely degraded and lost, which significantly improves the medicinal value of Cistanche deserticola