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Lousewort lignans compounds, preparation method and application thereof

A technology of lignans and Artemisia punctatus, which is applied in the preparation of sugar derivatives, chemical instruments and methods, cosmetic preparations, etc., can solve the problems of lack of antioxidant activity and anti-sports fatigue activity of Artemisia punctatus extracts, and achieve a strong anti-aging effect in the body. Effects of exercise fatigue activity and strong antioxidant activity

Inactive Publication Date: 2008-04-30
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the antioxidant activity and anti-exercise fatigue activity of the extract of Artemisia annua in the prior art

Method used

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  • Lousewort lignans compounds, preparation method and application thereof
  • Lousewort lignans compounds, preparation method and application thereof
  • Lousewort lignans compounds, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Sample pulverization: 11 kg of dried Artemisia densispica (Pedicular is densispica Franch) was pulverized to 40-80 mesh with a plant pulverizer;

[0025] (2) Extraction: Using 95% ethanol which is 3 times the weight of the pulverized product of Artemisia annua as a solvent, the pulverized sample was thermally extracted 3 times at a constant temperature of 50°C, the first time was 4 hours, the second time and the third time were equal for 3 hours, filtered through gauze, and combined the filtrate to obtain the extract;

[0026] (3) Degreasing: the 10% extract (1.1kg) obtained by concentrating the extract under reduced pressure is dissolved in 5L of water, and the aqueous phase is treated with 3×5L petroleum ether, and after layering, the petroleum ether part is separated and removed , the remainder is the water phase part after degreasing;

[0027] (4) Preparation of the n-butanol extract of Artemisia annua

[0028] The degreased aqueous phase was extracted with 3×...

Embodiment 2

[0053] (1) Grinding dried Artemisia dendrobii roots, stems, leaves and fruits, and passing through a 40-mesh sieve;

[0054] (2) Using an ethanol solvent 3 times the weight of the pulverized Artemisia annua, extract under reflux conditions, the extraction temperature is 70-80°C, and the extraction time is 6 hours;

[0055] (3) With the method of vacuum concentration, the solvent extract is concentrated to dryness, and 10% of the sample weight extract obtained by concentrating the extract under reduced pressure is dissolved in water, first degreased with sherwood oil, and then according to the method of Example 1 Extract with ethyl acetate and n-butanol, recover to dryness, and obtain ethyl acetate and n-butanol;

[0056] (4) Weigh 50g of ethyl acetate extract and 50g of n-butanol extract of Artemisia dendrobii, with 10g flow enhancer-micronized silica gel, 20g filler-medicinal lactose, 10g solubilizer-polyvinyl alcohol and 2ml dispersant-spit Mix well at a temperature of 80°C...

Embodiment 3

[0060] The ethyl acetate extract and n-butanol extract obtained according to Example 2 account for 5-50% of the beverage, and other additives and liquid components are mixed to make a health drink.

[0061] When the health drink is in the form of solid packaging, it includes the following weight proportions: 10-50% of the cyclodextrin adsorbate of the ethyl acetate extract and the n-butanol extract, and the rest of other additives are mixed.

[0062] When the health drink is in the form of liquid packaging, the liquid components include: one or more of water, milk, and fruit juice.

[0063] The health drink may include 1-30% flavoring agent: one or more of tea powder, cocoa powder, coffee powder, milk powder, coconut powder, peanut powder, walnut powder, almond powder, sesame, and fruit powder.

[0064] The health drink may also include 0.1-10% sweetener: one or more of sucrose, glucose, maltotetraose, xylitol, sorbitol and aspartame.

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Abstract

The invention relates to a pedicularis nbutanol extract product and pedicularis ethyl acetate extract product extracted from compactear pedicularis plants, or pedicularis lignan methyl Densispicoside A compound (1) obtained and separated from pedicularis nbutanol and stereoisomeride (+)-isolarisiresinol 3a-O-Beta-D-glucopyranoside compound (2). In the free radical eliminating activity research animal experiment, the pedicularis lignan compound provided by the invention shows that the pedicularis lignan methyl Densispicoside A, (+)-isolarisiresinol 3a-O-Beta -D-glucopyranoside, and the compactear pedicularis ethyl acetate and nbutanol extract adopting the compounds as activities also have strong oxidation resisting activity and sports fatigue resisting activity in vivo, and have a wide foreground by being utilized as active constituent in the development of new natural oxidation preventive and sports fatigue resisting medicine.

Description

technical field [0001] The invention relates to a genus lignan compound, a preparation method and an application, and belongs to the technical field of natural plant extraction. Background technique [0002] In recent years, the role of free radical scavengers and antioxidants in food oxidative deterioration has attracted more and more attention. Antioxidants are mainly divided into two categories, one is natural substances, such as vitamin E, vitamin C, vitamin A, flavonoids, etc., which are characterized by low toxicity, low activity, and instability. The other is synthetic antioxidants, such as butylatedhydroxyanisole (BHA for short), butyiated hydroxytolune (BHT for short), etc., which are highly active and stable, and are currently widely used in food . However, due to its potential toxicity and carcinogenicity, it is increasingly rejected by people, so it has become an inevitable trend to search for low-toxicity and high-efficiency natural antioxidants. [0003] Art...

Claims

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Application Information

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IPC IPC(8): C07H15/18C07H1/08A61K31/7028A61P39/06A61K36/80A61K8/60A61Q1/00A61K125/00A61K127/00A61K131/00A61K135/00
Inventor 罗都强褚洪标唐宏亮
Owner HEBEI UNIVERSITY
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