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'Fengliaochangweikang' dispersible tablet and preparation method thereof

A technology of Kang Dispersible Tablets and Feng Liao, which is applied in the field of traditional Chinese medicine dispersible tablets and its preparation, can solve the problems of slow onset of action and low bioavailability, and achieve the effects of good dispersion state, high bioavailability, and convenient storage and transportation

Inactive Publication Date: 2008-04-30
陈益智
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the shortcomings of traditional dosage forms such as slow onset of action and low bioavailability, improve curative effect, reduce side effects, combine the advantages of tablets and liquid preparations, improve product quality, and ensure product curative effect. Based on the selection principle of "small and five conveniences", Fengliao Changweikang Dispersible Tablets and its preparation method are invented and can be rapidly disintegrated in contact with water to form a uniform suspension.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 1000 dosage

[0045] Beef ear maple 4000g

[0046] Spicy Polygonum 2000g

[0047] Microcrystalline Cellulose (MCC) 240g

[0048] Crospovidone (PVPP) 50g

[0049] Sodium Carboxymethyl Starch (CMS-Na) 60g

[0050] Micronized silica gel 6g

[0051] Magnesium Stearate 3g

[0052] Aspartame 3g

[0053] 95% ethanol appropriate amount

[0054] Its preparation process is:

[0055]Take the prescribed amount of maple syringa and Polygonum japonica, add 3000ml of purified water and decoct for 1.5 hours, take the filtrate for later use, add 3000ml of purified water to the residue and decoct for 1 hour, take the filtrate and combine the first decoction liquid, and concentrate under reduced pressure at 60°C to a thick paste shape, dried below 80°C, crushed, passed through a 100-mesh sieve, added cross-linked polyvinylpyrrolidone, microcrystalline cellulose, sodium carboxymethyl starch and aspartame, mixed evenly, 95% ethanol as a wetting agent, granulated, and dr...

Embodiment 2

[0056] Embodiment 2 1000 dosage

[0057] Beef ear maple 4000g

[0058] Spicy Polygonum 2000g

[0059] Microcrystalline Cellulose (MCC) 230g

[0060] Low-substituted hydroxypropyl cellulose 60g

[0061] Sodium Carboxymethyl Starch (CMS-Na) 50g

[0062] Micronized silica gel 6g

[0063] Magnesium Stearate 3g

[0064] Aspartame 3g

[0065] 95% ethanol appropriate amount

[0066] Its preparation process is:

[0067] Take the prescribed amount of maple syringa and Polygonum japonica, add 3000ml of purified water and decoct for 1.5 hours, take the filtrate for later use, add 3000ml of purified water to the residue and decoct for 1 hour, take the filtrate and combine the first decoction liquid, and concentrate under reduced pressure at 60°C to a thick paste shape, dried below 80°C, crushed, passed through a 100-mesh sieve, added low-substituted hydroxypropyl cellulose, microcrystalline cellulose, sodium carboxymethyl starch and aspartame, mixed evenly, 95% ethanol as a wettin...

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PUM

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Abstract

The invention discloses a maple knotweed intestine wei kang dispersible tablet and process for preparation, containing maple knotweed extract and medicinal findings. The proportioning is that maple knotweed extract is 100 parts, the usage of medicinal finding disintegrating agent is 2 to 50 parts, and the usage of medicinal finding filling agent is 5-100 parts, wherein the disintegrating agent is selected from at least one of microcrystal cellulose, cross linked polyvidon, sodium carboxymethylstarch, and low-substituted hydroxypropyl cellulose and cross linked carboxymethyl cellulose sodium. The filling agent is selected from at least one of compressibility starch, starch gum, milk sugar lactose, microcrystal cellulose, and manna sugar. The knotweed intestine wei kang dispersible tablet has the advantages of excellent dispersed state, short disintegration time, quick medicine dissolving, high biology availability, convenient intake, simple medicament arts, low producing cost, and convenient storage and transportation, and does not need vacuum refrigeration, dehumidification, and special package.

Description

technical field [0001] The invention relates to a traditional Chinese medicine dispersible tablet and a preparation method thereof. Background technique [0002] The main ingredients of Fengliao Changweikang are two Chinese herbal medicines: Niu Erfeng and Spicy Liao. Niu Erfeng and La Liao are common folk medicines for treating acute gastritis, enteritis, and dysentery. . As a unique Chinese patent medicine, it requires a reasonable compatibility firstly. The nature and flavor of Auranthus japonica is cold and bitter, while the spicy Liao is warm and pungent. The two are compatible, and the combination of cold and temperature is used to reconcile yin and yang; The intestines are harmonized, and the ascending and descending returns to normal. Thereby effectively eliminating clinical symptoms and restoring the physiological functions of the gastrointestinal tract. Existing tablets, granules, capsules, mixtures, and oral ordinary tablets affect the full absorption of drugs...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/20A61P1/04A61P1/12A61P31/04
Inventor 陈益智
Owner 陈益智
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