Stable antibiotic powder injection
A technology for powder injection and antibiotics, applied in the field of medicine, can solve the problem of high adverse reactions, and achieve the effects of long shelf life, less impurities and high stability
Inactive Publication Date: 2007-10-03
GUANGDONG QIFANG MEDICINES CO LTD
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Problems solved by technology
The high content of impurities is likely to cause high adverse reactions in clinical use. At present, patients with mezlocillin sodium for injection have experienced dizziness, tinnitus, allergic reactions, anaphylactic shock, external genital edema and other adverse reactions, especially allergic reactions. Reactions and anaphylactic shock are basically caused by impurities [see the literature "Pharmaceutical Herald" 2001(5), 330]
Method used
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Effect test
Embodiment 1
[0014] Mix 1 g of sterile mezlocillin with 0.3 g of sterile sodium carbonate, and operate according to the routine powder injection production process.
Embodiment 2
[0016] Mix 1 g of sterile mezlocillin with 0.15 g of sterile sodium carbonate, and operate according to the routine powder injection production process.
Embodiment 3
[0018] Mix 1 gram of sterile mezlocillin with 1 gram of sterile arginine, and operate according to the conventional powder injection production process.
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Abstract
Description
technical field [0001] The invention belongs to the technical field of medicine and relates to a stable antibiotic powder injection. Background technique [0002] Mezlocillin (Mezlocillin) belongs to the benzimidazole penicillin, the chemical name is 2S, 5R, 6R)-3,3-dimethyl-6{(R)-2{(3-(methylsulfonyl)-2-oxo Generation-1-imidazolidinecarbonamide}-2-phenylacetamide}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, the structural formula is as follows: [0003] [0004] As the third-generation semi-synthetic penicillin, mezlocillin has a broad antibacterial spectrum. It has antibacterial effects on most Gram-negative bacteria (including Pseudomonas aeruginosa), Gram-positive bacteria and various anaerobic bacteria. Lactamase has a certain stability. Its clinical curative effect is positive, and it is mainly used to treat infection of kidney, urethra, respiratory tract, biliary tract, genitals, soft tissue, abdomen and other parts or organs, as well as sepsis, wi...
Claims
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/431A61K9/14
Inventor 刘军杨春玮孔庆文
Owner GUANGDONG QIFANG MEDICINES CO LTD
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