Synthesis of iodized plant ethyl oleate for injection

Abstract

The present invention is process of synthesizing iodized vegetable oil ethyl ester. Vegetable oil ethyl ester is first produced through the ester exchange reaction of vegetable oil and anhydrous ethanol under the action of alkali catalyst, and then addition reacted with hydrogen iodide gas to produce iodized vegetable oil ethyl ester, with the hydrogen iodide gas being produced through reaction of iodine, red phosphorus and water. The present invention has facile cheap materials, and the product has high stability, low viscosity, light color and other features.

Description

technical field [0001] The invention relates to a method for synthesizing iodized vegetable oil ethyl ester for injection. Background technique [0002] Contrast medium, also known as contrast medium, is one of the most commonly used diagnostic reagents in interventional radiology operations, mainly used for the display of blood vessels and body cavities. There are various types of contrast agents, and most of the contrast agents currently used in X-ray diagnostics are iodine-containing preparations, that is, the main component is iodine. The characteristic of iodine is that it is opaque to X-rays. Therefore, when taking X-ray films, the distribution of iodine in the body can be used to generate contrast; or to make blood vessels and soft tissues that are usually invisible on X-ray films clear, so as to assist doctors to make reliable decisions. diagnosis. Iodized vegetable oil ethyl ester is clinically called iodized oil ethyl ester, which is mainly used to diagnose liver...

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Problems solved by technology

Chinese Pharmacopoeia (edition 1990) has introduced the production method of iodized oil, but this iodized oil is not transesterified, and viscosity is big, and it is inconvenient to use clinically, and the patient feels pain when injecting, so this iodized oil is mainly used in tonic. iodine, for goiter

Currently clinically used iodized vegetable oil ethyl ester mainly depends on imports, and the price is relatively expensive. Therefore, it is of great significance to develop a production process of iodized vegetable oil ethyl ester with low viscosity and convenient injection.

[0003] Regarding the transesterification reaction process, there are a large number of domestic and foreign literatures reporting the transesterification reaction of vegetable oil and alcohol. At present, the methods of transesterification reaction of vegetable oil mainly contain the following: one is that the transesterification reaction of vegetable oil and alcohol occurs under the catalysis of strong base , the conversion rate of the transesterification reaction of vegetable oil catalyzed by alkali is high, and it is particularly effective for reducing the viscosity of vegetable oil [Lv Liang, New Advances in Rapeseed Oil Transesterification, China Oils and Fats, 2000, 25 (4): 20-21]; the second is vegetable oil and Alcohol undergoes transesterification reaction under acid catalysis, but this method is not as thorough as transesterification under strong base catalysis [Yao Yaguang, Ji Wei, Fu Taijun, Zhang Chuanlong, Zhou Qinghui, Esterification of waste oil and alcohol in catering industry based on acid catalysis Experimental research, Journal of China Agricultural University 2006, 11(3): 113-116]; the third is the transesterification reaction of vegetable oil and alcohol under high temperature and high pressure [Liu Qidong, Wang Cunwen, Wang Weiguo, Wu Yuanxin, Zhang Junfeng, Chi Ruan, Li Shirong , Ding Yigang, Chemical and Biological Engineering, Preliminary Research on Preparation of Biodiesel under Supercritical Conditions, 2006, 23(4): 26-28], but this method requires high temperature and high pressure, and is not suitable for relatively poor thermal stability the substance

The fourth is that vegetable oil and alcohol undergo transesterification under the catalysis of lipase, but the source of lipase is limited, the price is expensive, and methanol, ethanol and by-product glycerin have certain toxicity to the enzyme, which is easy to inactivate the enzyme. These problems are biological The main obstacle to the industrial production of vegetable oil ethyl ester by enzymatic method [Yang Jiguo, Lin Weitie, Wu Junlin, Research Progress of Biodiesel Synthesis by Mold Method, Chemical Environmental Protection, 2004, 24(2): 116-120]

However, trialkylchlorosilanes are used in this method, and trialkylchlorosilanes are easily hydrolyzed to generate high-boiling compounds, which are difficult to remove from the reaction mixture, so this method is not suitable for industrial production

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