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DiAo Xinxuekang soft capsule and preparation process and use thereof

A heart-blood and health-soft technology, applied in capsule delivery, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the problems that have not been reported before, difficult to satisfy patients, single hard capsule dosage form, etc., to improve bioavailability, drug efficacy, etc. Fast-acting, easy-to-swallow effect

Active Publication Date: 2007-08-15
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage form of hard capsules is relatively single, and it is difficult to meet the needs of different patients. As a drug for treating cardiovascular diseases, it requires rapid onset and convenient administration.
Soft capsules can overcome the shortcomings of existing dosage forms, and it has not been reported that the steroidal total saponins extracted from Dioscorea yam and Dioscorea punctatus are prepared into soft capsules.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] [Example 1] Preparation of Di'ao Xinxuekang Soft Capsule Matrix

[0025] Total steroid saponins 100g

[0026] Matrix 350g (polyethylene glycol 400 350g)

[0027] Get the steroidal total saponins extracted from the yellow yam or / and the rhizome of Dioscorea chuanlonga (prepared according to the preparation method under the item Diao Xinxuekang on page 441 of Chinese Pharmacopoeia 2000 Edition, and meet various standards) and pass the fine powder of 100 mesh sieves, After mixing with the matrix evenly, heat in a water bath at 60°C-70°C for 15 minutes, stirring continuously until the total steroidal saponins are dissolved, to obtain liquid 1.

[0028] Take the weight proportioning capsule shell material, capsule shell material 250g (gelatin 90g, glycerin 45g, simple syrup 25g, water 90g; this ratio is the actual consumption, because the capsule shell material in the preparation process, the utilization rate is only 40~50% , the ratio is doubled during production), melt t...

Embodiment 2

[0029] [Example 2] Preparation of Di'ao Xinxuekang Soft Capsule Matrix

[0030] Total steroid saponins 100g

[0031] Base 350g (polyethylene glycol 400 332g, glycerin 18g)

[0032] The preparation method is the same as that of Example 1 to obtain medicinal liquid 2 and soft capsule 2.

Embodiment 3

[0033] [Example 3] Preparation of Di'ao Xinxuekang Soft Capsule Matrix

[0034] Total steroid saponins 100g

[0035] Base 350g (polyethylene glycol 400 315g, glycerin 35g)

[0036] The preparation method is the same as that of Example 1 to obtain medicinal liquid 3 and soft capsule 3.

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PUM

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Abstract

The invention discloses DiAo Xinxuekangsoft capsule which is prepared from (by weight part) steroidal saponins 5-20, substrate 15-30, and capsule 15-50. The active ingredient of steroidal saponins is extracted from Yellow yam or / and rhizome of Dioscorea Nipponica. The invention also discloses preparation method of the soft capsule. The invention has the advantages of simple preparation method, good product stability, high bioavailability, rapid action, and easy deglutition. The capsule can be used for preventing and treating centrum cerebrovascular diseases to satisfy different clinical demand.

Description

technical field [0001] The invention relates to a Di'ao Xinxuekang soft capsule and a preparation method and application thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Di'ao Xinxuekang and its capsule preparations are Class II new Chinese medicines approved by the Ministry of Health in 1988. The main active ingredients are total steroidal saponins extracted from Dioscorea genus yellow yam and Dioscorea chuanlong, including eight steroidal saponins such as diosgenin. Each capsule of Xinxuekang contains 100 mg of total steroidal saponins. The medicine has the functions of promoting blood circulation and removing blood stasis, promoting qi and relieving pain, dilating coronary blood vessels, improving myocardial ischemia, and being used for the prevention and treatment of coronary heart disease, angina pectoris and internal obstruction of blood stasis, such as chest pain, dizziness, shortness of breath, palpitations, chest tightne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K36/8945A61K9/48A61K47/34A61K47/42A61P9/10A61K47/10A61K47/26
Inventor 刘瑜及元乔刘忠荣李伯刚
Owner CHENGDU DIAO PHARMA GROUP
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