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Developing polylactic acid microsphere blood vessel suppository

A vascular embolizing agent and polylactic acid technology are applied in the field of developing polylactic acid-based microsphere vascular embolizing agents, which can solve the problems of easy occurrence of false embolization, affecting long-term curative effect, and difficulty in operation, so as to avoid false embolization and achieve good positioning. , the effect of good visibility

Inactive Publication Date: 2007-08-08
李艳芳 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical use, spring steel rings, surgical thread, and gelatin sponge have good clinical effects in embolizing large blood vessels, but the long-term efficacy is affected by the establishment of collateral circulation
Liquid embolic agents such as cyanoacrylates, dehydrated ethanol, iodized oil, and sodium morrhuate are prone to misembolization in clinical operations and difficult to operate

Method used

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  • Developing polylactic acid microsphere blood vessel suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Developed polylactic acid (PLA) microspheres of the present invention

[0016] Angiographic contrast agents purchased in the market, such as ionic contrast agent Urografin, are processed by vacuum freeze-drying, and the remaining substances after freeze-drying are retained as developing materials (2).

[0017] Using polylactic acid as the biodegradable material (1), the development material (2) microspheres can be conveniently manufactured according to the general process of manufacturing drug-containing microspheres using polylactic acid as a drug wrapping material.

[0018] Polylactic acid is used as a coating material for various drugs to manufacture drug-containing microspheres, and there are many general processes. Such as: Yang Fan et al. published "Research on the Preparation Technology of Ciprofloxacin Polylactic Acid Microspheres" in "Journal of China Pharmaceutical University, 2004, 35 (3): 207-210". The preparation process of lactic acid micros...

Embodiment 2

[0022] Embodiment 2: Developing poly(lactic-co-glycolic acid) (PLGA) microspheres of the present invention

[0023] The production method of the product of this embodiment is basically the same as that of Example 1, except that the biodegradable material (1) is selected as a poly(lactic-co-glycolic acid) copolymer, and the developing material (2) can be selected from one of the following substances: ion Type contrast agent diatrizoate meglumine after vacuum freeze-drying; non-ionic contrast agent iohexol (iohexol) or iopromide (iopromide) or iopamidol (iopamidol) after vacuum freeze-drying The remaining substances after treatment; the remaining substances after the non-ionic dimer iotrolan (iotrolan) and other angiographic contrast agents have been processed by vacuum freeze-drying.

[0024] Most of the developing PLA and developing PLGA microspheres of the present invention are prepared by emulsification dispersion method and phase separation coagulation method. In addition,...

Embodiment 3

[0025] Embodiment 3: Developed polylactic acid-polyether copolymer microspheres of the present invention

[0026] The production method of the product of this embodiment is basically the same as that of Example 1, except that the biodegradable material (1) is selected as polylactic acid-polyether copolymer, and the developing material (2) can be selected from one of the following substances: Ionic contrast agent diatrizoate meglumine after vacuum freeze-drying; non-ionic contrast agent iohexol or iopromide or iopamidol after vacuum freeze-drying The remaining substances after processing; the remaining substances after the non-ionic dimer iotrolan (iotrolan) and other angiographic contrast agents have been processed by vacuum freeze-drying. Microspheres or CO 2 Supercritical fluid technology to prepare microspheres.

[0027] In addition, the degradation time of the developing microspheres of the present invention can be controlled by adjusting the molecular weight and chemica...

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Abstract

The invention relates to a developing polylactic acid micro ball vessel suppository, formed by a biological degradable material in polylactic acid and a developing material and baffle the X-ray, wherein, the biological degradable material coats the developing material to form particle structure. The invention has adjustable degrade time; it has better view property in X-ray to support watching plug part; and after plugging, the nuclear magnetic resonance (MRI) can be process; and the invention can suspend in blood, to approach the end blood vessel along with blood, to deposit and plug the vessel; and the diameter of micro ball can be controlled. The invention has low cost.

Description

technical field [0001] The invention relates to a blood vessel embolism material, in particular to a developing polylactic acid microsphere type blood vessel embolism agent. Background technique [0002] In the prior art, there are many kinds of vascular embolization materials for intervention, mainly including polyvinyl alcohol (Polyvinyl Alcohol, PVA) microspheres, sodium alginate microspheres, gelatin sponge, surgical thread, stainless steel coils, platinum microcoils, Detachable balloons, cyanoacrylates, dehydrated ethanol, iodized oil, sodium morrhuate, etc. In clinical use, spring steel coils, surgical thread, and gelatin sponge have good clinical effects in embolizing large blood vessels, but the long-term efficacy is affected by the establishment of collateral circulation. Liquid embolic agents such as cyanoacrylates, dehydrated ethanol, iodized oil, and sodium morrhuate are prone to misembolization during clinical operations and are difficult to operate. Polyvinyl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/18A61L31/06
Inventor 李艳芳周泰立
Owner 李艳芳
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