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Pharmaceutical composition with antiphlogistic, antitussive and apophlegmatic function and its preparing process

A composition and anti-inflammatory drug technology, applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of poor water solubility, incompleteness, affecting bioavailability and drug efficacy, etc. problem, to achieve low price and good curative effect

Inactive Publication Date: 2007-08-08
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, it has been reported that after oral administration of petracenin by dogs and humans, the absorption is fast, but not complete, and the oral absorption is poor, and the original drug appears in the urine 1 hour after oral administration
Analysis of the reasons shows that petracenin is a kind of organic weak acid with weak lipophilicity, poor water solubility, easy to change color when exposed to light and heat, and difficult to penetrate the lipid bilayer after entering the gastrointestinal tract. It is easily hydrolyzed, so the oral absorption effect is very poor, which affects its bioavailability and efficacy
[0012] However, these reports do not involve how to improve the permeability and stability of petracenin in the gastrointestinal tract, and how to use absorption enhancers and stabilizers to improve the permeability and stability of petracenin Content

Method used

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  • Pharmaceutical composition with antiphlogistic, antitussive and apophlegmatic function and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Weigh 6.25g of petracenin, 0.1g of chlorpheniramine maleate, 2g of carbomer, and 3g of borneol, and mix them uniformly to obtain the pharmaceutical composition.

Embodiment 2

[0045] Weigh 6.25g of petracenin, 12.5g of aspirin, 2g of citric acid, and 6g of lecithin, respectively, dissolve and disperse them in water, mix uniformly, and then spray dry to obtain a pharmaceutical composition.

Embodiment 3

[0047] Take by weighing 6.25g of petracenin, 0.15g of loratadine, 2g of malic acid, and F-686g, dissolve in water respectively, mix uniformly, then add the aqueous solution of mannitol to it, then mix well, carry out freeze-drying, get pharmaceutical composition

[0048] The following are experiments to demonstrate the beneficial effects of stabilizers and absorption enhancers.

Description of drawings

[0049] Figure 1 Stability under different pH conditions

[0050] Fig. 2 is the magnified diagram of stability under pH4.0 and carbomer conditions in Fig. 1

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PUM

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Abstract

The invention relates to a drug compound with antiphlogistic, antibechic, and apophlegmatic functions, which is formed by purple bergenia herb element, anti-inflammatory agent, adsorption accelerator, and stabilizer, wherein, the purple bergenia herb element and anti-inflammatory agent are active components at 1: (0.016-8):(0.16-3):(0.028- 1.7) with the masses of adsorption accelerator and stabilizer. The adsorption accelerator is one or the combination of phosphatide, borneol and F-68. The stabilizer is one or the combination of kabomo, citric acid, citric acid, and malic acid. The adsorption accelerator and the stabilizer can improve the stability and penetration in stomach, to improve the adsorption, utilization and treatment. The invention has low cost and simple production.

Description

technical field [0001] The invention relates to pharmaceutical dosage forms of medical technology, in particular to a pharmaceutical composition with anti-inflammatory, antitussive and expectorant properties and a preparation method thereof. Background technique [0002] At present, there are many anti-inflammatory, antitussive, and expectorant drugs on the market, but there are not many drugs involving natural raw materials such as natural rock cabbage. Bergenin (Bergenin), also known as Bergenin, phyllophyllin, and bergamot, is an active ingredient of the saxifrage plant Bergenin and Astilbe, and belongs to the isocoumarin compound. It has good antitussive, expectorant, anti-inflammatory, antipyretic, antiviral, and promotion of diseased tissue recovery effects. It is included as an antitussive and expectorant in the 2005 edition of the Pharmacopoeia of the People's Republic of China, and is used for the treatment of chronic bronchitis. [0003] Chronic bronchitis, referr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61K31/352A61K31/4402A61K31/4184A61K31/445A61K31/4545A61K31/495A61K31/506A61K31/55A61K31/616A61K47/24A61P11/14A61P11/10A61P11/06A61P11/00A61P29/00
Inventor 黄园张志荣秦瑄周丹
Owner SICHUAN UNIV
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