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Pharyngolaryngitis-treating pharmaceutical compositions and its preparing method

A technology of total flavonoids and extracts, which is applied in the field of iris total flavonoids extracts, can solve the problems of unclear active ingredients and multiple indications, and achieve the effect of reducing sore throat, stable quality, and rapid symptom relief

Inactive Publication Date: 2009-01-07
SICHUAN INST OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This open document reports the crude extract of Iris, with many indications and unclear active ingredients

Method used

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  • Pharyngolaryngitis-treating pharmaceutical compositions and its preparing method
  • Pharyngolaryngitis-treating pharmaceutical compositions and its preparing method
  • Pharyngolaryngitis-treating pharmaceutical compositions and its preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1 The preparation of the total flavonoids of the drug extract iris of the present invention

[0026] (1) The crude drug is crushed into a coarse powder and passed through a 20-mesh sieve, placed in an extraction tank, heated and refluxed with 70% ethanol to extract three times, each time for 1.5 hours, and the amount of each solvent is 4 times the amount of the medicinal material (v / w) , Combine the extracts, filter, and recover ethanol under reduced pressure at 60°C to obtain a syrupy substance (brown yellow extract) with a specific gravity of 1.2g / ml (measured at 50°C). Its yield is 49-51% (w / w) of the feed amount. Stir and dissolve the above-mentioned extract with boiling water (w / w) equivalent to 20 times the amount of the raw drug. The dosage is 3:1, w / w), the flow rate is controlled at 5-10 liters per minute per 100kg resin, the effluent is discarded, and the reaction of magnesium hydrochloride powder in the effluent turns slightly red (take 1ml of the...

Embodiment 2

[0029] The preparation of embodiment 2 pharmaceutical capsules of the present invention

[0030] This product is a hard capsule prepared directly from the total flavonoids extract of iris, and each capsule contains total flavonoids from iris and irisin (C 2 h 22 o 11 ), must not be less than 180mg (every capsule of the present invention fills the extract average weight is about 0.35g).

[0031] Raw material: 350g of iris total flavonoids extract, prepared into 1000 pharmaceutical capsules of the present invention

[0032] (1) Grind the dry total flavonoid extract (content > 55%) through a 60-mesh sieve, and fill No. 1 capsules by hand or with a capsule filling machine under the condition that the relative humidity is less than 64%, and control the content of each capsule to about 0.35 g, prepare 1000 grains.

[0033](2) Dry the total flavonoids extract of iris at 60° C. (steam oven), and crush it through a 60-mesh sieve when the water content is less than 4%. Accurately w...

Embodiment 3

[0034] The preparation of embodiment 3 pharmaceutical tablet of the present invention

[0035] The dry total flavonoid extract (content > 55%) is crushed through a 60-mesh sieve, starch is added, granulated, sized and tabletted to obtain the product.

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Abstract

The invention discloses a pharmaceutical composition for treating pharyngitis and laryngitis, which contains Iris tectorum Maxim. extract flavones as the active ingredient, and pharmaceutically acceptable adjuvant or supplementary constituents, wherein the content of the extract flavones is greater than 55% calculated by Tectoridin C22H22O11. The effective constituents being Tectoridin, Tectoridin A, Tectorigenin, and wild Tectorigenin, the four ingredients have synergic action.

Description

technical field [0001] The invention relates to the use of iris total flavonoids extract, which belongs to the field of traditional Chinese medicine. Background technique [0002] According to traditional Chinese medicine, acute pharyngolaryngitis belongs to the external attack of wind-heat evil poison, and throat obstruction (acute pharyngitis) and acute throat dullness (acute laryngitis) caused by evil heat blocking the lungs are common and frequently-occurring diseases that seriously affect health, often accompanied by Produced by a cold. The onset is acute, with sore throat, hoarseness, headache, fever, and cough with yellow sputum as the main symptoms, and further exacerbation may cause edema and congestion of the throat and nasal mucosa. Modern medicine has confirmed that acute pharyngitis is mostly caused by viruses, mainly including influenza virus, parainfluenza virus, adenovirus, Coxsackie virus, respiratory syncytial virus, rhinovirus, etc. Antibiotics are ineffe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K36/88A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P11/04A61P11/14A61P29/00A61P31/12
Inventor 徐学民袁崇均齐尚斌李利民王笳杨红黄卫平陈帅舒光明
Owner SICHUAN INST OF CHINESE MATERIA MEDICA
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