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33results about How to "Facilitate hybridization" patented technology

Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.
Owner:CARDEA BIO INC

Supporting an assisted satellite based positioning

For supporting a satellite based positioning of a mobile arrangement (30,40) with assistance data, a communication network converts parameters of a dedicated orbit model describing a movement of a satellite (50,60), which dedicated orbit model is defined for a particular satellite based positioning system, into parameters of a common orbit model describing a movement of a satellite (50,60). Alternatively or in addition, the network replaces a reference value that is based on a satellite based positioning system time in available parameters of an orbit model by a reference value that is based on a communication system time. After the parameter conversion and / or the reference value replacement, the parameters are provided as a part of assistance data for the satellite based positioning.
Owner:NOKIA TECHNOLOGLES OY

Nucleic acid amplification oligonucleotides and probes to Lyme disease associated Borrelia

The present invention discloses hybridization assay probes, amplification primers, nucleic acid compositions and methods useful for detecting Borrelia nucleic acids. Hybridization assay probes and amplification primers that selectively detect Lyme disease-associated Borrelia and distinguish those Borrelia from Borrelia hermsii are disclosed. Other hybridization probes selectively detect Borrelia hermsii and not Lyme disease-associated Borrelia are also described.
Owner:GEN PROBE INC

Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.
Owner:CARDEA BIO INC

Methods and devices for molecular association and imaging

The present invention is directed to devices and methods for molecular association, particularly to devices and methods for hybridization of nucleic acids utilizing temperature gradients and imaging thereof. In one aspect, a molecular hybridization system generally includes a substrate having a plurality of molecular probes attached thereto, the plurality of probes being generally present in multiple copies arranged in localized formations on the surface of the substrate. The molecular hybridization system further generally includes a chamber that encloses the plurality of molecular probes such that a fluid containing sample may be applied and kept in contact with the substrate having the probes thereon. The molecular hybridization system also includes a temperature affecting system that generally produces at least one desired temperature on the surface of the substrate and in the adjacent fluid within the chamber.
Owner:BIO TEX LTD INC

Supporting an assisted satellite based positioning

For supporting a satellite based positioning of a mobile arrangement (30,40) with assistance data, a communication network converts parameters of a dedicated orbit model describing a movement of a satellite (50,60), which dedicated orbit model is defined for a particular satellite based positioning system, into parameters of a common orbit model describing a movement of a satellite (50,60). Alternatively or in addition, the network replaces a reference value that is based on a satellite based positioning system time in available parameters of an orbit model by a reference value that is based on a communication system time. After the parameter conversion and / or the reference value replacement, the parameters are provided as a part of assistance data for the satellite based positioning. Alternatively or in addition, a set of data is transmitted in one direction between the mobile arrangement and the communication network, which is independent of the employed positioning mode.
Owner:NOKIA TECHNOLOGLES OY

Supporting an assisted satellite based positioning

For supporting a satellite based positioning of a mobile arrangement (30,40) with assistance data, a communication network converts parameters of a dedicated orbit model describing a movement of a satellite (50,60), which dedicated orbit model is defined for a particular satellite based positioning system, into parameters of a common orbit model describing a movement of a satellite (50,60). Alternatively or in addition, the network replaces a reference value that is based on a satellite based positioning system time in available parameters of an orbit model by a reference value that is based on a communication system time. After the parameter conversion and / or the reference value replacement, the parameters are provided as a part of assistance data for the satellite based positioning. Alternatively or in addition, a set of data is transmitted in one direction between the mobile arrangement and the communication network, which is independent of the employed positioning mode.
Owner:NOKIA TECHNOLOGLES OY

Supporting an assisted satellite based positioning

For supporting a satellite based positioning of a mobile arrangement (30,40) with assistance data, a communication network converts parameters of a dedicated orbit model describing a movement of a satellite (50,60), which dedicated orbit model is defined for a particular satellite based positioning system, into parameters of a common orbit model describing a movement of a satellite (50,60). Alternatively or in addition, the network replaces a reference value that is based on a satellite based positioning system time in available parameters of an orbit model by a reference value that is based on a communication system time. After the parameter conversion and / or the reference value replacement, the parameters are provided as a part of assistance data for the satellite based positioning. Alternatively or in addition, a set of data is transmitted in one direction between the mobile arrangement and the communication network, which is independent of the employed positioning mode.
Owner:NOKIA CORP

Methods for RNA fluorescence in situ hybridization

The present invention provides improved methods for in situ hybridization (ISH) comprising: (a) obtaining a tissue sample from a subject; (b) contacting the tissue sample with a fixative under conditions to cause fixation of the tissue sample; (c) contacting nucleic acids in the tissue sample with a detectable probe under conditions suitable to promote hybridization of the detectable probe to a target RNA in the tissue sample; (d) removing non-bound probe from the tissue sample; and (e) detecting the probe bound to the target RNA.
Owner:EXAGEN DIAGNOSTICS

Synthesis of Peptide Nucleic Acids Conjugated with Amino Acids and Their Application

This invention relates to a peptide nucleic acid (PNA) oligomer which is conjugated with one or more linear-type amino acid containing a plurality of alkyleneglycols and to a synthesis method thereof. In addition, this invention related to a linear amino acid spacer in a device for detection for detecting a target gene using the PNA oligomers which is fixed on a surface of a functionalized solid support. The linear amino acid spacer contains a plurality of alkyleneglycols and maintains enough space between the solid support and PNA oligomer in the device in order to prevent the interference of the interaction between the PNA oligomer and a target gene. Furthermore, this invention relates to a PNA array, a PNA chip and a gene diagnosis kit whereof sensitivity and specificity are improved by being manufactured with the PNA conjugated with the amino acid spacer.
Owner:PANAGENE INC

Nanostructured Working Electrode of an Electrochemical Sensor, Method of Manufacturing Thereof and Sensor Containing This Working Electrode

InactiveUS20080169191A1Transfer become impossibleAllows preparationImmobilised enzymesMaterial nanotechnologyOptoelectronicsNanostructure
A nanostructured working electrode of an electrochemical sensor wherein the working electrode is composed of a material in the form of a film and is inserted onto the sensor. The electrode can be prepared from materials the use of which was impossible in the working electrodes known in the art (e.g. metals of defined purity). A method of manufacturing of the nanostructured working electrode and an electrochemical sensor containing the nanostructured electrode is disclosed
Owner:BVT TECH +1

Methods and Compositions for the Detection and Analysis of Nucleic Acids by Signal Amplification

The present invention relates to a novel integrated PCR-free signal amplification polynucleotide detection system which combines a specific receptor, an optical transducer, and an amplification mechanism. This novel detection system is based on different electrostatic interactions and confirmations between a cationic polythiophene (i.e., polymer 1) and single-stranded or double-stranded polynucleotides (such as ss-DNA or ds-DNA), and the efficient energy transfer between the triplex (complexation between the cationic polythiophene and ds-DNA) and neighboring fluorophores attached to ss-DNA or ds-DNA probes. It is to be understood that in the case of ss-DNA, triplex formation occurs via the hybridization of complementary ss-DNA strands, combined with complexation and with the cationic polythiophene. The present detection system allows for the detection of single nucleotide polymorphisms (SNPs) from samples in only a few minutes, without the need for nucleic acid amplification.
Owner:NAT RES COUNCIL OF CANADA

Nucleic acid probes and amplification oligonucleotides for Neisseria species

The present invention discloses hybridization assay probes, amplification primers, nucleic acid compositions and methods useful for detecting Neisseria nucleic acids. Hybridization assay probes and amplification primers that selectively detect Neisseria meningitidis and distinguish those Neisseria meningitidis from Neisseria gonorrohoeae are disclosed. Other hybridization probes selectively detect Neisseria gonorrohoeae and not Neisseria meningitidis are also described.
Owner:GEN PROBE INC
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