The invention provides a port-out method, a port-out system and a port-out device of a mobile number. The method mainly includes that after a home location register (HLR) deletes local user information according to a command of a business operation supporting system (BOSS), a forcible setting command dispatched by the BOSS are received, wherein the forcible setting command carries a specified mobile switching center (MSC) identification, so that after the HLR finishes a basic service re-signed locally aiming at a user, the HLR serves the MSC corresponding to the specified MSC identification carried in the forcible setting command as an end office of the user, the problem that due to the fact that set end office information for porting out the user possibly is not set in the HLR locally, the port-out failure occurs is effectively solved, and the port-out success rate of the mobile number is improved.