The invention is concerned with minimally invasive orthopaedics operation robot operated with 3D mouse, relating to landscape orientation moving groupware, reducer groupware, fluctuation moving groupware, small arm groupware, wrist groupware and 3D mouse. The 3D mouse sets on the small arm's shell of small arm groupware, the machine seat of reducer groupware connects with revolving flange of landscape orientation moving groupware, the fixing base seat of fluctuation moving groupware connects with the joint of reducer groupware through two lock poles, the sliding groove of small arm groupware connects with the C sliding groove of fluctuation moving groupware and slides in the groove, and the flange of wrist groupware connects with the output axis of reducer to small arm groupware. The robot is fit for the demand of clinic and operation with practicability and applicability. It is a orthopaedics operation robot with initiative restriction and passivity safety ensure.