Methods and devices are provided that are effective to remove an obstruction in a
human airway and / or maintain an open
airway. The methods and devices are particularly useful for patients suffering from snoring and / or OSA, and / or preventing upper
airway obstructions in patients undergoing
anesthesia. In one embodiment, the device includes a
mouthpiece that is adapted to form a substantially sealed cavity within a
human mouth, and a hollow elongate member having a first end that is coupled to the
mouthpiece and that is in communication with the substantially sealed cavity, and a second end that is adapted to be coupled to a negative pressure generator. In use, a negative pressure generator can be attached to the hollow elongate member to create a negative pressure in a
human mouth in response to an obstructed
airway, thereby removing the obstruction. In particular, this device is effective to counteract the collapse of a patient's soft tissues of the upper airway to reopen the airway. The
mouthpiece can also be used in combination with a
nasal mask. In another embodiment, the
oral appliance above also comprises a
nasal mask, wherein the
nasal mask provides a means of ventilation support, including but not limited to
total mechanical ventilation, positive-end expiratory pressure, or
continuous positive airway pressure. In use, such a device can provide complete patient ventilation and maintain an open upper airway.