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Composite neural conduit

a neural conduit and composite technology, applied in the field of composite neural conduits, can solve the problems of mechanical defects, inflammatory responses, and much more difficult, and achieve the effects of improving biocompatibility, reducing the risk of infection, and improving the quality of li

Inactive Publication Date: 2019-09-26
WICHITA STATE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a type of neural conduit that is stronger, more flexible, and more compatible with the body than traditional conduits. This makes them better suited for use in brain and spinal cord surgery.

Problems solved by technology

Restoration of function in the peripheral nervous system is possible, but there are a number of factors surrounding the repair of the central nervous system to make it much more challenging.
For example, bovine collagen is a common biomaterial that mimics a microenvironment suitable for neural growth, but there are issues with mechanical defects and inflammatory responses occurring.

Method used

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Examples

Experimental program
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Effect test

example 1

rotocol

Fabrication of Multichannel Collagen-Soybean Neural Conduits

[0041]Soybean protein isolate (SPI) solutions will be prepared by slowly dissolving the SPI with constant stirring in distilled water with the concentration of 3-15% w / v. The pH may be adjusted to 7.2 with 1M sodium hydroxide or 1M HCl. Then glycerol, 50% w / w, (relative to SPI) will be added to the solution with constant stirring, which helps to stabilize the SPI in solution. The solution will be heated at a constant temperature of 55° C. for 30 min and cooled at room temperature. Then the soybean solution will be mixed with type I collagen solution (10 mg / ml, in acetic acid) as different SPI to collagen ratios (weight to weight) to fabricate neural conduits. The neural conduits are fabricated using the type I collagen-SPI composite according to fabrication methods described in U.S. Pat. No. 8,926,886, incorporated by reference in its entirety herein. Briefly, collagen-SPI solution sequentially self-assembles on the ...

example 2

Neural Conduit

1. Fabrication and Mechanical Properties

1.1 Fabrication of Multichannel Collagen-Soybean Neural Conduits.

[0042]Soybean protein isolate (SPI) solutions were prepared by slowly dissolving the SPI (Soy Protein Isolate, MP Biomedicals™) with constant stirring in distilled water with the concentration of 10% w / v. Then glycerol, 50% w / w, (relative to SPI) was added to the solution with constant stirring. The solution was heated at a constant temperature of 55° C. for 30 min and cooled at room temperature. Then the soybean solution was mixed with type I collagen solution (isolated in lab from bovine tendon; 10 mg / ml, in 50 mM acetic acid) as 1:1 protein weight ratio to fabricate neural conduits. Then 4-channel conduits were fabricated. The matrix was crosslinked with 30 m EDC and 20 mM NHS. After washing with NaH2PO4 (0.1 M) and distilled water, the collagen was freeze-dried on the wires. The resulting conduits are shown in FIG. 2.

1.2 Mechanical Property of the Neural Conduit...

example 3

Neural Hydrogel

1. Fabrication and Mechanical Properties

1.1 Fabrication of a Composite Collagen-Soybean Hydrogels.

[0049]SPI solutions are prepared by adding SPI powder in distilled water with the concentration of 1-10% w / v. Then, glycerol is added to the SPI solution under mechanical stirring at a constant temperature of 55° C. for 30 min and cooled at room temperature.

[0050]The SPI solution is mixed with type I collagen solution (in acetic acid) at various weight ratios, respectively, to form an SPI / collagen solution. To form the hydrogel, the pH value of the SPI / collagen solution is adjusted to 7 by adding a NaOH aqueous solution (1M) and phosphate-buffered saline (PBS) solution (10λ). The gelation takes place by incubating the SPI / collagen solution in the 37° C. incubator.

[0051]The mixture of SPI-collagen solution is crosslinked with 4S-StarPEG at various concentrations. The final 4S-StarPEG concentrations in the SPI-collagen will range between 0.05 mM and 8 mM. A collagen hydroge...

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Abstract

A composite nerve conduit comprising an elongated body comprising one or more hollow elongated internal channels for guiding and promoting nerve regeneration. The conduit is a three-dimensional scaffold comprising a crosslinked hybrid / composite matrix of collagen and soy protein isolate having improved mechanical and biocompatibility properties. Methods of using the conduit for promoting nerve regeneration at a site of neural tissue damage by bridging wounded, severed, or damaged nerve sections in a peripheral and / or central nervous system. Methods of fabricating composite neural conduits are also disclosed.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims the priority benefit of U.S. Provisional Patent Application Ser. No. 62 / 648,208, filed Mar. 26, 2018, entitled COMPOSITE NEURAL CONDUIT, incorporated by reference in its entirety herein.BACKGROUNDField of the Invention[0002]The present invention relates to composite neural conduits having improved properties for repair of neural defects and damage.Description of Related Art[0003]In the field of neural regeneration, neural conduits are used to repair neural defects. Conduits act like a bridge and connect two damaged nerve endings together, providing a channel and scaffold to guide and facilitate nerve growth. As the new nerves grow along the conduit, the two ends can reconnect and restore function. Restoration of function in the peripheral nervous system is possible, but there are a number of factors surrounding the repair of the central nervous system to make it much more challenging.[0004]A variety of condu...

Claims

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Application Information

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IPC IPC(8): A61B17/11A61L27/52A61L27/44A61L27/24B29C70/68
CPCA61L27/52A61L27/44A61B2017/00964B29L2031/753A61B2017/00893A61B2017/1132A61B2017/00526B29C70/68A61L2430/32A61L27/24B29K2089/00A61B17/1128A61L27/3637A61L27/48A61L27/54C08L89/06
Inventor YAO, LI
Owner WICHITA STATE UNIVERSITY
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