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System and stent for repairing endovascular defects and methods of use

a technology of endovascular defects and stents, applied in blood vessels, prostheses, drug compositions, etc., can solve the problems of inconvenient use, inconvenient use, and inability to repair endovascular defects, and achieve the effect of less effective treatment of wide neck aneurysms and intracranial or cerebral pain

Inactive Publication Date: 2014-09-18
PURDUE RES FOUND INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a stent that can be used to repair damaged blood vessels. It can also be used to treat aneurysms. The stent has a layer of magnetic material and a layer of underlayer to help the top layers stick to it better.

Problems solved by technology

Intracranial or cerebral aneurysms, which occur in approximately 2% of the population, are frequently life-threatening when rupture occurs.
Although endovascular coiling has been effective in the treatment of narrow neck aneurysms, it is less effective in treating wide neck aneurysms.
The irregular interface between the coil mass and the parent artery increases the risk of thrombosis leading to stroke, especially in wide neck aneurysms.
Further, because filling the aneurysm sac with coils does not address the diseased parent artery segment, there remains a high risk of regional recurrence of an aneurysm.
However, stent-assisted coiling in the treatment of wide neck aneurysms is problematic due to challenges associated with the anatomical reconstruction of a large segmental parent artery defect and impaired durability of the affected vessel.

Method used

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  • System and stent for repairing endovascular defects and methods of use
  • System and stent for repairing endovascular defects and methods of use
  • System and stent for repairing endovascular defects and methods of use

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Embodiment Construction

[0023]The embodiments disclosed below are not intended to be exhaustive or limit the disclosure to the precise forms disclosed in the following detailed description. Rather, the embodiments are chosen and described so that others skilled in the art may utilize their teachings.

[0024]In one embodiment, the present invention provides stents for use in the treatment of intracranial or cerebral aneurysms. A portion of the stent designed for placement proximal to the neck of the aneurysm comprises a bioactive stent coating. The bioactive stent coating includes a magnetic portion for attracting magnetized cells.

[0025]This disclosure includes a minimally invasive protocol for treatment of cerebral aneurysms. Endovascular surgical treatment makes use of a catheter-based stent deployment to the patient. A bioactive stent coating prototype therefore is used that combines magnetic protocol for cell attraction with surface ion-beam driven nanopatterning for cell regulation at the molecular and c...

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Abstract

Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and / or repair damaged vessels.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application No. 61 / 544,104, filed Oct. 6, 2011, which is incorporated by reference in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]This invention was made with government support under Grant No. W81XWH-11-2-0067 awarded by the U.S. Department of Defense. The United States Government has certain rights in this invention.FIELD OF THE INVENTION[0003]The invention relates generally to a system, vascular stents and methods of repairing endovascular defects. More particularly, the present invention relates to a system, vascular stents, and methods for treating injured or defective blood vessels, including aneurysms, such as neurovascular aneurysms. The vascular stent employed in the system and methods of the invention includes a bioactive coating for use in treatment of injured or defective blood vessels, including intracranial or cerebral aneurysms.BACKGR...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/07A61F2/95A61F2/86
CPCA61F2/07A61F2/95A61F2/86A61L31/088A61L31/10A61L31/16A61L2300/102A61L2300/608A61L2300/64A61L2420/06A61L2420/08A61L31/18A61L2400/12A61F2210/009A61P43/00A61P9/00C08L1/00A61L31/082A61L2400/18
Inventor ALLAIN, JEAN PAULREECE, LISAYANG, ZHANGCANARMONDA, ROCCOKEMPAIAH, RAVINDRATIGNO, TEODORO
Owner PURDUE RES FOUND INC
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