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Soft gel delivery system for treating poultry

a delivery system and soft gel technology, applied in the direction of dispersed delivery, drug composition, antibody medical ingredients, etc., can solve the problems of liquid spillage or wetness, uneven exposure of flocks, and inability to ensure uniform vaccination of flocks

Inactive Publication Date: 2011-09-08
VETECH LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The system provides uniform and effective immunization with reduced wetting risks, maintaining therapeutic agent viability and ease of administration, allowing for efficient hydration and immunization of hatchlings.

Problems solved by technology

Uniform exposure of the flocks to the vaccine cannot always be achieved.
However, given the particulate nature of coccidiosis vaccines, it is doubtful that the vaccine may actually make it to the distal end of the water line, resulting in uneven exposure to the flock.
While this method has numerous advantages, such as reduced levels of oocysts necessary to provide immunization, as well as ease of administration, there is still a drawback in that the provision of open watering systems to hatchlings could result in the liquid being spilled or wetting the hatchlings, which could potentially affect the health of the hatchlings, especially in cold weather and during transportation when hatchlings are vaccinated in the hatchery.
This method suffers some drawbacks in that uniform exposure of all of the hatchlings may not be easily achieved because constant stirring is required to keep oocysts suspended just before spraying.
In addition, as the birds are being sprayed with a water-suspended vaccine, then there is a risk that the hatchlings may become too wet, which may affect the health of the birds.

Method used

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  • Soft gel delivery system for treating poultry
  • Soft gel delivery system for treating poultry

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0037]The apparatus described above was configured to deliver 25 ml of gel to each hatchling tray containing about 100 birds. Day-old cockerels were divided into two groups, a treatment group and a positive control group. The positive control group had 11 birds, from which one bird was inoculated with one ml of gel, five birds were inoculated with 0.5 ml of gel which was done via gel spray. The remaining five birds were inoculated with 0.5 ml water containing about 2×105 oocysts per ml. The carrageenan gel at 1.0 percent containing approximately 2.5×105 oocysts per ml of gel was made and mixed with 6.7 percent blue dye. The treatment group of 92 birds was used for gel spraying. Postmortem examination of the digestive tract of 46 of the gel treated birds was carried out at 15, 30, and 60 minutes after spraying. The remaining birds were examined 5 and 6 days after spraying and lesions were scored from 0 to 4 with 0 being normal and 4 being the maximal lesions.

[0038]Positive evidence o...

example 2

[0041]Four hundred and twenty commercial strain male broiler chickens (Ross×Ross) were obtained at day 1 of age. Birds were randomized to one of two treatment groups replicated six times. Half of the birds, designated treatment 1, were allocated to one of six litter floor pens, 35 birds per pen. The other half of the birds, designated treatment 2, were vaccinated with gel vaccine using the apparatus of the present invention. All treatment replicates were group weighed before placement. Conventional corn / soybean starter, and grower / finisher diets were prepared. Treatment 1 diets were formulated to contain Maxiban® as the anticoccidial ingredient whereas treatment 2 diets contained no anticoccidial. Birds were offered feed and water ad lib. All birds were individually weighed on days 21, and 49 of the trial. Starter diet was fed to day 21; grower / finisher diet to day 49. Birds were monitored for morbidity and mortality twice daily

[0042]Table 1 shows body weight, body weight gain, feed...

example 3

[0044]To compare the efficacy of gel spray delivery, gel puck.delivery, and water diluent delivery of turkey coccidiosis vaccine in a challenge study. Measurements of efficacy include weight gains and lesions scores. Immucox for Turkeys, consisting of Eimeria meleagrimitis and E. adenoeides, was used for immunization.

[0045]Birds were vaccinated at day 1 and housed in single-use cardboard boxes for each treatment, and given feed and water ad libitum. The negative and positive controls were treated similarly and not vaccinated. They were placed in a separate isolation room. To minimize bias all birds were randomly assigned to be in one of the five groups; each bird was tagged and weighed before challenge and again 5 days post-challenge. When birds were 8 days old they were split into two boxes for each treatment group (12-14 birds per box).

[0046]Twenty-seven poults were vaccinated at day 1 by the gel spray machine. Approximately 25 mL of the gel spray mixture was pumped onto the poult...

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Abstract

The present invention is directed to a method of treating poultry hatchlings in a hatchling tray. The method comprises of providing a soft gel form capable of being dispensed through a spray nozzle, providing a spray dispensing apparatus, the apparatus being capable of delivering a predetermined volume of the gel as a plurality of small beadlets through a plurality of nozzles, placing the hatchling tray containing the hatchlings beneath the nozzles of the dispensing apparatus, dispensing the predetermined volume of the soft gel containing the therapeutic agent as small beadlets into the hatchling tray and allowing the hatchlings to consume the beadlets. The present invention is also directed to a dispensing apparatus for dispensing a therapeutic agent in a soft gel into a hatchling tray of poultry hatchlings.

Description

[0001]This application is a divisional of U.S. patent application Ser. No. 11 / 793,047, which is a National Phase entry of International Patent Application Serial No. PCT / CA2005 / 000565 filed 14 Apr. 2005, and claims the benefit of priority of Canadian Patent Application No. 2,464,522, filed on 15 Apr. 2004, which are hereby incorporated by reference.FIELD OF THE INVENTION[0002]The present invention relates to a soft gel delivery system for treating poultry in the hatchery. In particular, the present invention relates to a delivery system for use in a hatchery for delivery of a therapeutic agent to poultry hatchlings.BACKGROUND OF THE INVENTION[0003]There are many circumstances where poultry hatchlings must be treated when they first emerge. Such treatment can include administration of therapeutic agents or it may simply involve maintaining the hydration of the hatchlings during holding and transport. There are many therapeutic agents which are used in the raising of poultry: vaccines...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/012A61K35/66A61P31/02A01K39/00A01K45/00A61D7/00
CPCA01K45/00A01K45/007A61D7/00A61D1/025A61K9/0053A61K9/0095A61K9/06A61K47/36A61P31/02A61P33/00Y02A50/30A01K39/01A01K45/002A61K39/002A61K39/012A61K45/06A61K2039/52A61K2039/54A61K2039/542A61K2039/552A61K2039/70
Inventor LEE, ENG-HONG
Owner VETECH LAB
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